Tags

Type your tag names separated by a space and hit enter

[The significance of anti-HBc and occult hepatitis B virus infection in the occurrence of hepatocellular carcinoma in patients with HBsAg and anti-HCV negative alcoholic cirrhosis].
Korean J Hepatol 2008; 14(1):67-76KJ

Abstract

BACKGROUND/AIMS

Alcohol and the hepatitis B virus (HBV) exert synergistic effects in hepatocelluar carcinogenesis. We aimed to elucidate the clinical significance of the antibody to hepatitis B core antigen (anti-HBc) and occult HBV infection on the development of hepatocellular carcinoma (HCC) in patients with alcoholic liver cirrhosis (LC).

METHODS

Patients with alcoholic LC alone (n=193) or combined with HCC (n=36), who did not have HBsAg or antibody to hepatitis C virus were enrolled. Clinical data and laboratory data including anti-HBc were investigated at enrollment. The polymerase chain reaction was applied to HBV DNA using sera of patients with HCC or LC after age and sex matching.

RESULTS

Patients with HCC were older (60+/-11 years vs. 53+/-10 years, mean+/-SD, P<0.001), more likely to be male (100% vs. 89%, P=0.03), and had a higher positive rate of anti-HBc (91.2% vs. 77.3%, P=0.067), and a higher alcohol intake (739+/-448 kg vs. 603+/-409 kg, P=0.076) than those with LC. Age was the only significant risk factor for HCC revealed by multiple logistic regression analysis (odds ratio, 1.056; P=0.003). The positive rate of anti-HBc and alcohol intake did not differ in age- and sex-matched subjects between the LC (n=32) and HCC (n=31) groups. However, the detection rate of serum HBV DNA was higher in the HCC group (48.4%) than in the LC group (0%, P<0.001).

CONCLUSIONS

Anti-HBc positivity is not a risk factor for HCC. However, occult HBV infection may be a risk factor for HCC in patients with alcoholic LC.

Authors+Show Affiliations

Department of Internal Medicine, Gachon Medical School Gil Medical Center, Incheon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

kor

PubMed ID

18367859

Citation

Kim, Min Ju, et al. "[The Significance of anti-HBc and Occult Hepatitis B Virus Infection in the Occurrence of Hepatocellular Carcinoma in Patients With HBsAg and anti-HCV Negative Alcoholic Cirrhosis]." The Korean Journal of Hepatology, vol. 14, no. 1, 2008, pp. 67-76.
Kim MJ, Kwon OS, Chung NS, et al. [The significance of anti-HBc and occult hepatitis B virus infection in the occurrence of hepatocellular carcinoma in patients with HBsAg and anti-HCV negative alcoholic cirrhosis]. Korean J Hepatol. 2008;14(1):67-76.
Kim, M. J., Kwon, O. S., Chung, N. S., Lee, S. Y., Jung, H. S., Park, D. K., ... Kim, J. H. (2008). [The significance of anti-HBc and occult hepatitis B virus infection in the occurrence of hepatocellular carcinoma in patients with HBsAg and anti-HCV negative alcoholic cirrhosis]. The Korean Journal of Hepatology, 14(1), pp. 67-76. doi:10.3350/kjhep.2008.14.1.67.
Kim MJ, et al. [The Significance of anti-HBc and Occult Hepatitis B Virus Infection in the Occurrence of Hepatocellular Carcinoma in Patients With HBsAg and anti-HCV Negative Alcoholic Cirrhosis]. Korean J Hepatol. 2008;14(1):67-76. PubMed PMID: 18367859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The significance of anti-HBc and occult hepatitis B virus infection in the occurrence of hepatocellular carcinoma in patients with HBsAg and anti-HCV negative alcoholic cirrhosis]. AU - Kim,Min Ju, AU - Kwon,Oh Sang, AU - Chung,Nak So, AU - Lee,Seo Young, AU - Jung,Hyuk Sang, AU - Park,Dong Kyun, AU - Ku,Yang Suh, AU - Kim,Yu Kyung, AU - Kim,Yun Soo, AU - Kim,Ju Hyun, PY - 2008/3/28/pubmed PY - 2008/12/17/medline PY - 2008/3/28/entrez SP - 67 EP - 76 JF - The Korean journal of hepatology JO - Korean J Hepatol VL - 14 IS - 1 N2 - BACKGROUND/AIMS: Alcohol and the hepatitis B virus (HBV) exert synergistic effects in hepatocelluar carcinogenesis. We aimed to elucidate the clinical significance of the antibody to hepatitis B core antigen (anti-HBc) and occult HBV infection on the development of hepatocellular carcinoma (HCC) in patients with alcoholic liver cirrhosis (LC). METHODS: Patients with alcoholic LC alone (n=193) or combined with HCC (n=36), who did not have HBsAg or antibody to hepatitis C virus were enrolled. Clinical data and laboratory data including anti-HBc were investigated at enrollment. The polymerase chain reaction was applied to HBV DNA using sera of patients with HCC or LC after age and sex matching. RESULTS: Patients with HCC were older (60+/-11 years vs. 53+/-10 years, mean+/-SD, P<0.001), more likely to be male (100% vs. 89%, P=0.03), and had a higher positive rate of anti-HBc (91.2% vs. 77.3%, P=0.067), and a higher alcohol intake (739+/-448 kg vs. 603+/-409 kg, P=0.076) than those with LC. Age was the only significant risk factor for HCC revealed by multiple logistic regression analysis (odds ratio, 1.056; P=0.003). The positive rate of anti-HBc and alcohol intake did not differ in age- and sex-matched subjects between the LC (n=32) and HCC (n=31) groups. However, the detection rate of serum HBV DNA was higher in the HCC group (48.4%) than in the LC group (0%, P<0.001). CONCLUSIONS: Anti-HBc positivity is not a risk factor for HCC. However, occult HBV infection may be a risk factor for HCC in patients with alcoholic LC. SN - 1738-222X UR - https://www.unboundmedicine.com/medline/citation/18367859/[The_significance_of_anti_HBc_and_occult_hepatitis_B_virus_infection_in_the_occurrence_of_hepatocellular_carcinoma_in_patients_with_HBsAg_and_anti_HCV_negative_alcoholic_cirrhosis]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -