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New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum.
J Chromatogr Sci 2008; 46(2):93-6JC

Abstract

It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their trans-benzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-beta coupling is correct.

Authors+Show Affiliations

Béres Pharmaceuticals, Budapest, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18366865

Citation

Nyiredy, Sz, et al. "New Insight Into the Biosynthesis of Flavanolignans in the White-flowered Variant of Silybum Marianum." Journal of Chromatographic Science, vol. 46, no. 2, 2008, pp. 93-6.
Nyiredy S, Samu Z, Szücs Z, et al. New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum. J Chromatogr Sci. 2008;46(2):93-6.
Nyiredy, S., Samu, Z., Szücs, Z., Gulácsi, K., Kurtán, T., & Antus, S. (2008). New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum. Journal of Chromatographic Science, 46(2), pp. 93-6.
Nyiredy S, et al. New Insight Into the Biosynthesis of Flavanolignans in the White-flowered Variant of Silybum Marianum. J Chromatogr Sci. 2008;46(2):93-6. PubMed PMID: 18366865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum. AU - Nyiredy,Sz, AU - Samu,Zs, AU - Szücs,Z, AU - Gulácsi,K, AU - Kurtán,T, AU - Antus,S, PY - 2008/3/28/pubmed PY - 2008/12/18/medline PY - 2008/3/28/entrez SP - 93 EP - 6 JF - Journal of chromatographic science JO - J Chromatogr Sci VL - 46 IS - 2 N2 - It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their trans-benzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-beta coupling is correct. SN - 0021-9665 UR - https://www.unboundmedicine.com/medline/citation/18366865/New_insight_into_the_biosynthesis_of_flavanolignans_in_the_white_flowered_variant_of_Silybum_marianum_ L2 - https://academic.oup.com/chromsci/article-lookup/doi/10.1093/chromsci/46.2.93 DB - PRIME DP - Unbound Medicine ER -