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Cancer cachexia: measured and predicted resting energy expenditures for nutritional needs evaluation.
Nutrition. 2008 May; 24(5):443-50.N

Abstract

OBJECTIVE

Cancer cachexia is associated with weight loss, poor nutritional status, and systemic inflammation. Accurate nutritional support for patients is calculated on resting energy expenditure (REE) measurement or prediction. The present study evaluated the agreement between measured and predicted REE (mREE and pREE, respectively) and the influence of acute phase response (APR) on REE.

METHODS

Thirty-six patients with cancer were divided into weight-stable (WS; weight loss <2%) and weight-losing (WL; weight loss >5%) patients. Measured REE was measured by indirect calorimetry and adjusted for fat-free mass (FFM). The Bland-Altman approach was used to assess the agreement between mREE and pREE from the Harris-Benedict equations (HBE). Blood levels of C-reactive protein were assessed.

RESULTS

There was no difference in mREE between groups (WS 1677 +/- 273, WL 1521 +/- 305) even when mREE was adjusted for FFM (WS 1609 +/- 53, WL 1589 +/- 53). In WL patients, FFM-adjusted REE correlated with blood C-reactive protein levels (r = 0.471, P = 0.048). HBEs tend to underestimate REE in both groups.

CONCLUSION

WL and WS patients with cancer had similar REEs but were different in terms of APR. APR could contribute to weight loss through enhancing REE. In a clinical context, HBE was in poor agreement with mREE in both groups.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale, Unité 694, Université d'Angers; Laboratoire de biochimie et biologie moléculaire, Centre Hospitalier Universitaire, Angers, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18359195

Citation

Johnson, Gyasi, et al. "Cancer Cachexia: Measured and Predicted Resting Energy Expenditures for Nutritional Needs Evaluation." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 5, 2008, pp. 443-50.
Johnson G, Sallé A, Lorimier G, et al. Cancer cachexia: measured and predicted resting energy expenditures for nutritional needs evaluation. Nutrition. 2008;24(5):443-50.
Johnson, G., Sallé, A., Lorimier, G., Laccourreye, L., Enon, B., Blin, V., Jousset, Y., Arnaud, J. P., Malthièry, Y., Simard, G., & Ritz, P. (2008). Cancer cachexia: measured and predicted resting energy expenditures for nutritional needs evaluation. Nutrition (Burbank, Los Angeles County, Calif.), 24(5), 443-50. https://doi.org/10.1016/j.nut.2008.01.013
Johnson G, et al. Cancer Cachexia: Measured and Predicted Resting Energy Expenditures for Nutritional Needs Evaluation. Nutrition. 2008;24(5):443-50. PubMed PMID: 18359195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer cachexia: measured and predicted resting energy expenditures for nutritional needs evaluation. AU - Johnson,Gyasi, AU - Sallé,Agnès, AU - Lorimier,Gérard, AU - Laccourreye,Laurent, AU - Enon,Bernard, AU - Blin,Vincent, AU - Jousset,Yann, AU - Arnaud,Jean-Pierre, AU - Malthièry,Yves, AU - Simard,Gilles, AU - Ritz,Patrick, Y1 - 2008/03/24/ PY - 2007/09/13/received PY - 2007/12/06/revised PY - 2008/01/21/accepted PY - 2008/3/25/pubmed PY - 2008/8/12/medline PY - 2008/3/25/entrez SP - 443 EP - 50 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 5 N2 - OBJECTIVE: Cancer cachexia is associated with weight loss, poor nutritional status, and systemic inflammation. Accurate nutritional support for patients is calculated on resting energy expenditure (REE) measurement or prediction. The present study evaluated the agreement between measured and predicted REE (mREE and pREE, respectively) and the influence of acute phase response (APR) on REE. METHODS: Thirty-six patients with cancer were divided into weight-stable (WS; weight loss <2%) and weight-losing (WL; weight loss >5%) patients. Measured REE was measured by indirect calorimetry and adjusted for fat-free mass (FFM). The Bland-Altman approach was used to assess the agreement between mREE and pREE from the Harris-Benedict equations (HBE). Blood levels of C-reactive protein were assessed. RESULTS: There was no difference in mREE between groups (WS 1677 +/- 273, WL 1521 +/- 305) even when mREE was adjusted for FFM (WS 1609 +/- 53, WL 1589 +/- 53). In WL patients, FFM-adjusted REE correlated with blood C-reactive protein levels (r = 0.471, P = 0.048). HBEs tend to underestimate REE in both groups. CONCLUSION: WL and WS patients with cancer had similar REEs but were different in terms of APR. APR could contribute to weight loss through enhancing REE. In a clinical context, HBE was in poor agreement with mREE in both groups. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18359195/Cancer_cachexia:_measured_and_predicted_resting_energy_expenditures_for_nutritional_needs_evaluation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00036-1 DB - PRIME DP - Unbound Medicine ER -