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Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome.
Hum Reprod. 2008 Jun; 23(6):1431-8.HR

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidaemia and hypertension which are characteristic features of the metabolic syndrome (MetS).

METHODS

A total of 295 premenopausal Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 30.2 +/- 6.4 years) and 98 control subjects without PCOS were evaluated for prevalence of MetS and cardiovascular risk factors, including dyslipidaemia and dysglycaemia.

RESULTS

Using the 2005 modified Adult Treatment Panel III criteria, MetS (presence of three or more risk factors) was found in 24.9% of PCOS women compared to 3.1% of controls. The prevalence of MetS in PCOS women increased from 16.7% at under 30 years of age to 53.3% at over 40 years. MetS was also more prevalent in overweight and obese (41.3%) than normal-weight PCOS women (0.9%). However, multivariate regression analysis showed that women with PCOS had a 5-fold increase in risk of MetS (odds ratio 4.90; 95% confidence interval: 1.35-17.84) compared with women without PCOS even after controlling for age and BMI, suggesting PCOS alone is an independent risk factor for MetS.

CONCLUSIONS

There is high prevalence of MetS in Hong Kong Chinese women with PCOS despite their relatively young age. Recognition of these cardiometabolic risk factors requires a high level of awareness in conjunction with early and regular screening.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Cheung LP
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. lpcheung@cuhk.edu.hk
Ma RC
No affiliation info available
Lam PM
No affiliation info available
Lok IH
No affiliation info available
Haines CJ
No affiliation info available
So WY
No affiliation info available
Tong PC
No affiliation info available
Cockram CS
No affiliation info available
Chow CC
No affiliation info available
Goggins WB
No affiliation info available

MeSH

AdultBlood GlucoseBody Mass IndexCase-Control StudiesCross-Sectional StudiesDyslipidemiasFemaleHong KongHumansMetabolic SyndromeObesityPolycystic Ovary SyndromePremenopausePrevalenceRisk Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18359783

Citation

Cheung, L P., et al. "Cardiovascular Risks and Metabolic Syndrome in Hong Kong Chinese Women With Polycystic Ovary Syndrome." Human Reproduction (Oxford, England), vol. 23, no. 6, 2008, pp. 1431-8.
Cheung LP, Ma RC, Lam PM, et al. Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome. Hum Reprod. 2008;23(6):1431-8.
Cheung, L. P., Ma, R. C., Lam, P. M., Lok, I. H., Haines, C. J., So, W. Y., Tong, P. C., Cockram, C. S., Chow, C. C., & Goggins, W. B. (2008). Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome. Human Reproduction (Oxford, England), 23(6), 1431-8. https://doi.org/10.1093/humrep/den090
Cheung LP, et al. Cardiovascular Risks and Metabolic Syndrome in Hong Kong Chinese Women With Polycystic Ovary Syndrome. Hum Reprod. 2008;23(6):1431-8. PubMed PMID: 18359783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome. AU - Cheung,L P, AU - Ma,R C W, AU - Lam,P M, AU - Lok,I H, AU - Haines,C J, AU - So,W Y, AU - Tong,P C Y, AU - Cockram,C S, AU - Chow,C C, AU - Goggins,W B, Y1 - 2008/03/21/ PY - 2008/3/25/pubmed PY - 2008/7/24/medline PY - 2008/3/25/entrez SP - 1431 EP - 8 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 23 IS - 6 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidaemia and hypertension which are characteristic features of the metabolic syndrome (MetS). METHODS: A total of 295 premenopausal Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 30.2 +/- 6.4 years) and 98 control subjects without PCOS were evaluated for prevalence of MetS and cardiovascular risk factors, including dyslipidaemia and dysglycaemia. RESULTS: Using the 2005 modified Adult Treatment Panel III criteria, MetS (presence of three or more risk factors) was found in 24.9% of PCOS women compared to 3.1% of controls. The prevalence of MetS in PCOS women increased from 16.7% at under 30 years of age to 53.3% at over 40 years. MetS was also more prevalent in overweight and obese (41.3%) than normal-weight PCOS women (0.9%). However, multivariate regression analysis showed that women with PCOS had a 5-fold increase in risk of MetS (odds ratio 4.90; 95% confidence interval: 1.35-17.84) compared with women without PCOS even after controlling for age and BMI, suggesting PCOS alone is an independent risk factor for MetS. CONCLUSIONS: There is high prevalence of MetS in Hong Kong Chinese women with PCOS despite their relatively young age. Recognition of these cardiometabolic risk factors requires a high level of awareness in conjunction with early and regular screening. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/18359783/Cardiovascular_risks_and_metabolic_syndrome_in_Hong_Kong_Chinese_women_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -