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Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study.
Fertil Steril. 2009 Feb; 91(2):365-71.FS

Abstract

OBJECTIVE

To compare pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS) in donor stimulation cycles where final maturation of oocytes was induced with recombinant hCG or GnRH agonist.

DESIGN

Retrospective, cohort study.

SETTING

Private infertility clinic.

PATIENT(S)

A total of 1171 egg donors performing 2077 stimulation cycles.

INTERVENTION(S)

Controlled ovarian hyperstimulation of egg donors with GnRH antagonist protocol triggered with recombinant hCG (rhCG; 250 microg) or GnRH agonist (triptorelin 0.2 mg) based on the physician's decision.

MAIN OUTCOME MEASURE(S)

Proportion of mature and fertilized oocytes per donor cycle; clinical, ongoing pregnancy and implantation rate in recipients; and incidence of moderate/severe OHSS in oocyte donors.

RESULT(S)

The proportion of mature oocytes was comparable, whereas the difference in the fertilization rate reached statistical significance (65% vs. 69%). No significant differences were observed in the implantation rate or clinical and ongoing pregnancy rates per ET. The incidence of moderate/severe OHSS was 1.26% (13/1031; 95% confidence interval [CI], 0.74-2.15) and 0% (0/1046; 95% CI, 0.00-0.37) in the rhCG and GnRH agonist groups, respectively.

CONCLUSION(S)

Recipient outcome was not significantly different when using oocytes from GnRH antagonist-treated donor cycles triggered with hCG or GnRH agonist. However, GnRH agonist triggering was associated with a lower incidence of moderate/severe OHSS in egg donors.

Authors+Show Affiliations

Clínica EUGIN, Barcelona, Spain. dbodri@telefonica.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18367175

Citation

Bodri, Daniel, et al. "Triggering With Human Chorionic Gonadotropin or a Gonadotropin-releasing Hormone Agonist in Gonadotropin-releasing Hormone Antagonist-treated Oocyte Donor Cycles: Findings of a Large Retrospective Cohort Study." Fertility and Sterility, vol. 91, no. 2, 2009, pp. 365-71.
Bodri D, Guillén JJ, Galindo A, et al. Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study. Fertil Steril. 2009;91(2):365-71.
Bodri, D., Guillén, J. J., Galindo, A., Mataró, D., Pujol, A., & Coll, O. (2009). Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study. Fertility and Sterility, 91(2), 365-71. https://doi.org/10.1016/j.fertnstert.2007.11.049
Bodri D, et al. Triggering With Human Chorionic Gonadotropin or a Gonadotropin-releasing Hormone Agonist in Gonadotropin-releasing Hormone Antagonist-treated Oocyte Donor Cycles: Findings of a Large Retrospective Cohort Study. Fertil Steril. 2009;91(2):365-71. PubMed PMID: 18367175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study. AU - Bodri,Daniel, AU - Guillén,Juan José, AU - Galindo,Anna, AU - Mataró,Daniel, AU - Pujol,Aïda, AU - Coll,Oriol, Y1 - 2008/03/25/ PY - 2007/09/27/received PY - 2007/11/16/revised PY - 2007/11/16/accepted PY - 2008/3/28/pubmed PY - 2009/2/21/medline PY - 2008/3/28/entrez SP - 365 EP - 71 JF - Fertility and sterility JO - Fertil Steril VL - 91 IS - 2 N2 - OBJECTIVE: To compare pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS) in donor stimulation cycles where final maturation of oocytes was induced with recombinant hCG or GnRH agonist. DESIGN: Retrospective, cohort study. SETTING: Private infertility clinic. PATIENT(S): A total of 1171 egg donors performing 2077 stimulation cycles. INTERVENTION(S): Controlled ovarian hyperstimulation of egg donors with GnRH antagonist protocol triggered with recombinant hCG (rhCG; 250 microg) or GnRH agonist (triptorelin 0.2 mg) based on the physician's decision. MAIN OUTCOME MEASURE(S): Proportion of mature and fertilized oocytes per donor cycle; clinical, ongoing pregnancy and implantation rate in recipients; and incidence of moderate/severe OHSS in oocyte donors. RESULT(S): The proportion of mature oocytes was comparable, whereas the difference in the fertilization rate reached statistical significance (65% vs. 69%). No significant differences were observed in the implantation rate or clinical and ongoing pregnancy rates per ET. The incidence of moderate/severe OHSS was 1.26% (13/1031; 95% confidence interval [CI], 0.74-2.15) and 0% (0/1046; 95% CI, 0.00-0.37) in the rhCG and GnRH agonist groups, respectively. CONCLUSION(S): Recipient outcome was not significantly different when using oocytes from GnRH antagonist-treated donor cycles triggered with hCG or GnRH agonist. However, GnRH agonist triggering was associated with a lower incidence of moderate/severe OHSS in egg donors. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18367175/Triggering_with_human_chorionic_gonadotropin_or_a_gonadotropin_releasing_hormone_agonist_in_gonadotropin_releasing_hormone_antagonist_treated_oocyte_donor_cycles:_findings_of_a_large_retrospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)04110-6 DB - PRIME DP - Unbound Medicine ER -