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Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process.
Eur J Pharm Biopharm. 2008 Aug; 69(3):1004-13.EJ

Abstract

A new oral-controlled release matrix tablet based on shellac polymer was designed and developed, using metronidazole (MZ) as a model drug. The shellac-based matrix tablets were prepared by wet granulation using different amounts of shellac and lactose. The effect of annealing temperature and pH of medium on drug release from matrix tablets was investigated. The increased amount of shellac and increased annealing temperature significantly affected the physical properties (i.e., tablet hardness and tablet disintegration) and MZ release from the matrix tablets. The in-situ polymerization played a major role on the changes in shellac properties during annealing process. Though the shellac did not dissolve in acid medium, the MZ release in 0.1N HCl was faster than in pH 7.3 buffer, resulting from a higher solubility of MZ in acid medium. The modulation of MZ release kinetics from shellac-based matrix tablets could be accomplished by varying the amount of shellac or annealing temperature. The release kinetics was shifted from relaxation-controlled release to diffusion-controlled release when the amount of shellac or the annealing temperature was increased.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Limmatvapirat S
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Limmatvapirat C
No affiliation info available
Puttipipatkhachorn S
No affiliation info available
Nunthanid J
No affiliation info available
Luangtana-anan M
No affiliation info available
Sriamornsak P
No affiliation info available

MeSH

AlgorithmsCalorimetry, Differential ScanningDelayed-Action PreparationsDrug CompoundingHardnessHydrogen-Ion ConcentrationMetronidazolePolymersResins, PlantSolubilitySurface PropertiesTabletsTemperature

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18362064

Citation

Limmatvapirat, Sontaya, et al. "Modulation of Drug Release Kinetics of Shellac-based Matrix Tablets By In-situ Polymerization Through Annealing Process." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 69, no. 3, 2008, pp. 1004-13.
Limmatvapirat S, Limmatvapirat C, Puttipipatkhachorn S, et al. Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process. Eur J Pharm Biopharm. 2008;69(3):1004-13.
Limmatvapirat, S., Limmatvapirat, C., Puttipipatkhachorn, S., Nunthanid, J., Luangtana-anan, M., & Sriamornsak, P. (2008). Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 69(3), 1004-13. https://doi.org/10.1016/j.ejpb.2008.01.027
Limmatvapirat S, et al. Modulation of Drug Release Kinetics of Shellac-based Matrix Tablets By In-situ Polymerization Through Annealing Process. Eur J Pharm Biopharm. 2008;69(3):1004-13. PubMed PMID: 18362064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process. AU - Limmatvapirat,Sontaya, AU - Limmatvapirat,Chutima, AU - Puttipipatkhachorn,Satit, AU - Nunthanid,Jurairat, AU - Luangtana-anan,Manee, AU - Sriamornsak,Pornsak, Y1 - 2008/02/05/ PY - 2007/12/11/received PY - 2008/01/21/revised PY - 2008/01/22/accepted PY - 2008/3/26/pubmed PY - 2008/10/31/medline PY - 2008/3/26/entrez SP - 1004 EP - 13 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 69 IS - 3 N2 - A new oral-controlled release matrix tablet based on shellac polymer was designed and developed, using metronidazole (MZ) as a model drug. The shellac-based matrix tablets were prepared by wet granulation using different amounts of shellac and lactose. The effect of annealing temperature and pH of medium on drug release from matrix tablets was investigated. The increased amount of shellac and increased annealing temperature significantly affected the physical properties (i.e., tablet hardness and tablet disintegration) and MZ release from the matrix tablets. The in-situ polymerization played a major role on the changes in shellac properties during annealing process. Though the shellac did not dissolve in acid medium, the MZ release in 0.1N HCl was faster than in pH 7.3 buffer, resulting from a higher solubility of MZ in acid medium. The modulation of MZ release kinetics from shellac-based matrix tablets could be accomplished by varying the amount of shellac or annealing temperature. The release kinetics was shifted from relaxation-controlled release to diffusion-controlled release when the amount of shellac or the annealing temperature was increased. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/18362064/Modulation_of_drug_release_kinetics_of_shellac_based_matrix_tablets_by_in_situ_polymerization_through_annealing_process_ DB - PRIME DP - Unbound Medicine ER -