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Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children.
Anaesth Intensive Care. 2008 Mar; 36(2):174-9.AI

Abstract

This study compared the effect of single-dose caudal epidural bupivacaine, bupivacaine plus ketamine and bupivacaine plus tramadol for postoperative pain management in children having surgery for inguinal hernia. Following ethics committee approval and informed parental consent, 75 children ASA PS I and II, between three and nine years of age and scheduled for elective unilateral inguinal hernia repair with general anaesthesia were recruited. The patients were randomly divided into three groups to receive 0.5 ml/kg caudal bupivacaine 0.25% (group B), bupivacaine 0.25% plus tramadol 1 mg/kg (group BT) or bupivacaine 0.25% plus ketamine 0.5 mg/kg (group BK). The injections were performed under general anaesthesia. Mean arterial pressure, heart rate, pulse oximetry, respiratory rate and sedation and pain scores were recorded at defined intervals following recovery from anaesthesia. The groups were similar in age, weight and duration of operation (P >0.05). No patient experienced hypotension, bradycardia or respiratory depression. Duration of analgesia was (mean+/-SD) 6.5+/-4.1 h in group B, 9.2+/-3.9 h in group BK, and 8.5+/-3.1 h in group BT (P <0.05). More patients in group B required supplementary analgesics in the first 24 h (P <0.05). Sedation scores were comparable in all groups. Incidence of emesis and pruritus was similar in all the groups. Caudally administered 0.5 ml/kg bupivacaine 0.25% plus ketamine or bupivacaine 0.25% plus tramadol 1 mg/kg provided significantly longer duration of analgesia without an increase in the adverse effects when compared to bupivacaine alone.

Authors+Show Affiliations

Department of Anaesthesiology, Aruna Asaf Ali Government Hospital, Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18361007

Citation

Choudhuri, A Hom, et al. "Comparison of Caudal Epidural Bupivacaine With Bupivacaine Plus Tramadol and Bupivacaine Plus Ketamine for Postoperative Analgesia in Children." Anaesthesia and Intensive Care, vol. 36, no. 2, 2008, pp. 174-9.
Choudhuri AH, Dharmani P, Kumarl N, et al. Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. Anaesth Intensive Care. 2008;36(2):174-9.
Choudhuri, A. H., Dharmani, P., Kumarl, N., & Prakash, A. (2008). Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. Anaesthesia and Intensive Care, 36(2), 174-9.
Choudhuri AH, et al. Comparison of Caudal Epidural Bupivacaine With Bupivacaine Plus Tramadol and Bupivacaine Plus Ketamine for Postoperative Analgesia in Children. Anaesth Intensive Care. 2008;36(2):174-9. PubMed PMID: 18361007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. AU - Choudhuri,A Hom, AU - Dharmani,P, AU - Kumarl,N, AU - Prakash,A, PY - 2008/3/26/pubmed PY - 2008/5/14/medline PY - 2008/3/26/entrez SP - 174 EP - 9 JF - Anaesthesia and intensive care JO - Anaesth Intensive Care VL - 36 IS - 2 N2 - This study compared the effect of single-dose caudal epidural bupivacaine, bupivacaine plus ketamine and bupivacaine plus tramadol for postoperative pain management in children having surgery for inguinal hernia. Following ethics committee approval and informed parental consent, 75 children ASA PS I and II, between three and nine years of age and scheduled for elective unilateral inguinal hernia repair with general anaesthesia were recruited. The patients were randomly divided into three groups to receive 0.5 ml/kg caudal bupivacaine 0.25% (group B), bupivacaine 0.25% plus tramadol 1 mg/kg (group BT) or bupivacaine 0.25% plus ketamine 0.5 mg/kg (group BK). The injections were performed under general anaesthesia. Mean arterial pressure, heart rate, pulse oximetry, respiratory rate and sedation and pain scores were recorded at defined intervals following recovery from anaesthesia. The groups were similar in age, weight and duration of operation (P >0.05). No patient experienced hypotension, bradycardia or respiratory depression. Duration of analgesia was (mean+/-SD) 6.5+/-4.1 h in group B, 9.2+/-3.9 h in group BK, and 8.5+/-3.1 h in group BT (P <0.05). More patients in group B required supplementary analgesics in the first 24 h (P <0.05). Sedation scores were comparable in all groups. Incidence of emesis and pruritus was similar in all the groups. Caudally administered 0.5 ml/kg bupivacaine 0.25% plus ketamine or bupivacaine 0.25% plus tramadol 1 mg/kg provided significantly longer duration of analgesia without an increase in the adverse effects when compared to bupivacaine alone. SN - 0310-057X UR - https://www.unboundmedicine.com/medline/citation/18361007/Comparison_of_caudal_epidural_bupivacaine_with_bupivacaine_plus_tramadol_and_bupivacaine_plus_ketamine_for_postoperative_analgesia_in_children_ L2 - http://journals.sagepub.com/doi/full/10.1177/0310057X0803600206?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -