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Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior.
Am J Gastroenterol 2008; 103(5):1229-39; quiz 1240AJ

Abstract

OBJECTIVE

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. The natural history of the condition has been studied extensively, but few studies have examined factors that predict its new onset or health care-seeking behavior.

METHODS

Individuals, now aged 50-59 yr, originally enrolled in a population-screening program for Helicobacter pylori (H. pylori) were contacted via postal questionnaire, utilizing the Manning criteria for IBS diagnosis. Baseline demographic data, quality of life, and IBS and dyspepsia symptom data were already on file. Consent to examine primary care records was sought, and data regarding IBS- and dyspepsia-related consultations were extracted.

RESULTS

Of 8,407 individuals originally involved, 3,873 (46%) provided symptom data at baseline and 10-yr follow-up. Of 3,659 individuals without IBS at baseline, 542 (15%) developed new-onset IBS at 10-yr follow-up. After multivariate logistic regression, lower quality of life at baseline (odds ratio [OR] 4.41, 99% confidence interval [CI] 2.92-6.65), dyspepsia at baseline (OR 1.77, 99% CI 1.28-2.46), and female gender (OR 2.14, 99% CI 1.56-2.94) were significant risk factors for new-onset IBS. Of 651 individuals with IBS at either baseline or 10-yr follow-up, 113 (17%) consulted a primary care physician with symptoms. H. pylori infection (OR 1.93, 99% CI 1.03-3.62) and any dyspepsia-related consultation (OR 2.14, 99% CI 1.15-4.00) significantly increased the likelihood of consultation.

CONCLUSIONS

Poor quality of life at baseline was a strong predictor of new-onset IBS, but not of IBS-related consultation behavior, which was associated with consultation for dyspepsia during the study period.

Authors+Show Affiliations

Centre for Digestive Diseases, Leeds General Infirmary, Great George Street, Leeds, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18371141

Citation

Ford, Alexander C., et al. "Irritable Bowel Syndrome: a 10-yr Natural History of Symptoms and Factors That Influence Consultation Behavior." The American Journal of Gastroenterology, vol. 103, no. 5, 2008, pp. 1229-39; quiz 1240.
Ford AC, Forman D, Bailey AG, et al. Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior. Am J Gastroenterol. 2008;103(5):1229-39; quiz 1240.
Ford, A. C., Forman, D., Bailey, A. G., Axon, A. T., & Moayyedi, P. (2008). Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior. The American Journal of Gastroenterology, 103(5), pp. 1229-39; quiz 1240. doi:10.1111/j.1572-0241.2007.01740.x.
Ford AC, et al. Irritable Bowel Syndrome: a 10-yr Natural History of Symptoms and Factors That Influence Consultation Behavior. Am J Gastroenterol. 2008;103(5):1229-39; quiz 1240. PubMed PMID: 18371141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior. AU - Ford,Alexander C, AU - Forman,David, AU - Bailey,Alastair G, AU - Axon,Anthony T R, AU - Moayyedi,Paul, Y1 - 2008/03/26/ PY - 2008/3/29/pubmed PY - 2008/5/31/medline PY - 2008/3/29/entrez SP - 1229-39; quiz 1240 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 103 IS - 5 N2 - OBJECTIVE: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. The natural history of the condition has been studied extensively, but few studies have examined factors that predict its new onset or health care-seeking behavior. METHODS: Individuals, now aged 50-59 yr, originally enrolled in a population-screening program for Helicobacter pylori (H. pylori) were contacted via postal questionnaire, utilizing the Manning criteria for IBS diagnosis. Baseline demographic data, quality of life, and IBS and dyspepsia symptom data were already on file. Consent to examine primary care records was sought, and data regarding IBS- and dyspepsia-related consultations were extracted. RESULTS: Of 8,407 individuals originally involved, 3,873 (46%) provided symptom data at baseline and 10-yr follow-up. Of 3,659 individuals without IBS at baseline, 542 (15%) developed new-onset IBS at 10-yr follow-up. After multivariate logistic regression, lower quality of life at baseline (odds ratio [OR] 4.41, 99% confidence interval [CI] 2.92-6.65), dyspepsia at baseline (OR 1.77, 99% CI 1.28-2.46), and female gender (OR 2.14, 99% CI 1.56-2.94) were significant risk factors for new-onset IBS. Of 651 individuals with IBS at either baseline or 10-yr follow-up, 113 (17%) consulted a primary care physician with symptoms. H. pylori infection (OR 1.93, 99% CI 1.03-3.62) and any dyspepsia-related consultation (OR 2.14, 99% CI 1.15-4.00) significantly increased the likelihood of consultation. CONCLUSIONS: Poor quality of life at baseline was a strong predictor of new-onset IBS, but not of IBS-related consultation behavior, which was associated with consultation for dyspepsia during the study period. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/18371141/Irritable_bowel_syndrome:_a_10_yr_natural_history_of_symptoms_and_factors_that_influence_consultation_behavior_ L2 - http://Insights.ovid.com/pubmed?pmid=18371141 DB - PRIME DP - Unbound Medicine ER -