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[Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis].
Korean J Hepatol 2008; 14(1):77-88KJ

Abstract

BACKGROUND/AIMS

Non-alcoholic fatty liver disease (NAFLD) is closely associated with abdominal obesity, dyslipidemia, hypertension, and Type 2 diabetes, which are all features of the metabolic syndrome. The aim of the present study was to elucidate whether NAFLD is associated with carotid atherosclerosis.

METHODS

The study population comprised 659 subjects without hepatitis B and C infections and who did not consume alcohol. Fatty infiltrations of liver were detected by abdominal ultrasonography, and intima-media thickness (IMT) and plaque prevalence were estimated by carotid ultrasonography.

RESULTS

The mean values of systolic and diastolic pressures, body mass index (BMI), aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, fasting glucose, fasting insulin, homeostasis model of assessment (HOMA) index, hemoglobin A1c, and plasminogen activator inhibitor-1 differed significantly between patients with NAFLD (n=314) and normal controls (n=345). The carotid IMT was 0.817+/-0.212 (mean+/-SD) mm in patients with NAFLD and 0.757+/-0.198 mm in normal controls (p<0.001). The prevalence of carotid plaques was higher in patients with NAFLD (26.4%) than in normal controls (15.9%) (p<0.001). This association persisted significantly after adjusting for age, sex, BMI, HOMA index and individual factors of metabolic syndrome by multiple logistic regression analysis.

CONCLUSIONS

Patients with NAFLD are at a high risk of carotid atherosclerosis regardless of metabolic syndrome and classical cardiovascular risk factors. Therefore, the detection of NAFLD should alert to the existence of an increased cardiovascular risk. Moreover, NAFLD might be an independent risk factor for cardiovascular disease.

Authors+Show Affiliations

Seoul National University Hospital Healthcare System Gangnam Center, Healthcare Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

kor

PubMed ID

18367860

Citation

Choi, Su-Yeon, et al. "[Nonalcoholic Fatty Liver Disease as a Risk Factor of Cardiovascular Disease: Relation of Non-alcoholic Fatty Liver Disease to Carotid Atherosclerosis]." The Korean Journal of Hepatology, vol. 14, no. 1, 2008, pp. 77-88.
Choi SY, Kim D, Kang JH, et al. [Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis]. Korean J Hepatol. 2008;14(1):77-88.
Choi, S. Y., Kim, D., Kang, J. H., Park, M. J., Kim, Y. S., Lim, S. H., ... Lee, H. S. (2008). [Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis]. The Korean Journal of Hepatology, 14(1), pp. 77-88. doi:10.3350/kjhep.2008.14.1.77.
Choi SY, et al. [Nonalcoholic Fatty Liver Disease as a Risk Factor of Cardiovascular Disease: Relation of Non-alcoholic Fatty Liver Disease to Carotid Atherosclerosis]. Korean J Hepatol. 2008;14(1):77-88. PubMed PMID: 18367860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis]. AU - Choi,Su-Yeon, AU - Kim,Donghee, AU - Kang,Jin Hwa, AU - Park,Min Jung, AU - Kim,Young Sun, AU - Lim,Seon Hee, AU - Kim,Chung Hyeon, AU - Lee,Hyo-Suk, PY - 2008/3/28/pubmed PY - 2008/12/17/medline PY - 2008/3/28/entrez SP - 77 EP - 88 JF - The Korean journal of hepatology JO - Korean J Hepatol VL - 14 IS - 1 N2 - BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is closely associated with abdominal obesity, dyslipidemia, hypertension, and Type 2 diabetes, which are all features of the metabolic syndrome. The aim of the present study was to elucidate whether NAFLD is associated with carotid atherosclerosis. METHODS: The study population comprised 659 subjects without hepatitis B and C infections and who did not consume alcohol. Fatty infiltrations of liver were detected by abdominal ultrasonography, and intima-media thickness (IMT) and plaque prevalence were estimated by carotid ultrasonography. RESULTS: The mean values of systolic and diastolic pressures, body mass index (BMI), aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, fasting glucose, fasting insulin, homeostasis model of assessment (HOMA) index, hemoglobin A1c, and plasminogen activator inhibitor-1 differed significantly between patients with NAFLD (n=314) and normal controls (n=345). The carotid IMT was 0.817+/-0.212 (mean+/-SD) mm in patients with NAFLD and 0.757+/-0.198 mm in normal controls (p<0.001). The prevalence of carotid plaques was higher in patients with NAFLD (26.4%) than in normal controls (15.9%) (p<0.001). This association persisted significantly after adjusting for age, sex, BMI, HOMA index and individual factors of metabolic syndrome by multiple logistic regression analysis. CONCLUSIONS: Patients with NAFLD are at a high risk of carotid atherosclerosis regardless of metabolic syndrome and classical cardiovascular risk factors. Therefore, the detection of NAFLD should alert to the existence of an increased cardiovascular risk. Moreover, NAFLD might be an independent risk factor for cardiovascular disease. SN - 1738-222X UR - https://www.unboundmedicine.com/medline/citation/18367860/[Nonalcoholic_fatty_liver_disease_as_a_risk_factor_of_cardiovascular_disease:_relation_of_non_alcoholic_fatty_liver_disease_to_carotid_atherosclerosis]_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -