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Electroanalytical investigation and determination of pefloxacin in pharmaceuticals and serum at boron-doped diamond and glassy carbon electrodes.
Talanta. 2008 Feb 15; 74(5):1191-200.T

Abstract

The anodic behavior and determination of pefloxacin on boron-doped diamond and glassy carbon electrodes were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. In cyclic voltammetry, pefloxacin shows one main irreversible oxidation peak and additional one irreversible ill-defined wave depending on pH values for both electrodes. The results indicate that the process of pefloxacin is irreversible and diffusion controlled on boron-doped diamond electrode and irreversible but adsorption controlled on glassy carbon electrode. The peak current is found to be linear over the range of concentration 2x10(-6) to 2x10(-4)M in 0.5M H(2)SO(4) at about +1.20V (versus Ag/AgCl) for differential pulse and square wave voltammetric technique using boron-doped diamond electrode. The repeatability, reproducibility, precision and accuracy of the methods in all media were investigated. Selectivity, precision and accuracy of the developed methods were also checked by recovery studies. The procedures were successfully applied to the determination of the drug in pharmaceutical dosage forms and humans serum samples with good recovery results. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage forms and biological samples, respectively.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandogan-Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18371769

Citation

Uslu, Bengi, et al. "Electroanalytical Investigation and Determination of Pefloxacin in Pharmaceuticals and Serum at Boron-doped Diamond and Glassy Carbon Electrodes." Talanta, vol. 74, no. 5, 2008, pp. 1191-200.
Uslu B, Topal BD, Ozkan SA. Electroanalytical investigation and determination of pefloxacin in pharmaceuticals and serum at boron-doped diamond and glassy carbon electrodes. Talanta. 2008;74(5):1191-200.
Uslu, B., Topal, B. D., & Ozkan, S. A. (2008). Electroanalytical investigation and determination of pefloxacin in pharmaceuticals and serum at boron-doped diamond and glassy carbon electrodes. Talanta, 74(5), 1191-200. https://doi.org/10.1016/j.talanta.2007.08.023
Uslu B, Topal BD, Ozkan SA. Electroanalytical Investigation and Determination of Pefloxacin in Pharmaceuticals and Serum at Boron-doped Diamond and Glassy Carbon Electrodes. Talanta. 2008 Feb 15;74(5):1191-200. PubMed PMID: 18371769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroanalytical investigation and determination of pefloxacin in pharmaceuticals and serum at boron-doped diamond and glassy carbon electrodes. AU - Uslu,Bengi, AU - Topal,Burcu Dogan, AU - Ozkan,Sibel A, Y1 - 2007/08/30/ PY - 2007/04/12/received PY - 2007/08/09/revised PY - 2007/08/24/accepted PY - 2008/3/29/pubmed PY - 2008/5/1/medline PY - 2008/3/29/entrez SP - 1191 EP - 200 JF - Talanta JO - Talanta VL - 74 IS - 5 N2 - The anodic behavior and determination of pefloxacin on boron-doped diamond and glassy carbon electrodes were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. In cyclic voltammetry, pefloxacin shows one main irreversible oxidation peak and additional one irreversible ill-defined wave depending on pH values for both electrodes. The results indicate that the process of pefloxacin is irreversible and diffusion controlled on boron-doped diamond electrode and irreversible but adsorption controlled on glassy carbon electrode. The peak current is found to be linear over the range of concentration 2x10(-6) to 2x10(-4)M in 0.5M H(2)SO(4) at about +1.20V (versus Ag/AgCl) for differential pulse and square wave voltammetric technique using boron-doped diamond electrode. The repeatability, reproducibility, precision and accuracy of the methods in all media were investigated. Selectivity, precision and accuracy of the developed methods were also checked by recovery studies. The procedures were successfully applied to the determination of the drug in pharmaceutical dosage forms and humans serum samples with good recovery results. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage forms and biological samples, respectively. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/18371769/Electroanalytical_investigation_and_determination_of_pefloxacin_in_pharmaceuticals_and_serum_at_boron_doped_diamond_and_glassy_carbon_electrodes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(07)00581-4 DB - PRIME DP - Unbound Medicine ER -