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Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy.
Heart Lung. 2008 Mar-Apr; 37(2):157-60.HL

Abstract

Q fever is a zoonotic infection caused by Coxiella burnetii. The most common clinical manifestation of acute Q fever infection is as an atypical community-acquired pneumonia. The pulmonary findings are accompanied by extrapulmonary findings, most typically an increase in serum transaminases and splenomegaly. Because C. burnetii is difficult to culture, the diagnosis of Q fever is usually made serologically. The diagnosis of acute Q fever atypical community-acquired pneumonia is made by demonstrating a fourfold or greater increase in titer between acute and convalescent specimens or by demonstrating elevated immunoglobulin (IgM) (phase II) titers. Chronic Q fever is manifested as granulomatous hepatitis or more commonly as culture-negative endocarditis (CNE). Chronic Q fever (CNE) is a difficult diagnosis because of difficulty in culturing the organism from the blood and the vegetations with Q fever CNE are small or absent. The diagnosis of chronic Q fever CNE is based on serology. Such patients commonly have highly elevated IgM and IgG titers (phase I/II) titers. Chronic Q fever CNE may involve native or prosthetic heart valves. Q fever prosthetic valve endocarditis is rare compared with native valve Q fever endocarditis. Q fever prosthetic valve endocarditis usually requires valve replacement for cure. We present a case of chronic Q fever bioprosthetic aortic valve endocarditis that was successfully treated with doxycycline monotherapy that did not require aortic valve replacement.

Authors+Show Affiliations

Infectious Disease Division, Winthrop-University Hospital, Mineola, New York 11501, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18371509

Citation

Krol, Vitaliy, et al. "Q Fever Bioprosthetic Aortic Valve Endocarditis (PVE) Successfully Treated With Doxycycline Monotherapy." Heart & Lung : the Journal of Critical Care, vol. 37, no. 2, 2008, pp. 157-60.
Krol V, Kogan V, Cunha BA. Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy. Heart Lung. 2008;37(2):157-60.
Krol, V., Kogan, V., & Cunha, B. A. (2008). Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy. Heart & Lung : the Journal of Critical Care, 37(2), 157-60. https://doi.org/10.1016/j.hrtlng.2007.04.002
Krol V, Kogan V, Cunha BA. Q Fever Bioprosthetic Aortic Valve Endocarditis (PVE) Successfully Treated With Doxycycline Monotherapy. Heart Lung. 2008 Mar-Apr;37(2):157-60. PubMed PMID: 18371509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy. AU - Krol,Vitaliy, AU - Kogan,Victoria, AU - Cunha,Burke A, PY - 2007/04/02/received PY - 2007/04/09/accepted PY - 2008/3/29/pubmed PY - 2008/5/7/medline PY - 2008/3/29/entrez SP - 157 EP - 60 JF - Heart & lung : the journal of critical care JO - Heart Lung VL - 37 IS - 2 N2 - Q fever is a zoonotic infection caused by Coxiella burnetii. The most common clinical manifestation of acute Q fever infection is as an atypical community-acquired pneumonia. The pulmonary findings are accompanied by extrapulmonary findings, most typically an increase in serum transaminases and splenomegaly. Because C. burnetii is difficult to culture, the diagnosis of Q fever is usually made serologically. The diagnosis of acute Q fever atypical community-acquired pneumonia is made by demonstrating a fourfold or greater increase in titer between acute and convalescent specimens or by demonstrating elevated immunoglobulin (IgM) (phase II) titers. Chronic Q fever is manifested as granulomatous hepatitis or more commonly as culture-negative endocarditis (CNE). Chronic Q fever (CNE) is a difficult diagnosis because of difficulty in culturing the organism from the blood and the vegetations with Q fever CNE are small or absent. The diagnosis of chronic Q fever CNE is based on serology. Such patients commonly have highly elevated IgM and IgG titers (phase I/II) titers. Chronic Q fever CNE may involve native or prosthetic heart valves. Q fever prosthetic valve endocarditis is rare compared with native valve Q fever endocarditis. Q fever prosthetic valve endocarditis usually requires valve replacement for cure. We present a case of chronic Q fever bioprosthetic aortic valve endocarditis that was successfully treated with doxycycline monotherapy that did not require aortic valve replacement. SN - 1527-3288 UR - https://www.unboundmedicine.com/medline/citation/18371509/Q_fever_bioprosthetic_aortic_valve_endocarditis__PVE__successfully_treated_with_doxycycline_monotherapy_ DB - PRIME DP - Unbound Medicine ER -