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Risk-based screening for latent tuberculosis infection.
South Med J. 2008 Feb; 101(2):142-9.SM

Abstract

BACKGROUND

National guidelines recommend targeted tuberculin testing and treatment of latent tuberculosis infection (LTBI) among high-risk groups but discourage testing low-risk persons.

METHODS

We determined the LTBI prevalence (tuberculin skin test [TST] reaction > or = 10 mm) among adults with and without TB exposure risk factors screened in Tennessee from 1/2/2002 to 4/19/2005. We then quantified LTBI risk among groups at high-risk for TB using multivariate analysis.

RESULTS

Of 53,061 adults tested, the LTBI prevalence was 34% among foreign-born persons, compared with 3.2% among nonforeign-born persons (prevalence odds ratio [POR] 15.7, 95% confidence interval [CI] 14.5-16.8). Among nonforeign-born adults, Asian race (POR 11.7, 95% CI 5.9-23.4), and Hispanic ethnicity (POR 11.7, 95% CI 9.0-15.2) were most strongly associated with LTBI. Only 2.4% of low-risk persons had LTBI.

CONCLUSIONS

Risk-based screening can effectively distinguish persons who will benefit from LTBI testing and treatment. Targeted testing programs should prioritize foreign-born persons. Testing of low-risk persons is unnecessary.

Authors+Show Affiliations

Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Nashville, Tennessee, USA. connie.haley@comcast.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18364613

Citation

Haley, Connie A., et al. "Risk-based Screening for Latent Tuberculosis Infection." Southern Medical Journal, vol. 101, no. 2, 2008, pp. 142-9.
Haley CA, Cain KP, Yu C, et al. Risk-based screening for latent tuberculosis infection. South Med J. 2008;101(2):142-9.
Haley, C. A., Cain, K. P., Yu, C., Garman, K. F., Wells, C. D., & Laserson, K. F. (2008). Risk-based screening for latent tuberculosis infection. Southern Medical Journal, 101(2), 142-9. https://doi.org/10.1097/SMJ.0b013e3181611c9f
Haley CA, et al. Risk-based Screening for Latent Tuberculosis Infection. South Med J. 2008;101(2):142-9. PubMed PMID: 18364613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk-based screening for latent tuberculosis infection. AU - Haley,Connie A, AU - Cain,Kevin P, AU - Yu,Chang, AU - Garman,Katie F, AU - Wells,Charles D, AU - Laserson,Kayla F, PY - 2008/3/28/pubmed PY - 2008/4/1/medline PY - 2008/3/28/entrez SP - 142 EP - 9 JF - Southern medical journal JO - South Med J VL - 101 IS - 2 N2 - BACKGROUND: National guidelines recommend targeted tuberculin testing and treatment of latent tuberculosis infection (LTBI) among high-risk groups but discourage testing low-risk persons. METHODS: We determined the LTBI prevalence (tuberculin skin test [TST] reaction > or = 10 mm) among adults with and without TB exposure risk factors screened in Tennessee from 1/2/2002 to 4/19/2005. We then quantified LTBI risk among groups at high-risk for TB using multivariate analysis. RESULTS: Of 53,061 adults tested, the LTBI prevalence was 34% among foreign-born persons, compared with 3.2% among nonforeign-born persons (prevalence odds ratio [POR] 15.7, 95% confidence interval [CI] 14.5-16.8). Among nonforeign-born adults, Asian race (POR 11.7, 95% CI 5.9-23.4), and Hispanic ethnicity (POR 11.7, 95% CI 9.0-15.2) were most strongly associated with LTBI. Only 2.4% of low-risk persons had LTBI. CONCLUSIONS: Risk-based screening can effectively distinguish persons who will benefit from LTBI testing and treatment. Targeted testing programs should prioritize foreign-born persons. Testing of low-risk persons is unnecessary. SN - 1541-8243 UR - https://www.unboundmedicine.com/medline/citation/18364613/full_citation L2 - http://dx.doi.org/10.1097/SMJ.0b013e3181611c9f DB - PRIME DP - Unbound Medicine ER -