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The effect of signal suppression and mobile phase composition on the simultaneous analysis of multiple classes of acidic/neutral pharmaceuticals and personal care products in surface water by solid-phase extraction and ultra performance liquid chromatography-negative electrospray tandem mass spectrometry.
Talanta. 2008 Feb 15; 74(5):1299-312.T

Abstract

A new multi-residue method for the determination of 25 acidic/neutral pharmaceuticals (antibiotics, anti-inflammatory/analgesics, lipid regulating agents, diuretics, triazides, H2-receptor antagonists, cardiac glicozides and angiotensin II antagonists) and personal care products (sunscreen agents and preservatives) in surface water with the usage of a new technique: ultra performance liquid chromatography-negative electrospray tandem mass spectrometry (UPLC-MS/MS) was developed and validated. The novel UPLC system with 1.7 microm particle-packed column allowed for good resolution of analytes with the application of low mobile phase flow rates (0.05 mL min(-1)) and short retention times (from 4.7 min to 13.3 min) delivering a fast and cost-effective multi-residue method. SPE with the usage of Oasis MCX strong cation-exchange mixed-mode polymeric sorbent was chosen for sample clean-up and concentration. The influence of mobile-phase composition, matrix assisted ion suppression and SPE recovery on the sensitivity of the method was identified and quantified. The instrumental limits of quantification varied from 0.2 microgL(-1) to 30mugL(-1). The method limits of quantification were at low nanogram per litre levels and ranged from 0.3 ng L(-1) to 30 ng L(-1). The instrumental and method intra-day and inter-day repeatabilities were on average less than 5%. The method was successfully applied for the determination of PPCPs in River Taff. Thirteen compounds were determined in river water at levels ranging from a single to a few hundred nanograms per litre. Among them were ten pharmaceuticals (aspirin, salicylic acid, ketoprofen, naproxen, diclofenac, ibuprofen, mefenamic acid, furosemide, sulfasalazine and valsartan) and three personal care products (methyl- and ethylparaben and 4-benzophenone).

Authors+Show Affiliations

University of Glamorgan, Sustainable Environment Research Centre, Pontypridd CF37 1DL, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18371783

Citation

Kasprzyk-Hordern, Barbara, et al. "The Effect of Signal Suppression and Mobile Phase Composition On the Simultaneous Analysis of Multiple Classes of Acidic/neutral Pharmaceuticals and Personal Care Products in Surface Water By Solid-phase Extraction and Ultra Performance Liquid Chromatography-negative Electrospray Tandem Mass Spectrometry." Talanta, vol. 74, no. 5, 2008, pp. 1299-312.
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ. The effect of signal suppression and mobile phase composition on the simultaneous analysis of multiple classes of acidic/neutral pharmaceuticals and personal care products in surface water by solid-phase extraction and ultra performance liquid chromatography-negative electrospray tandem mass spectrometry. Talanta. 2008;74(5):1299-312.
Kasprzyk-Hordern, B., Dinsdale, R. M., & Guwy, A. J. (2008). The effect of signal suppression and mobile phase composition on the simultaneous analysis of multiple classes of acidic/neutral pharmaceuticals and personal care products in surface water by solid-phase extraction and ultra performance liquid chromatography-negative electrospray tandem mass spectrometry. Talanta, 74(5), 1299-312. https://doi.org/10.1016/j.talanta.2007.08.037
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ. The Effect of Signal Suppression and Mobile Phase Composition On the Simultaneous Analysis of Multiple Classes of Acidic/neutral Pharmaceuticals and Personal Care Products in Surface Water By Solid-phase Extraction and Ultra Performance Liquid Chromatography-negative Electrospray Tandem Mass Spectrometry. Talanta. 2008 Feb 15;74(5):1299-312. PubMed PMID: 18371783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of signal suppression and mobile phase composition on the simultaneous analysis of multiple classes of acidic/neutral pharmaceuticals and personal care products in surface water by solid-phase extraction and ultra performance liquid chromatography-negative electrospray tandem mass spectrometry. AU - Kasprzyk-Hordern,Barbara, AU - Dinsdale,Richard M, AU - Guwy,Alan J, Y1 - 2007/09/06/ PY - 2007/05/31/received PY - 2007/08/23/revised PY - 2007/08/30/accepted PY - 2008/3/29/pubmed PY - 2008/5/1/medline PY - 2008/3/29/entrez SP - 1299 EP - 312 JF - Talanta JO - Talanta VL - 74 IS - 5 N2 - A new multi-residue method for the determination of 25 acidic/neutral pharmaceuticals (antibiotics, anti-inflammatory/analgesics, lipid regulating agents, diuretics, triazides, H2-receptor antagonists, cardiac glicozides and angiotensin II antagonists) and personal care products (sunscreen agents and preservatives) in surface water with the usage of a new technique: ultra performance liquid chromatography-negative electrospray tandem mass spectrometry (UPLC-MS/MS) was developed and validated. The novel UPLC system with 1.7 microm particle-packed column allowed for good resolution of analytes with the application of low mobile phase flow rates (0.05 mL min(-1)) and short retention times (from 4.7 min to 13.3 min) delivering a fast and cost-effective multi-residue method. SPE with the usage of Oasis MCX strong cation-exchange mixed-mode polymeric sorbent was chosen for sample clean-up and concentration. The influence of mobile-phase composition, matrix assisted ion suppression and SPE recovery on the sensitivity of the method was identified and quantified. The instrumental limits of quantification varied from 0.2 microgL(-1) to 30mugL(-1). The method limits of quantification were at low nanogram per litre levels and ranged from 0.3 ng L(-1) to 30 ng L(-1). The instrumental and method intra-day and inter-day repeatabilities were on average less than 5%. The method was successfully applied for the determination of PPCPs in River Taff. Thirteen compounds were determined in river water at levels ranging from a single to a few hundred nanograms per litre. Among them were ten pharmaceuticals (aspirin, salicylic acid, ketoprofen, naproxen, diclofenac, ibuprofen, mefenamic acid, furosemide, sulfasalazine and valsartan) and three personal care products (methyl- and ethylparaben and 4-benzophenone). SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/18371783/The_effect_of_signal_suppression_and_mobile_phase_composition_on_the_simultaneous_analysis_of_multiple_classes_of_acidic/neutral_pharmaceuticals_and_personal_care_products_in_surface_water_by_solid_phase_extraction_and_ultra_performance_liquid_chromatography_negative_electrospray_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(07)00609-1 DB - PRIME DP - Unbound Medicine ER -