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Analytical techniques for drug detection in oral fluid.
Ther Drug Monit. 2008 Apr; 30(2):181-7.TD

Abstract

Analytical techniques for detection of drugs in oral fluid (OF) are reviewed with emphasis on applications used in European Union (EU) roadside testing projects. Oral fluid is readily accessible and collectible. It has become an interesting material because no medical personnel are needed for sampling. This matrix is especially applicable for preliminary drug testing in driving under the influence controls and for monitoring illicit drug use in drug treatment. Oral fluid is also an increasingly used specimen in epidemiologic studies and in workplace drug testing. Drugs are present at lower levels in OF than in urine. The window of detection of drugs in OF reflects the corresponding window in blood, suggesting OF as a specimen of choice for roadside testing. Saliva/blood ratios vary from drug to drug, from person to person, and even intraindividually making therapeutic drug monitoring in OF challenging. Several sensitive methods for drug testing in OF have been developed during the last years.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lillsunde P
National Public Health Institute, Drug Research Unit, Helsinki, Finland. pirjo.lillsunde@ktl.fi

MeSH

Automobile DrivingChromatography, GasChromatography, LiquidEuropean UnionHumansIllicit DrugsImmunoassayMass SpectrometryReproducibility of ResultsSalivaSensitivity and SpecificitySpecimen HandlingSubstance Abuse DetectionSubstance-Related Disorders

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18367978

Citation

Lillsunde, Pirjo. "Analytical Techniques for Drug Detection in Oral Fluid." Therapeutic Drug Monitoring, vol. 30, no. 2, 2008, pp. 181-7.
Lillsunde P. Analytical techniques for drug detection in oral fluid. Ther Drug Monit. 2008;30(2):181-7.
Lillsunde, P. (2008). Analytical techniques for drug detection in oral fluid. Therapeutic Drug Monitoring, 30(2), 181-7. https://doi.org/10.1097/FTD.0b013e3181685088
Lillsunde P. Analytical Techniques for Drug Detection in Oral Fluid. Ther Drug Monit. 2008;30(2):181-7. PubMed PMID: 18367978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical techniques for drug detection in oral fluid. A1 - Lillsunde,Pirjo, PY - 2008/3/28/pubmed PY - 2008/7/12/medline PY - 2008/3/28/entrez SP - 181 EP - 7 JF - Therapeutic drug monitoring JO - Ther Drug Monit VL - 30 IS - 2 N2 - Analytical techniques for detection of drugs in oral fluid (OF) are reviewed with emphasis on applications used in European Union (EU) roadside testing projects. Oral fluid is readily accessible and collectible. It has become an interesting material because no medical personnel are needed for sampling. This matrix is especially applicable for preliminary drug testing in driving under the influence controls and for monitoring illicit drug use in drug treatment. Oral fluid is also an increasingly used specimen in epidemiologic studies and in workplace drug testing. Drugs are present at lower levels in OF than in urine. The window of detection of drugs in OF reflects the corresponding window in blood, suggesting OF as a specimen of choice for roadside testing. Saliva/blood ratios vary from drug to drug, from person to person, and even intraindividually making therapeutic drug monitoring in OF challenging. Several sensitive methods for drug testing in OF have been developed during the last years. SN - 0163-4356 UR - https://www.unboundmedicine.com/medline/citation/18367978/Analytical_techniques_for_drug_detection_in_oral_fluid_ DB - PRIME DP - Unbound Medicine ER -