Tags

Type your tag names separated by a space and hit enter

Sulpha allergy in lupus patients: a clinical perspective.

Abstract

Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patients. European-American lupus patients with sulpha allergy are about two times more likely to suffer from lymphopenia, two times more likely to have anti-Ro autoantibody, and four times less likely to have anti-nRNP antibodies compared with lupus patients without a reported sulpha allergy (P = 0.0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005).

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

    , , , , ,

    Source

    Lupus 17:3 2008 Mar pg 202-5

    MeSH

    Adult
    Antibodies, Antinuclear
    Autoantibodies
    Drug Hypersensitivity
    Female
    Humans
    Lupus Erythematosus, Systemic
    Male
    Ribonucleoproteins
    Sulfonamides

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    18372360

    Citation

    Jeffries, M, et al. "Sulpha Allergy in Lupus Patients: a Clinical Perspective." Lupus, vol. 17, no. 3, 2008, pp. 202-5.
    Jeffries M, Bruner G, Glenn S, et al. Sulpha allergy in lupus patients: a clinical perspective. Lupus. 2008;17(3):202-5.
    Jeffries, M., Bruner, G., Glenn, S., Sadanandan, P., Carson, C. W., Harley, J. B., & Sawalha, A. H. (2008). Sulpha allergy in lupus patients: a clinical perspective. Lupus, 17(3), pp. 202-5. doi:10.1177/0961203307086640.
    Jeffries M, et al. Sulpha Allergy in Lupus Patients: a Clinical Perspective. Lupus. 2008;17(3):202-5. PubMed PMID: 18372360.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sulpha allergy in lupus patients: a clinical perspective. AU - Jeffries,M, AU - Bruner,G, AU - Glenn,S, AU - Sadanandan,P, AU - Carson,C W, AU - Harley,J B, AU - Sawalha,A H, PY - 2008/3/29/pubmed PY - 2008/8/13/medline PY - 2008/3/29/entrez SP - 202 EP - 5 JF - Lupus JO - Lupus VL - 17 IS - 3 N2 - Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patients. European-American lupus patients with sulpha allergy are about two times more likely to suffer from lymphopenia, two times more likely to have anti-Ro autoantibody, and four times less likely to have anti-nRNP antibodies compared with lupus patients without a reported sulpha allergy (P = 0.0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005). SN - 0961-2033 UR - https://www.unboundmedicine.com/medline/citation/18372360/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/0961203307086640?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -