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Treatment options for the relief of chronic idiopathic urticaria symptoms.
South Med J. 2008 Feb; 101(2):186-92.SM

Abstract

Chronic urticaria is a cutaneous condition in which recurrent pruritic wheals (hives) manifest on the body and typically last for longer than 6 weeks. Chronic urticaria, including physically induced urticarias, such as cold, solar exposure or delayed pressure urticaria, is estimated to occur in approximately 25% of urticaria patients. Of these patients, 75% present with idiopathic disease, which is essentially an exclusionary diagnosis when no contributing factors can be determined that cause the cutaneous reaction. Chronic urticaria symptoms can have a profound effect on a patient's quality of life (QoL); therefore, treatment should address both physical symptom relief and improvements in QoL. This review will discuss the benefits and limitations of several treatment options available to relieve urticarial symptoms, including H1- and H2-receptor antagonists, doxepin, antileukotriene therapy and corticosteroids. Other experimental therapies, such as immunomodulatory agents, plasmapheresis treatment, i.v. immunoglobulins, and omalizumab will also be discussed.

Authors+Show Affiliations

Department of Family Medicine, UCLA School of Medicine, Santa Monica, California, USA. MDWelby@aol.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18364622

Citation

Fromer, Leonard. "Treatment Options for the Relief of Chronic Idiopathic Urticaria Symptoms." Southern Medical Journal, vol. 101, no. 2, 2008, pp. 186-92.
Fromer L. Treatment options for the relief of chronic idiopathic urticaria symptoms. South Med J. 2008;101(2):186-92.
Fromer, L. (2008). Treatment options for the relief of chronic idiopathic urticaria symptoms. Southern Medical Journal, 101(2), 186-92. https://doi.org/10.1097/SMJ.0b013e3181611bc8
Fromer L. Treatment Options for the Relief of Chronic Idiopathic Urticaria Symptoms. South Med J. 2008;101(2):186-92. PubMed PMID: 18364622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment options for the relief of chronic idiopathic urticaria symptoms. A1 - Fromer,Leonard, PY - 2008/3/28/pubmed PY - 2008/4/1/medline PY - 2008/3/28/entrez SP - 186 EP - 92 JF - Southern medical journal JO - South Med J VL - 101 IS - 2 N2 - Chronic urticaria is a cutaneous condition in which recurrent pruritic wheals (hives) manifest on the body and typically last for longer than 6 weeks. Chronic urticaria, including physically induced urticarias, such as cold, solar exposure or delayed pressure urticaria, is estimated to occur in approximately 25% of urticaria patients. Of these patients, 75% present with idiopathic disease, which is essentially an exclusionary diagnosis when no contributing factors can be determined that cause the cutaneous reaction. Chronic urticaria symptoms can have a profound effect on a patient's quality of life (QoL); therefore, treatment should address both physical symptom relief and improvements in QoL. This review will discuss the benefits and limitations of several treatment options available to relieve urticarial symptoms, including H1- and H2-receptor antagonists, doxepin, antileukotriene therapy and corticosteroids. Other experimental therapies, such as immunomodulatory agents, plasmapheresis treatment, i.v. immunoglobulins, and omalizumab will also be discussed. SN - 1541-8243 UR - https://www.unboundmedicine.com/medline/citation/18364622/Treatment_options_for_the_relief_of_chronic_idiopathic_urticaria_symptoms_ L2 - http://dx.doi.org/10.1097/SMJ.0b013e3181611bc8 DB - PRIME DP - Unbound Medicine ER -