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Adult celiac disease with severe or partial villous atrophy: a comparative study.
Gastroenterol Clin Biol. 2008 Mar; 32(3):236-42.GC

Abstract

BACKGROUND AND AIMS

While severe villous atrophy (SVA) is the most typical histological feature in adult celiac disease (ACD), partial villous atrophy (PVA) is now also frequently found. So far, the impact of the severity of villous atrophy on the clinical presentation of ACD has been scarcely investigated. We aimed to compare the clinical, biological and immune features and outcomes in ACD patients presenting with PVA at diagnosis versus patients with SVA.

PATIENTS AND METHODS

Medical files of 48 patients with ACD diagnosed between 1992 and 2003 were retrospectively studied. The diagnosis was based on the presence of intestinal villous atrophy, with increases in intraepithelial lymphocytes and circulating celiac specific antibodies. Villous atrophy was classified as severe (subtotal and total) or partial. Symptoms, biological signs of malabsorption, immune markers, bone mineral density at diagnosis and response to gluten-free diet were recorded.

RESULTS

At diagnosis, ten patients (four M/six F) had PVA and 38 patients (five M/33 F) had SVA, with a median age of 54 and 33 years, respectively (p<0.05). Positivity for specific antibodies, HLA typing and frequency of autoimmune disease at diagnosis were similar in both PVA and SVA patients, as was their response to gluten-free diet. Diarrhea, malabsorption syndrome and osteopenia were independent of the degree of villous atrophy.

CONCLUSION

PVA was observed in 21% of patients with ACD. Except for their older age at diagnosis, patients with PVA presented with similar clinical, biological and immune characteristics and outcomes as did patients with SVA.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, hôpital européen Georges-Pompidou, 75015 Paris, France. georgia.malamut@egp.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18359595

Citation

Malamut, G, et al. "Adult Celiac Disease With Severe or Partial Villous Atrophy: a Comparative Study." Gastroenterologie Clinique Et Biologique, vol. 32, no. 3, 2008, pp. 236-42.
Malamut G, Matysiak-Budnik T, Grosdider E, et al. Adult celiac disease with severe or partial villous atrophy: a comparative study. Gastroenterol Clin Biol. 2008;32(3):236-42.
Malamut, G., Matysiak-Budnik, T., Grosdider, E., Jais, J. P., Morales, E., Damotte, D., Caillat-Zucman, S., Brousse, N., Cerf-Bensussan, N., Jian, R., & Cellier, C. (2008). Adult celiac disease with severe or partial villous atrophy: a comparative study. Gastroenterologie Clinique Et Biologique, 32(3), 236-42. https://doi.org/10.1016/j.gcb.2008.02.011
Malamut G, et al. Adult Celiac Disease With Severe or Partial Villous Atrophy: a Comparative Study. Gastroenterol Clin Biol. 2008;32(3):236-42. PubMed PMID: 18359595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adult celiac disease with severe or partial villous atrophy: a comparative study. AU - Malamut,G, AU - Matysiak-Budnik,T, AU - Grosdider,E, AU - Jais,J-P, AU - Morales,E, AU - Damotte,D, AU - Caillat-Zucman,S, AU - Brousse,N, AU - Cerf-Bensussan,N, AU - Jian,R, AU - Cellier,C, Y1 - 2008/03/24/ PY - 2008/3/25/pubmed PY - 2008/10/10/medline PY - 2008/3/25/entrez SP - 236 EP - 42 JF - Gastroenterologie clinique et biologique JO - Gastroenterol Clin Biol VL - 32 IS - 3 N2 - BACKGROUND AND AIMS: While severe villous atrophy (SVA) is the most typical histological feature in adult celiac disease (ACD), partial villous atrophy (PVA) is now also frequently found. So far, the impact of the severity of villous atrophy on the clinical presentation of ACD has been scarcely investigated. We aimed to compare the clinical, biological and immune features and outcomes in ACD patients presenting with PVA at diagnosis versus patients with SVA. PATIENTS AND METHODS: Medical files of 48 patients with ACD diagnosed between 1992 and 2003 were retrospectively studied. The diagnosis was based on the presence of intestinal villous atrophy, with increases in intraepithelial lymphocytes and circulating celiac specific antibodies. Villous atrophy was classified as severe (subtotal and total) or partial. Symptoms, biological signs of malabsorption, immune markers, bone mineral density at diagnosis and response to gluten-free diet were recorded. RESULTS: At diagnosis, ten patients (four M/six F) had PVA and 38 patients (five M/33 F) had SVA, with a median age of 54 and 33 years, respectively (p<0.05). Positivity for specific antibodies, HLA typing and frequency of autoimmune disease at diagnosis were similar in both PVA and SVA patients, as was their response to gluten-free diet. Diarrhea, malabsorption syndrome and osteopenia were independent of the degree of villous atrophy. CONCLUSION: PVA was observed in 21% of patients with ACD. Except for their older age at diagnosis, patients with PVA presented with similar clinical, biological and immune characteristics and outcomes as did patients with SVA. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/18359595/Adult_celiac_disease_with_severe_or_partial_villous_atrophy:_a_comparative_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0399-8320(08)00146-2 DB - PRIME DP - Unbound Medicine ER -