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Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS).
Clin Endocrinol (Oxf). 2008 Oct; 69(4):634-41.CE

Abstract

BACKGROUND

Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels and other tissues in diabetic state and in euglycaemic conditions with increased oxidative stress. Insulin resistant (IR) polycystic ovary syndrome (PCOS) women, have elevated serum AGEs, increased receptor (RAGE) expression, and increased deposition with differential localization in the polycystic ovarian tissue (theca and granulosa) compared to normal.

OBJECTIVE

To determine whether the raised AGE levels in noninsulin resistant women with PCOS is a distinct finding compared with those presenting the isolated components of the syndrome and among PCOS subphenotypes. Noninsulin resistant women were selected in order to show that serum AGEs are elevated in PCOS independently of the presence of IR.

DESIGN

Clinical trial.

PATIENTS

One hundred and ninety-three age- and BMI-matched young lean noninsulin resistant women were studied. Among them, 100 women were diagnosed with PCOS according to Rotterdam criteria, and divided to subphenotypes (hyperandrogenaemia with or without PCO morphology and with or without anovulation). Sixty-eight women with the isolated components of the PCOS phenotype were also studied along with 25 healthy women.

MEASUREMENTS

Serum AGE levels, metabolic, hormonal profiles and intravaginal ultrasound were determined in all subjects.

RESULTS

The studied population did not differ in BMI, fasting insulin concentration, waist : hip and glucose : insulin ratios. PCOS women exhibited statistically higher AGEs levels (7.96 +/- 1.87 U/ml, P < 0.001) compared with those with isolated hyperandrogenaemia (5.61 +/- 0.61 U/ml), anovulation (5.53 +/- 1.06 U/ml), US-PCO morphology (5.26 +/- 0.25 U/ml) and controls (5.86 +/- 0.89 U/ml).

CONCLUSIONS

In PCOS, serum AGEs are distinctly elevated compared with women having the isolated characteristics of the syndrome. No difference was observed between PCOS subphenotypes. As chronic inflammation and increased oxidant stress have been incriminated in the pathophysiology of PCOS, the role of AGEs as inflammatory and oxidant mediators, may be linked with the metabolic and reproductive abnormalities of the syndrome.

Authors+Show Affiliations

First Department of Medicine, Endocrine Section, Laiko Hospital, Medical School, University of Athens, Athens, Greece. akandara@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18363886

Citation

Diamanti-Kandarakis, Evanthia, et al. "Increased Serum Advanced Glycation End-products Is a Distinct Finding in Lean Women With Polycystic Ovary Syndrome (PCOS)." Clinical Endocrinology, vol. 69, no. 4, 2008, pp. 634-41.
Diamanti-Kandarakis E, Katsikis I, Piperi C, et al. Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf). 2008;69(4):634-41.
Diamanti-Kandarakis, E., Katsikis, I., Piperi, C., Kandaraki, E., Piouka, A., Papavassiliou, A. G., & Panidis, D. (2008). Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS). Clinical Endocrinology, 69(4), 634-41. https://doi.org/10.1111/j.1365-2265.2008.03247.x
Diamanti-Kandarakis E, et al. Increased Serum Advanced Glycation End-products Is a Distinct Finding in Lean Women With Polycystic Ovary Syndrome (PCOS). Clin Endocrinol (Oxf). 2008;69(4):634-41. PubMed PMID: 18363886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS). AU - Diamanti-Kandarakis,Evanthia, AU - Katsikis,Ilias, AU - Piperi,Christina, AU - Kandaraki,Eleni, AU - Piouka,Athanasia, AU - Papavassiliou,Athanasios G, AU - Panidis,Dimitrios, Y1 - 2008/03/19/ PY - 2008/3/28/pubmed PY - 2009/8/14/medline PY - 2008/3/28/entrez SP - 634 EP - 41 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 69 IS - 4 N2 - BACKGROUND: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels and other tissues in diabetic state and in euglycaemic conditions with increased oxidative stress. Insulin resistant (IR) polycystic ovary syndrome (PCOS) women, have elevated serum AGEs, increased receptor (RAGE) expression, and increased deposition with differential localization in the polycystic ovarian tissue (theca and granulosa) compared to normal. OBJECTIVE: To determine whether the raised AGE levels in noninsulin resistant women with PCOS is a distinct finding compared with those presenting the isolated components of the syndrome and among PCOS subphenotypes. Noninsulin resistant women were selected in order to show that serum AGEs are elevated in PCOS independently of the presence of IR. DESIGN: Clinical trial. PATIENTS: One hundred and ninety-three age- and BMI-matched young lean noninsulin resistant women were studied. Among them, 100 women were diagnosed with PCOS according to Rotterdam criteria, and divided to subphenotypes (hyperandrogenaemia with or without PCO morphology and with or without anovulation). Sixty-eight women with the isolated components of the PCOS phenotype were also studied along with 25 healthy women. MEASUREMENTS: Serum AGE levels, metabolic, hormonal profiles and intravaginal ultrasound were determined in all subjects. RESULTS: The studied population did not differ in BMI, fasting insulin concentration, waist : hip and glucose : insulin ratios. PCOS women exhibited statistically higher AGEs levels (7.96 +/- 1.87 U/ml, P < 0.001) compared with those with isolated hyperandrogenaemia (5.61 +/- 0.61 U/ml), anovulation (5.53 +/- 1.06 U/ml), US-PCO morphology (5.26 +/- 0.25 U/ml) and controls (5.86 +/- 0.89 U/ml). CONCLUSIONS: In PCOS, serum AGEs are distinctly elevated compared with women having the isolated characteristics of the syndrome. No difference was observed between PCOS subphenotypes. As chronic inflammation and increased oxidant stress have been incriminated in the pathophysiology of PCOS, the role of AGEs as inflammatory and oxidant mediators, may be linked with the metabolic and reproductive abnormalities of the syndrome. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/18363886/Increased_serum_advanced_glycation_end_products_is_a_distinct_finding_in_lean_women_with_polycystic_ovary_syndrome__PCOS__ L2 - https://doi.org/10.1111/j.1365-2265.2008.03247.x DB - PRIME DP - Unbound Medicine ER -