Tags

Type your tag names separated by a space and hit enter

Increased risk of immune thrombocytopenic purpura among inpatients with coeliac disease.
Scand J Gastroenterol 2008; 43(4):416-22SJ

Abstract

OBJECTIVE

Case reports have indicated a link between coeliac disease (CD) and immune thrombocytopenic purpura (ITP). Two national, register-based studies were carried out to investigate a possible association between CD and ITP and vice versa.

MATERIAL AND METHODS

In a cohort study of 14,347 individuals with inpatient diagnoses of CD and 69,967 reference individuals matched for age, gender, calendar year and county, the Cox regression was used to estimate the risk of subsequent inpatient diagnoses of ITP (of any type or chronic). In a case control design, conditional logistic regression was used to assess the risk of exposure (diagnosis of ITP prior to CD) in 15,382 cases (individuals with diagnoses of CD) and 76,824 matched controls. Diagnoses of CD and ITP were identified through the Swedish National Inpatient Register.

RESULTS

Individuals with CD were at increased risk of both subsequent ITP of any type (hazard ratio (HR)=1.91; 95% CI=1.19-3.11; p=0.008) and subsequent chronic ITP (HR 2.77; 95% CI=1.09-7.04; p=0.033). Risk estimates were similar when reference individuals were restricted to inpatients. There was also a positive association between CD and prior ITP of any type (odds ratio (OR)=2.96; 95% CI=1.60-5.50; p=0.001) or with prior chronic ITP (OR=6.00; 95% CI=1.83-19.66; p=0.003).

CONCLUSIONS

We found a positive association between CD and both ITP of any type and chronic ITP, irrespective of which disease came first, and suggest there should be increased awareness of CD in patients with ITP.

Authors+Show Affiliations

Sachs' Children's Hospital, Stockholm South General Hospital, Sweden. ola.olen@sodersjukhuset.se

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18365906

Citation

Olén, Ola, et al. "Increased Risk of Immune Thrombocytopenic Purpura Among Inpatients With Coeliac Disease." Scandinavian Journal of Gastroenterology, vol. 43, no. 4, 2008, pp. 416-22.
Olén O, Montgomery SM, Elinder G, et al. Increased risk of immune thrombocytopenic purpura among inpatients with coeliac disease. Scand J Gastroenterol. 2008;43(4):416-22.
Olén, O., Montgomery, S. M., Elinder, G., Ekbom, A., & Ludvigsson, J. F. (2008). Increased risk of immune thrombocytopenic purpura among inpatients with coeliac disease. Scandinavian Journal of Gastroenterology, 43(4), pp. 416-22. doi:10.1080/00365520701814028.
Olén O, et al. Increased Risk of Immune Thrombocytopenic Purpura Among Inpatients With Coeliac Disease. Scand J Gastroenterol. 2008;43(4):416-22. PubMed PMID: 18365906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of immune thrombocytopenic purpura among inpatients with coeliac disease. AU - Olén,Ola, AU - Montgomery,Scott M, AU - Elinder,Göran, AU - Ekbom,Anders, AU - Ludvigsson,Jonas F, PY - 2008/3/28/pubmed PY - 2008/5/21/medline PY - 2008/3/28/entrez SP - 416 EP - 22 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 43 IS - 4 N2 - OBJECTIVE: Case reports have indicated a link between coeliac disease (CD) and immune thrombocytopenic purpura (ITP). Two national, register-based studies were carried out to investigate a possible association between CD and ITP and vice versa. MATERIAL AND METHODS: In a cohort study of 14,347 individuals with inpatient diagnoses of CD and 69,967 reference individuals matched for age, gender, calendar year and county, the Cox regression was used to estimate the risk of subsequent inpatient diagnoses of ITP (of any type or chronic). In a case control design, conditional logistic regression was used to assess the risk of exposure (diagnosis of ITP prior to CD) in 15,382 cases (individuals with diagnoses of CD) and 76,824 matched controls. Diagnoses of CD and ITP were identified through the Swedish National Inpatient Register. RESULTS: Individuals with CD were at increased risk of both subsequent ITP of any type (hazard ratio (HR)=1.91; 95% CI=1.19-3.11; p=0.008) and subsequent chronic ITP (HR 2.77; 95% CI=1.09-7.04; p=0.033). Risk estimates were similar when reference individuals were restricted to inpatients. There was also a positive association between CD and prior ITP of any type (odds ratio (OR)=2.96; 95% CI=1.60-5.50; p=0.001) or with prior chronic ITP (OR=6.00; 95% CI=1.83-19.66; p=0.003). CONCLUSIONS: We found a positive association between CD and both ITP of any type and chronic ITP, irrespective of which disease came first, and suggest there should be increased awareness of CD in patients with ITP. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/18365906/Increased_risk_of_immune_thrombocytopenic_purpura_among_inpatients_with_coeliac_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365520701814028 DB - PRIME DP - Unbound Medicine ER -