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Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum.
Lett Appl Microbiol. 2008 May; 46(5):575-80.LA

Abstract

AIMS

To investigate the effect of Aloe vera whole leaf extract on pure and mixed human gut bacterial cultures by assessing the bacterial growth and changes in the production of short chain fatty acids.

METHODS AND RESULTS

Bacteroides fragilis, Bifidobacterium infantis, and Eubacterium limosum were incubated with Aloe vera extracts [0%, 0.5%, 1%, 1.5% and 2%; (w/v)] for 24 and 48 h. Short chain fatty acids production was measured by gas chromatography/mass spectrometry analyses. A significant linear increase in growth response to Aloe vera supplementation was observed at 24 h for each of the bacterial cultures; however, only B. infantis and a mixed bacterial culture showed a significant positive linear dose response in growth at 48 h. In pure bacteria cultures, a significantly enhanced dose response to Aloe vera supplementation was observed in the production of acetic acid by B. infantis at 24 h and of butyric acid by E. limosum at 24 and 48 h. In the mixed bacterial culture, the production of propionic acid was reduced significantly at 24 and 48 h in a dose-dependent fashion, whereas butyric acid production showed a significant linear increase.

CONCLUSIONS

The results indicated that Aloe vera possessed bacteriogenic activity in vitro and altered the production of acetic, butyric and propionic acids by micro-organisms selected for the study.

SIGNIFICANCE AND IMPACT OF THE STUDY

The results of the study suggest that consumption of a dietary supplement, Aloe vera, may alter the production of short chain fatty acids by human intestinal microflora.

Authors+Show Affiliations

Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18363656

Citation

Pogribna, M, et al. "Effect of Aloe Vera Whole Leaf Extract On Short Chain Fatty Acids Production By Bacteroides Fragilis, Bifidobacterium Infantis and Eubacterium Limosum." Letters in Applied Microbiology, vol. 46, no. 5, 2008, pp. 575-80.
Pogribna M, Freeman JP, Paine D, et al. Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum. Lett Appl Microbiol. 2008;46(5):575-80.
Pogribna, M., Freeman, J. P., Paine, D., & Boudreau, M. D. (2008). Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum. Letters in Applied Microbiology, 46(5), 575-80. https://doi.org/10.1111/j.1472-765X.2008.02346.x
Pogribna M, et al. Effect of Aloe Vera Whole Leaf Extract On Short Chain Fatty Acids Production By Bacteroides Fragilis, Bifidobacterium Infantis and Eubacterium Limosum. Lett Appl Microbiol. 2008;46(5):575-80. PubMed PMID: 18363656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum. AU - Pogribna,M, AU - Freeman,J P, AU - Paine,D, AU - Boudreau,M D, Y1 - 2008/03/18/ PY - 2008/3/28/pubmed PY - 2008/5/23/medline PY - 2008/3/28/entrez SP - 575 EP - 80 JF - Letters in applied microbiology JO - Lett Appl Microbiol VL - 46 IS - 5 N2 - AIMS: To investigate the effect of Aloe vera whole leaf extract on pure and mixed human gut bacterial cultures by assessing the bacterial growth and changes in the production of short chain fatty acids. METHODS AND RESULTS: Bacteroides fragilis, Bifidobacterium infantis, and Eubacterium limosum were incubated with Aloe vera extracts [0%, 0.5%, 1%, 1.5% and 2%; (w/v)] for 24 and 48 h. Short chain fatty acids production was measured by gas chromatography/mass spectrometry analyses. A significant linear increase in growth response to Aloe vera supplementation was observed at 24 h for each of the bacterial cultures; however, only B. infantis and a mixed bacterial culture showed a significant positive linear dose response in growth at 48 h. In pure bacteria cultures, a significantly enhanced dose response to Aloe vera supplementation was observed in the production of acetic acid by B. infantis at 24 h and of butyric acid by E. limosum at 24 and 48 h. In the mixed bacterial culture, the production of propionic acid was reduced significantly at 24 and 48 h in a dose-dependent fashion, whereas butyric acid production showed a significant linear increase. CONCLUSIONS: The results indicated that Aloe vera possessed bacteriogenic activity in vitro and altered the production of acetic, butyric and propionic acids by micro-organisms selected for the study. SIGNIFICANCE AND IMPACT OF THE STUDY: The results of the study suggest that consumption of a dietary supplement, Aloe vera, may alter the production of short chain fatty acids by human intestinal microflora. SN - 1472-765X UR - https://www.unboundmedicine.com/medline/citation/18363656/Effect_of_Aloe_vera_whole_leaf_extract_on_short_chain_fatty_acids_production_by_Bacteroides_fragilis_Bifidobacterium_infantis_and_Eubacterium_limosum_ DB - PRIME DP - Unbound Medicine ER -