Tags

Type your tag names separated by a space and hit enter

Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults.
Am J Kidney Dis. 2008 Apr; 51(4):573-83.AJ

Abstract

BACKGROUND

Prolonged analgesic consumption may adversely affect kidney function. The relation of long-term analgesic use to markers of decreased kidney function has not been investigated in the general population.

DESIGN

Cross-sectional analysis.

SETTING

National Health and Nutrition Examination Survey conducted in 1999-2002.

PARTICIPANTS

Noninstitutionalized residents at least 20 years old (n = 8,057, representing 177.8 million adults).

PREDICTORS

Ever intake of an analgesic every day for at least a month defined habitual analgesic use, classified by product (aspirin, acetaminophen, ibuprofen, and selected prescription drugs) and years of use (<1, 1 to 5, and >5 years).

OUTCOMES

Albuminuria in random urine (albumin-creatinine ratio >or= 30 mg/g; n = 1,088) and reduced estimated glomerular filtration rate (eGFR; <60 mL/min/1.73 m(2), n = 852) using the Modification of Diet in Renal Disease Study equation and the composite of either.

MEASUREMENTS

Age-standardized prevalence in habitual analgesic users and non-habitual analgesic users and multivariable-adjusted odds ratios (ORs).

RESULTS

In US adults, 23.7% (95% confidence interval [CI], 21.7 to 25.6) reported habitual analgesic use. Multivariable-adjusted ORs for reduced eGFR prevalence in adults with habitual analgesic use of acetaminophen only, ibuprofen only, and aspirin only were 1.03 (95% CI, 0.6 to 1.7), 1.21 (95% CI, 0.7 to 2.1), and 0.95 (95% CI, 0.7 to 1.2) compared with non-habitual analgesic use, respectively. Corresponding ORs for prevalent albuminuria were 0.93 (95% CI, 0.7 to 1.3), 0.65 (95% CI, 0.4 to 1.2), and 0.86 (95% CI, 0.6 to 1.2). Association measures had intermediate levels for the composite marker of decreased kidney function and were not significant. No association between prevalent outcomes and habitual analgesic exposure duration of 5 years or longer or multiple product habitual analgesic consumption was observed.

LIMITATIONS

Reliability of self-reported analgesic use behavior was not assessed.

CONCLUSIONS

Habitual analgesic use of single or multiple products was not associated with increased prevalence of albuminuria or reduced eGFR.

Authors+Show Affiliations

Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-5458, USA. agodoal@extra.niddk.nih.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18371533

Citation

Agodoa, Lawrence Y., et al. "Association of Analgesic Use With Prevalence of Albuminuria and Reduced GFR in US Adults." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 51, no. 4, 2008, pp. 573-83.
Agodoa LY, Francis ME, Eggers PW. Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults. Am J Kidney Dis. 2008;51(4):573-83.
Agodoa, L. Y., Francis, M. E., & Eggers, P. W. (2008). Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 51(4), 573-83. https://doi.org/10.1053/j.ajkd.2007.12.014
Agodoa LY, Francis ME, Eggers PW. Association of Analgesic Use With Prevalence of Albuminuria and Reduced GFR in US Adults. Am J Kidney Dis. 2008;51(4):573-83. PubMed PMID: 18371533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults. AU - Agodoa,Lawrence Y, AU - Francis,Mildred E, AU - Eggers,Paul W, Y1 - 2008/03/03/ PY - 2007/05/23/received PY - 2007/12/11/accepted PY - 2008/3/29/pubmed PY - 2008/5/29/medline PY - 2008/3/29/entrez SP - 573 EP - 83 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 51 IS - 4 N2 - BACKGROUND: Prolonged analgesic consumption may adversely affect kidney function. The relation of long-term analgesic use to markers of decreased kidney function has not been investigated in the general population. DESIGN: Cross-sectional analysis. SETTING: National Health and Nutrition Examination Survey conducted in 1999-2002. PARTICIPANTS: Noninstitutionalized residents at least 20 years old (n = 8,057, representing 177.8 million adults). PREDICTORS: Ever intake of an analgesic every day for at least a month defined habitual analgesic use, classified by product (aspirin, acetaminophen, ibuprofen, and selected prescription drugs) and years of use (<1, 1 to 5, and >5 years). OUTCOMES: Albuminuria in random urine (albumin-creatinine ratio >or= 30 mg/g; n = 1,088) and reduced estimated glomerular filtration rate (eGFR; <60 mL/min/1.73 m(2), n = 852) using the Modification of Diet in Renal Disease Study equation and the composite of either. MEASUREMENTS: Age-standardized prevalence in habitual analgesic users and non-habitual analgesic users and multivariable-adjusted odds ratios (ORs). RESULTS: In US adults, 23.7% (95% confidence interval [CI], 21.7 to 25.6) reported habitual analgesic use. Multivariable-adjusted ORs for reduced eGFR prevalence in adults with habitual analgesic use of acetaminophen only, ibuprofen only, and aspirin only were 1.03 (95% CI, 0.6 to 1.7), 1.21 (95% CI, 0.7 to 2.1), and 0.95 (95% CI, 0.7 to 1.2) compared with non-habitual analgesic use, respectively. Corresponding ORs for prevalent albuminuria were 0.93 (95% CI, 0.7 to 1.3), 0.65 (95% CI, 0.4 to 1.2), and 0.86 (95% CI, 0.6 to 1.2). Association measures had intermediate levels for the composite marker of decreased kidney function and were not significant. No association between prevalent outcomes and habitual analgesic exposure duration of 5 years or longer or multiple product habitual analgesic consumption was observed. LIMITATIONS: Reliability of self-reported analgesic use behavior was not assessed. CONCLUSIONS: Habitual analgesic use of single or multiple products was not associated with increased prevalence of albuminuria or reduced eGFR. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/18371533/Association_of_analgesic_use_with_prevalence_of_albuminuria_and_reduced_GFR_in_US_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(08)00002-4 DB - PRIME DP - Unbound Medicine ER -