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Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir.
J Pharm Biomed Anal. 2008 Jul 15; 47(3):535-40.JP

Abstract

The solid-state properties, dissolution profile and antimicrobial activity of inclusion complexes of cefdinir (CEF) with beta-cyclodextrin (betaCD) and hydroxypropyl beta-cyclodextrin (HPbetaCD) were investigated. The phase solubility profiles of cefdinir with betaCD and HPbetaCD were classified as A(L)-type, which indicates the formation of 1:1 stoichiometry inclusion complexes. Stability constants with 1:1 molar ratio obtained from the phase solubility diagrams were 120.38+/-1.07 and 58.60+/-1.20 M(-1) for betaCD and HPbetaCD, respectively. Binary systems of CEF with betaCD and HPbetaCD prepared by kneading method were characterized by Fourier transformation-infrared spectroscopy (FTIR) and X-ray powder diffractometry (XRD). The aqueous solubility of CEF was enhanced by 101% for betaCD and 23.4% for HPbetaCD, respectively. The dissolution profiles of inclusion complexes were determined and compared with those of CEF alone and their physical mixtures. The dissolution rate of CEF was increased by betaCD and HPbetaCD inclusion complexation moderately. However, the antimicrobial activity of CEF was increased significantly (p<0.001) by betaCD and HPbetaCD inclusion complexation against S. aureus and E. coli. In all these studies, HPbetaCD had superior antimicrobial activity than that of betaCD while betaCD had greater effect on solubility enhancement of CEF.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra 415124, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18367363

Citation

Aleem, Omair, et al. "Effect of Beta-cyclodextrin and Hydroxypropyl Beta-cyclodextrin Complexation On Physicochemical Properties and Antimicrobial Activity of Cefdinir." Journal of Pharmaceutical and Biomedical Analysis, vol. 47, no. 3, 2008, pp. 535-40.
Aleem O, Kuchekar B, Pore Y, et al. Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir. J Pharm Biomed Anal. 2008;47(3):535-40.
Aleem, O., Kuchekar, B., Pore, Y., & Late, S. (2008). Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir. Journal of Pharmaceutical and Biomedical Analysis, 47(3), 535-40. https://doi.org/10.1016/j.jpba.2008.02.006
Aleem O, et al. Effect of Beta-cyclodextrin and Hydroxypropyl Beta-cyclodextrin Complexation On Physicochemical Properties and Antimicrobial Activity of Cefdinir. J Pharm Biomed Anal. 2008 Jul 15;47(3):535-40. PubMed PMID: 18367363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir. AU - Aleem,Omair, AU - Kuchekar,Bhanudas, AU - Pore,Yogesh, AU - Late,Sameer, Y1 - 2008/02/15/ PY - 2007/09/14/received PY - 2007/12/19/revised PY - 2008/02/11/accepted PY - 2008/3/28/pubmed PY - 2008/9/10/medline PY - 2008/3/28/entrez SP - 535 EP - 40 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 47 IS - 3 N2 - The solid-state properties, dissolution profile and antimicrobial activity of inclusion complexes of cefdinir (CEF) with beta-cyclodextrin (betaCD) and hydroxypropyl beta-cyclodextrin (HPbetaCD) were investigated. The phase solubility profiles of cefdinir with betaCD and HPbetaCD were classified as A(L)-type, which indicates the formation of 1:1 stoichiometry inclusion complexes. Stability constants with 1:1 molar ratio obtained from the phase solubility diagrams were 120.38+/-1.07 and 58.60+/-1.20 M(-1) for betaCD and HPbetaCD, respectively. Binary systems of CEF with betaCD and HPbetaCD prepared by kneading method were characterized by Fourier transformation-infrared spectroscopy (FTIR) and X-ray powder diffractometry (XRD). The aqueous solubility of CEF was enhanced by 101% for betaCD and 23.4% for HPbetaCD, respectively. The dissolution profiles of inclusion complexes were determined and compared with those of CEF alone and their physical mixtures. The dissolution rate of CEF was increased by betaCD and HPbetaCD inclusion complexation moderately. However, the antimicrobial activity of CEF was increased significantly (p<0.001) by betaCD and HPbetaCD inclusion complexation against S. aureus and E. coli. In all these studies, HPbetaCD had superior antimicrobial activity than that of betaCD while betaCD had greater effect on solubility enhancement of CEF. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/18367363/Effect_of_beta_cyclodextrin_and_hydroxypropyl_beta_cyclodextrin_complexation_on_physicochemical_properties_and_antimicrobial_activity_of_cefdinir_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(08)00106-4 DB - PRIME DP - Unbound Medicine ER -