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Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study).
Am J Cardiol. 2008 Apr 01; 101(7):1016-22.AJ

Abstract

Heart failure (HF) is increasing in prevalence in the United States. Little data exists on race and gender differences in HF incidence rates and case fatality. The Atherosclerosis Risk in Communities (ARIC) cohort is a population-based study from 4 United States communities (1987 to 2002). Prevalent HF cases (n = 750) were identified by self-report and were excluded. Incident HF was defined by the International Classification of Diseases codes for HF (428.0 to 428.9, I50) from a hospitalization (n = 1,206) or death certificate (n = 76). There were 1,282 incident HF cases over 198,417 person-years. The age-adjusted incidence rate (per 1,000 person-years) for Caucasian women, 3.4, was significantly less compared with all other groups (Caucasian men, 6.0; African-American women, 8.1; African-American men, 9.1). Age-adjusted HF incidence rates were greater for African-Americans than Caucasians, but adjustment for confounders attenuated the difference. The adjusted African-American-to-Caucasian hazard ratio was 0.86 (95% confidence interval, 0.70 to 1.06) for men, and similarly, 0.93 (95% confidence interval, 0.46 to 1.90) for women during the second half of follow-up. The hazard ratio for women during the first half of follow-up was 1.79 (95% confidence interval, 1.25 to 2.55). Thirty-day, 1-year, and 5-year case fatalities following hospitalization for HF were 10.4%, 22%, and 42.3%, respectively. African-Americans had a greater 5-year case fatality compared with Caucasians (p <0.05). In conclusion, heart failure incidence rates in African-American women were more similar to those of men than of Caucasian women. The greater HF incidence in African-Americans than in Caucasians is largely explained by African-Americans' greater levels of atherosclerotic risk factors.

Authors+Show Affiliations

University of North Carolina at Chapel Hill, NC, USA. lloehr@email.unc.edu <lloehr@email.unc.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18359324

Citation

Loehr, Laura R., et al. "Heart Failure Incidence and Survival (from the Atherosclerosis Risk in Communities Study)." The American Journal of Cardiology, vol. 101, no. 7, 2008, pp. 1016-22.
Loehr LR, Rosamond WD, Chang PP, et al. Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study). Am J Cardiol. 2008;101(7):1016-22.
Loehr, L. R., Rosamond, W. D., Chang, P. P., Folsom, A. R., & Chambless, L. E. (2008). Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study). The American Journal of Cardiology, 101(7), 1016-22. https://doi.org/10.1016/j.amjcard.2007.11.061
Loehr LR, et al. Heart Failure Incidence and Survival (from the Atherosclerosis Risk in Communities Study). Am J Cardiol. 2008 Apr 1;101(7):1016-22. PubMed PMID: 18359324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study). AU - Loehr,Laura R, AU - Rosamond,Wayne D, AU - Chang,Patricia P, AU - Folsom,Aaron R, AU - Chambless,Lloyd E, Y1 - 2008/02/14/ PY - 2007/09/15/received PY - 2007/11/07/revised PY - 2007/11/07/accepted PY - 2008/3/25/pubmed PY - 2008/5/16/medline PY - 2008/3/25/entrez SP - 1016 EP - 22 JF - The American journal of cardiology JO - Am J Cardiol VL - 101 IS - 7 N2 - Heart failure (HF) is increasing in prevalence in the United States. Little data exists on race and gender differences in HF incidence rates and case fatality. The Atherosclerosis Risk in Communities (ARIC) cohort is a population-based study from 4 United States communities (1987 to 2002). Prevalent HF cases (n = 750) were identified by self-report and were excluded. Incident HF was defined by the International Classification of Diseases codes for HF (428.0 to 428.9, I50) from a hospitalization (n = 1,206) or death certificate (n = 76). There were 1,282 incident HF cases over 198,417 person-years. The age-adjusted incidence rate (per 1,000 person-years) for Caucasian women, 3.4, was significantly less compared with all other groups (Caucasian men, 6.0; African-American women, 8.1; African-American men, 9.1). Age-adjusted HF incidence rates were greater for African-Americans than Caucasians, but adjustment for confounders attenuated the difference. The adjusted African-American-to-Caucasian hazard ratio was 0.86 (95% confidence interval, 0.70 to 1.06) for men, and similarly, 0.93 (95% confidence interval, 0.46 to 1.90) for women during the second half of follow-up. The hazard ratio for women during the first half of follow-up was 1.79 (95% confidence interval, 1.25 to 2.55). Thirty-day, 1-year, and 5-year case fatalities following hospitalization for HF were 10.4%, 22%, and 42.3%, respectively. African-Americans had a greater 5-year case fatality compared with Caucasians (p <0.05). In conclusion, heart failure incidence rates in African-American women were more similar to those of men than of Caucasian women. The greater HF incidence in African-Americans than in Caucasians is largely explained by African-Americans' greater levels of atherosclerotic risk factors. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/18359324/Heart_failure_incidence_and_survival__from_the_Atherosclerosis_Risk_in_Communities_study__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(07)02363-6 DB - PRIME DP - Unbound Medicine ER -