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The reference limits and cut-off value for serum soluble transferrin receptors for diagnosing iron deficiency in infants.
Int J Lab Hematol. 2009 Aug; 31(4):440-6.IJ

Abstract

Serum soluble transferrin receptors (sTfR) concentration is a useful test in the diagnosis of childhood iron deficiency (ID). The aims of this study were to establish reference limits and to evaluate the diagnostic characteristics of sTfR in the diagnosis of ID in infants aged 9-12 months. In addition to mean erythrocyte cell volume, haemoglobin and ferritin measurements, sTfR concentration was measured in 179 healthy children in Estonia using the IDeA and Tina-quant methods. Using the ID criteria of ferritin <10 microg/l, subjects were divided into healthy (n = 146) and ID (n = 33) groups. The reference limits (5th and 95th percentile) were calculated in the study group. We used receiver operating characteristic curves to find out the cut-off values for the best diagnostic characteristics. The reference limits for sTfR were 1.5-2.7 mg/l in the IDeA method and 4.1-7.8 mg/l in the Tina-quant) method. The methods had poor agreement, the mean ratio with 95% limits of agreement was 2.9 (2.4-3.6). The best cut-off value in order to identify ID by hypoferritinaemia in this population is an sTfR level > 2.4 mg/l in the IDeA (sensitivity 84%, specificity 94%) and an sTfR level > 7.4 mg/l in the Tina-quant (sensitivity 80%, specificity 92%). We conclude that sTfR concentration is an efficient tool in the diagnosis of ID, but that every method needs its own cut-off value.

Authors+Show Affiliations

Department of Paediatrics, University of Tartu, Tartu, Estonia. neve.vendt@kliinikum.eeNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18371055

Citation

Vendt, N, et al. "The Reference Limits and Cut-off Value for Serum Soluble Transferrin Receptors for Diagnosing Iron Deficiency in Infants." International Journal of Laboratory Hematology, vol. 31, no. 4, 2009, pp. 440-6.
Vendt N, Talvik T, Leedo S, et al. The reference limits and cut-off value for serum soluble transferrin receptors for diagnosing iron deficiency in infants. Int J Lab Hematol. 2009;31(4):440-6.
Vendt, N., Talvik, T., Leedo, S., Tomberg, K., Kool, P., Tillmann, V., & Grünberg, H. (2009). The reference limits and cut-off value for serum soluble transferrin receptors for diagnosing iron deficiency in infants. International Journal of Laboratory Hematology, 31(4), 440-6. https://doi.org/10.1111/j.1751-553X.2008.01060.x
Vendt N, et al. The Reference Limits and Cut-off Value for Serum Soluble Transferrin Receptors for Diagnosing Iron Deficiency in Infants. Int J Lab Hematol. 2009;31(4):440-6. PubMed PMID: 18371055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The reference limits and cut-off value for serum soluble transferrin receptors for diagnosing iron deficiency in infants. AU - Vendt,N, AU - Talvik,T, AU - Leedo,S, AU - Tomberg,K, AU - Kool,P, AU - Tillmann,V, AU - Grünberg,H, Y1 - 2008/03/21/ PY - 2008/3/29/pubmed PY - 2009/9/18/medline PY - 2008/3/29/entrez SP - 440 EP - 6 JF - International journal of laboratory hematology JO - Int J Lab Hematol VL - 31 IS - 4 N2 - Serum soluble transferrin receptors (sTfR) concentration is a useful test in the diagnosis of childhood iron deficiency (ID). The aims of this study were to establish reference limits and to evaluate the diagnostic characteristics of sTfR in the diagnosis of ID in infants aged 9-12 months. In addition to mean erythrocyte cell volume, haemoglobin and ferritin measurements, sTfR concentration was measured in 179 healthy children in Estonia using the IDeA and Tina-quant methods. Using the ID criteria of ferritin <10 microg/l, subjects were divided into healthy (n = 146) and ID (n = 33) groups. The reference limits (5th and 95th percentile) were calculated in the study group. We used receiver operating characteristic curves to find out the cut-off values for the best diagnostic characteristics. The reference limits for sTfR were 1.5-2.7 mg/l in the IDeA method and 4.1-7.8 mg/l in the Tina-quant) method. The methods had poor agreement, the mean ratio with 95% limits of agreement was 2.9 (2.4-3.6). The best cut-off value in order to identify ID by hypoferritinaemia in this population is an sTfR level > 2.4 mg/l in the IDeA (sensitivity 84%, specificity 94%) and an sTfR level > 7.4 mg/l in the Tina-quant (sensitivity 80%, specificity 92%). We conclude that sTfR concentration is an efficient tool in the diagnosis of ID, but that every method needs its own cut-off value. SN - 1751-553X UR - https://www.unboundmedicine.com/medline/citation/18371055/The_reference_limits_and_cut_off_value_for_serum_soluble_transferrin_receptors_for_diagnosing_iron_deficiency_in_infants_ L2 - https://doi.org/10.1111/j.1751-553X.2008.01060.x DB - PRIME DP - Unbound Medicine ER -