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Exploring causes for declining prostate cancer mortality rates in the United States.
Urol Oncol 2008 Nov-Dec; 26(6):627-33UO

Abstract

OBJECTIVES

Prostate cancer mortality rates in the U.S.A. increased in the late 1980s and declined from 1993 until 2003. The purpose of this study is to compare declining prostate cancer mortality rates among states with independent variables that may have an association to explore causes for the decline.

METHODS AND MATERIALS

Annual rates of prostate cancer mortality for men over 50 were obtained from the National Vital Statistic System public use data file for states for individual years from 1993 to 2003. The annual rate of prostate cancer mortality decline for each state was calculated by the Joinpoint Regression Program (Statistical Research and Applications Branch of NCI). Annual rates of prostate cancer decline were cross-correlated to state levels of PSA screening, health insurance coverage, obesity, physical inactivity, diabetes, and high cholesterol for males from 45 to 64.

RESULTS

Declining prostate cancer mortality rates for white males correlated with high cholesterol levels (R = -0.42, P = 0.002) and PSA screening levels (R = -0.28, P = 0.05). Declining prostate cancer mortality rates for black males correlated with health insurance coverage (R = -0.43, P = 0.03).

CONCLUSIONS

Declining prostate cancer mortality rates are weakly associated with increased PSA screening for white males but there was no association for black males, possibly because blacks have less access to medical care. The strong inverse correlation between declining prostate cancer mortality rates and levels of white males with high cholesterol levels was unexpected but may be associated with the widespread use of cholesterol reducing medications (statins), which are hypothesized to reduce prostate cancer risk.

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    Authors+Show Affiliations

    Colli JL
    Department of Urology, University of Alabama, Birmingham, AL 35294, USA; Birmingham VA Medical Center (VMAC), Birmingham, AL 35294, USA. jan.colli@ccc.uab.edu
    Amling CL
    No affiliation info available

    MeSH

    African Continental Ancestry GroupBrachytherapyEuropean Continental Ancestry GroupHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInterleukin-18MaleMiddle AgedProstatic NeoplasmsUnited States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18367111

    Citation

    Colli, Janet L., and Christopher L. Amling. "Exploring Causes for Declining Prostate Cancer Mortality Rates in the United States." Urologic Oncology, vol. 26, no. 6, 2008, pp. 627-33.
    Colli JL, Amling CL. Exploring causes for declining prostate cancer mortality rates in the United States. Urol Oncol. 2008;26(6):627-33.
    Colli, J. L., & Amling, C. L. (2008). Exploring causes for declining prostate cancer mortality rates in the United States. Urologic Oncology, 26(6), pp. 627-33. doi:10.1016/j.urolonc.2007.05.016.
    Colli JL, Amling CL. Exploring Causes for Declining Prostate Cancer Mortality Rates in the United States. Urol Oncol. 2008;26(6):627-33. PubMed PMID: 18367111.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Exploring causes for declining prostate cancer mortality rates in the United States. AU - Colli,Janet L, AU - Amling,Christopher L, Y1 - 2008/01/14/ PY - 2007/04/07/received PY - 2007/05/15/accepted PY - 2008/3/28/pubmed PY - 2009/1/24/medline PY - 2008/3/28/entrez SP - 627 EP - 33 JF - Urologic oncology JO - Urol. Oncol. VL - 26 IS - 6 N2 - OBJECTIVES: Prostate cancer mortality rates in the U.S.A. increased in the late 1980s and declined from 1993 until 2003. The purpose of this study is to compare declining prostate cancer mortality rates among states with independent variables that may have an association to explore causes for the decline. METHODS AND MATERIALS: Annual rates of prostate cancer mortality for men over 50 were obtained from the National Vital Statistic System public use data file for states for individual years from 1993 to 2003. The annual rate of prostate cancer mortality decline for each state was calculated by the Joinpoint Regression Program (Statistical Research and Applications Branch of NCI). Annual rates of prostate cancer decline were cross-correlated to state levels of PSA screening, health insurance coverage, obesity, physical inactivity, diabetes, and high cholesterol for males from 45 to 64. RESULTS: Declining prostate cancer mortality rates for white males correlated with high cholesterol levels (R = -0.42, P = 0.002) and PSA screening levels (R = -0.28, P = 0.05). Declining prostate cancer mortality rates for black males correlated with health insurance coverage (R = -0.43, P = 0.03). CONCLUSIONS: Declining prostate cancer mortality rates are weakly associated with increased PSA screening for white males but there was no association for black males, possibly because blacks have less access to medical care. The strong inverse correlation between declining prostate cancer mortality rates and levels of white males with high cholesterol levels was unexpected but may be associated with the widespread use of cholesterol reducing medications (statins), which are hypothesized to reduce prostate cancer risk. SN - 1078-1439 UR - https://www.unboundmedicine.com/medline/citation/18367111/Exploring_causes_for_declining_prostate_cancer_mortality_rates_in_the_United_States_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-1439(07)00147-0 DB - PRIME DP - Unbound Medicine ER -