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Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults.
Neurology 2008; 70(18):1594-600Neur

Abstract

BACKGROUND

Characterization of the behavioral correlates of neuromorphometry and neurochemistry in older adults has important implications for an improved understanding of the aging process. The objective of this study was to test the hypothesis that a measure of hippocampal neuronal metabolism was associated with verbal memory in nondemented older adults after controlling for hippocampal volume.

METHODS

4-T MRI, proton magnetic resonance spectroscopy ((1)H MRS), and neuropsychological assessment were conducted in 48 older adults (23 women; mean age 81 years). Average hippocampal N-acetyl aspartate/creatine ratios (NAA/Cr) and hippocampal volumes were obtained. Neuropsychological evaluation included tests of verbal memory (Buschke and Grober Free and Cued Selective Reminding Test-Immediate Recall [FCSRT-IR], Wechsler Memory Scale-Revised Logical Memory subtest) and attention and executive function (Trail Making Test Parts A and B).

RESULTS

Linear regression analysis indicated that after adjusting for age, hippocampal NAA/Cr was a significant predictor of FCSRT-IR performance (beta = 0.38, p = 0.01, R (2) = 0.21). Hippocampal volume was also a significant predictor of FCSRT-IR performance after adjusting for age and midsagittal area (beta = 0.47, p = 0.01, R (2) = 0.24). In a combined model, hippocampal NAA/Cr (beta = 0.33, p = 0.03) and volume (beta = 0.35, p = 0.03) were independent predictors of FCSRT-IR performance, accounting for 30% of the variance in memory.

CONCLUSIONS

These findings indicate that nondemented older adults with smaller hippocampal volumes and lower levels of hippocampal N-acetyl aspartate/creatine ratio metabolites perform more poorly on a test of verbal memory. The integrity of both the structure and metabolism of the hippocampus may underlie verbal memory function in nondemented elderly.

Authors+Show Affiliations

Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, 1165 Morris Park Ave., Room 343, Bronx, NY 10461, USA. mzimmerm@aecom.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18367703

Citation

Zimmerman, M E., et al. "Hippocampal Neurochemistry, Neuromorphometry, and Verbal Memory in Nondemented Older Adults." Neurology, vol. 70, no. 18, 2008, pp. 1594-600.
Zimmerman ME, Pan JW, Hetherington HP, et al. Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. Neurology. 2008;70(18):1594-600.
Zimmerman, M. E., Pan, J. W., Hetherington, H. P., Katz, M. J., Verghese, J., Buschke, H., ... Lipton, R. B. (2008). Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. Neurology, 70(18), pp. 1594-600. doi:10.1212/01.wnl.0000306314.77311.be.
Zimmerman ME, et al. Hippocampal Neurochemistry, Neuromorphometry, and Verbal Memory in Nondemented Older Adults. Neurology. 2008 Apr 29;70(18):1594-600. PubMed PMID: 18367703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. AU - Zimmerman,M E, AU - Pan,J W, AU - Hetherington,H P, AU - Katz,M J, AU - Verghese,J, AU - Buschke,H, AU - Derby,C A, AU - Lipton,R B, Y1 - 2008/03/26/ PY - 2008/3/28/pubmed PY - 2008/5/24/medline PY - 2008/3/28/entrez SP - 1594 EP - 600 JF - Neurology JO - Neurology VL - 70 IS - 18 N2 - BACKGROUND: Characterization of the behavioral correlates of neuromorphometry and neurochemistry in older adults has important implications for an improved understanding of the aging process. The objective of this study was to test the hypothesis that a measure of hippocampal neuronal metabolism was associated with verbal memory in nondemented older adults after controlling for hippocampal volume. METHODS: 4-T MRI, proton magnetic resonance spectroscopy ((1)H MRS), and neuropsychological assessment were conducted in 48 older adults (23 women; mean age 81 years). Average hippocampal N-acetyl aspartate/creatine ratios (NAA/Cr) and hippocampal volumes were obtained. Neuropsychological evaluation included tests of verbal memory (Buschke and Grober Free and Cued Selective Reminding Test-Immediate Recall [FCSRT-IR], Wechsler Memory Scale-Revised Logical Memory subtest) and attention and executive function (Trail Making Test Parts A and B). RESULTS: Linear regression analysis indicated that after adjusting for age, hippocampal NAA/Cr was a significant predictor of FCSRT-IR performance (beta = 0.38, p = 0.01, R (2) = 0.21). Hippocampal volume was also a significant predictor of FCSRT-IR performance after adjusting for age and midsagittal area (beta = 0.47, p = 0.01, R (2) = 0.24). In a combined model, hippocampal NAA/Cr (beta = 0.33, p = 0.03) and volume (beta = 0.35, p = 0.03) were independent predictors of FCSRT-IR performance, accounting for 30% of the variance in memory. CONCLUSIONS: These findings indicate that nondemented older adults with smaller hippocampal volumes and lower levels of hippocampal N-acetyl aspartate/creatine ratio metabolites perform more poorly on a test of verbal memory. The integrity of both the structure and metabolism of the hippocampus may underlie verbal memory function in nondemented elderly. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/18367703/Hippocampal_neurochemistry_neuromorphometry_and_verbal_memory_in_nondemented_older_adults_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=18367703 DB - PRIME DP - Unbound Medicine ER -