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Nonalcoholic steatohepatitis and the metabolic syndrome.
Metab Syndr Relat Disord. 2008 Mar; 6(1):1-7.MS

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression are poorly understood. NASH is closely associated with obesity and the metabolic syndrome. Recent studies emphasize the role of insulin resistance, oxidative stress, lipid peroxidation, and cytokine release in the development of NASH. This review summarizes the current knowledge on the etiology and pathomechanism of NASH and the role of the metabolic syndrome in NASH development.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, University of California Davis, Sacramento, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18370830

Citation

Jiang, Joy, and Natalie Torok. "Nonalcoholic Steatohepatitis and the Metabolic Syndrome." Metabolic Syndrome and Related Disorders, vol. 6, no. 1, 2008, pp. 1-7.
Jiang J, Torok N. Nonalcoholic steatohepatitis and the metabolic syndrome. Metab Syndr Relat Disord. 2008;6(1):1-7.
Jiang, J., & Torok, N. (2008). Nonalcoholic steatohepatitis and the metabolic syndrome. Metabolic Syndrome and Related Disorders, 6(1), 1-7. https://doi.org/10.1089/met.2007.0026
Jiang J, Torok N. Nonalcoholic Steatohepatitis and the Metabolic Syndrome. Metab Syndr Relat Disord. 2008;6(1):1-7. PubMed PMID: 18370830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic steatohepatitis and the metabolic syndrome. AU - Jiang,Joy, AU - Torok,Natalie, PY - 2008/3/29/pubmed PY - 2008/6/6/medline PY - 2008/3/29/entrez SP - 1 EP - 7 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 6 IS - 1 N2 - Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression are poorly understood. NASH is closely associated with obesity and the metabolic syndrome. Recent studies emphasize the role of insulin resistance, oxidative stress, lipid peroxidation, and cytokine release in the development of NASH. This review summarizes the current knowledge on the etiology and pathomechanism of NASH and the role of the metabolic syndrome in NASH development. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/18370830/Nonalcoholic_steatohepatitis_and_the_metabolic_syndrome_ L2 - https://www.liebertpub.com/doi/full/10.1089/met.2007.0026?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -