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Effectiveness of probiotics in the treatment of irritable bowel syndrome.
Pharmacotherapy 2008; 28(4):496-505P

Abstract

Recently, the use of tegaserod and alosetron -- drugs approved for the treatment of irritable bowel syndrome (IBS) -- has been restricted because of adverse events. This has resulted in a need for additional modalities for the treatment of IBS. Our objective was to determine the effectiveness of probiotics in the global relief of symptoms associated with IBS and in the improvement of flatulence, abdominal pain, transit time, and bacterial counts. Using the MEDLINE database from 1966-October 2007 and manually searching article references for relevant articles and abstracts, we identified 14 blinded, placebo-controlled clinical trials of the effectiveness of probiotics in the treatment of IBS. Of 11 studies in which overall symptom relief was assessed, seven indicated a significant improvement with probiotics versus placebo. Five of eight investigations of abdominal pain and distention revealed a benefit with probiotic use. Four studies demonstrated an improvement in symptomatic flatulence in probiotic treatment groups, whereas one study showed no significant benefit. Four of five studies of the effects of probiotics on colonic transit time revealed a benefit compared with placebo. As probiotics have shown benefit and possess a favorable adverse-effect profile, their use may represent an option for symptom relief in patients with IBS. However, additional data are necessary before probiotics can become a standard of care in the treatment of IBS, a complex and chronic condition.

Authors+Show Affiliations

Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Harper University Hospital, Detroit, MI, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18363533

Citation

Wilhelm, Sheila M., et al. "Effectiveness of Probiotics in the Treatment of Irritable Bowel Syndrome." Pharmacotherapy, vol. 28, no. 4, 2008, pp. 496-505.
Wilhelm SM, Brubaker CM, Varcak EA, et al. Effectiveness of probiotics in the treatment of irritable bowel syndrome. Pharmacotherapy. 2008;28(4):496-505.
Wilhelm, S. M., Brubaker, C. M., Varcak, E. A., & Kale-Pradhan, P. B. (2008). Effectiveness of probiotics in the treatment of irritable bowel syndrome. Pharmacotherapy, 28(4), pp. 496-505. doi:10.1592/phco.28.4.496.
Wilhelm SM, et al. Effectiveness of Probiotics in the Treatment of Irritable Bowel Syndrome. Pharmacotherapy. 2008;28(4):496-505. PubMed PMID: 18363533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of probiotics in the treatment of irritable bowel syndrome. AU - Wilhelm,Sheila M, AU - Brubaker,Christine M, AU - Varcak,Elizabeth A, AU - Kale-Pradhan,Pramodini B, PY - 2008/3/28/pubmed PY - 2008/6/18/medline PY - 2008/3/28/entrez SP - 496 EP - 505 JF - Pharmacotherapy JO - Pharmacotherapy VL - 28 IS - 4 N2 - Recently, the use of tegaserod and alosetron -- drugs approved for the treatment of irritable bowel syndrome (IBS) -- has been restricted because of adverse events. This has resulted in a need for additional modalities for the treatment of IBS. Our objective was to determine the effectiveness of probiotics in the global relief of symptoms associated with IBS and in the improvement of flatulence, abdominal pain, transit time, and bacterial counts. Using the MEDLINE database from 1966-October 2007 and manually searching article references for relevant articles and abstracts, we identified 14 blinded, placebo-controlled clinical trials of the effectiveness of probiotics in the treatment of IBS. Of 11 studies in which overall symptom relief was assessed, seven indicated a significant improvement with probiotics versus placebo. Five of eight investigations of abdominal pain and distention revealed a benefit with probiotic use. Four studies demonstrated an improvement in symptomatic flatulence in probiotic treatment groups, whereas one study showed no significant benefit. Four of five studies of the effects of probiotics on colonic transit time revealed a benefit compared with placebo. As probiotics have shown benefit and possess a favorable adverse-effect profile, their use may represent an option for symptom relief in patients with IBS. However, additional data are necessary before probiotics can become a standard of care in the treatment of IBS, a complex and chronic condition. SN - 0277-0008 UR - https://www.unboundmedicine.com/medline/citation/18363533/Effectiveness_of_probiotics_in_the_treatment_of_irritable_bowel_syndrome_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18363533.ui DB - PRIME DP - Unbound Medicine ER -