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[Review: executive functioning and cannabis use].
Braz J Psychiatry 2008; 30(1):69-76BJ

Abstract

OBJECTIVE

Cannabis is the most used illicit drug worldwide, however only a few studies have examined cognitive deficits related to its use. Clinical manifestations associated with those deficits include a motivational syndrome, impairment in cognitive flexibility, inattention, deficits in abstract reasoning and concept formation, aspects intimately related to the executive functions, which potentially exert a central role in substance dependence. The objective was to make a review about consequences of cannabis use in executive functioning.

METHOD

This review was carried out on reports drawn from MedLine, SciELO, and Lilacs.

DISCUSSION

In studies investigating acute use effects, higher doses of tetrahydrocannabinol are associated to impairments in performance of nonsevere users in planning and control impulse tasks. However, chronic cannabis users do not show those impairments. Although demonstration of residual effects of cannabis in the executive functioning is controversial, persistent deficits seem to be present at least in a subgroup of chronic users after 28 days of abstinence.

CONCLUSIONS

The neuropsychological studies found did not have as a main aim the evaluation of executive functioning. A criterial selection of standardized neuropsychological tests, more appropriate study designs as well as concomitant investigations with structural and functional neuroimaging techniques may improve the understanding of eventual neurotoxicity associated with cannabis use.

Authors+Show Affiliations

Laboratório Interdisciplinar de Neurociências Clínicas, Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. priscilapreviato@yahoo.co.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

por

PubMed ID

18373021

Citation

Almeida, Priscila Previato, et al. "[Review: Executive Functioning and Cannabis Use]." Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999), vol. 30, no. 1, 2008, pp. 69-76.
Almeida PP, Novaes MA, Bressan RA, et al. [Review: executive functioning and cannabis use]. Braz J Psychiatry. 2008;30(1):69-76.
Almeida, P. P., Novaes, M. A., Bressan, R. A., & Lacerda, A. L. (2008). [Review: executive functioning and cannabis use]. Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999), 30(1), pp. 69-76.
Almeida PP, et al. [Review: Executive Functioning and Cannabis Use]. Braz J Psychiatry. 2008;30(1):69-76. PubMed PMID: 18373021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Review: executive functioning and cannabis use]. AU - Almeida,Priscila Previato, AU - Novaes,Maria Alice Fontes Pinto, AU - Bressan,Rodrigo Affonseca, AU - Lacerda,Acioly Luiz Tavares de, PY - 2007/10/29/received PY - 2008/01/17/accepted PY - 2008/4/1/pubmed PY - 2009/1/27/medline PY - 2008/4/1/entrez SP - 69 EP - 76 JF - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) JO - Braz J Psychiatry VL - 30 IS - 1 N2 - OBJECTIVE: Cannabis is the most used illicit drug worldwide, however only a few studies have examined cognitive deficits related to its use. Clinical manifestations associated with those deficits include a motivational syndrome, impairment in cognitive flexibility, inattention, deficits in abstract reasoning and concept formation, aspects intimately related to the executive functions, which potentially exert a central role in substance dependence. The objective was to make a review about consequences of cannabis use in executive functioning. METHOD: This review was carried out on reports drawn from MedLine, SciELO, and Lilacs. DISCUSSION: In studies investigating acute use effects, higher doses of tetrahydrocannabinol are associated to impairments in performance of nonsevere users in planning and control impulse tasks. However, chronic cannabis users do not show those impairments. Although demonstration of residual effects of cannabis in the executive functioning is controversial, persistent deficits seem to be present at least in a subgroup of chronic users after 28 days of abstinence. CONCLUSIONS: The neuropsychological studies found did not have as a main aim the evaluation of executive functioning. A criterial selection of standardized neuropsychological tests, more appropriate study designs as well as concomitant investigations with structural and functional neuroimaging techniques may improve the understanding of eventual neurotoxicity associated with cannabis use. SN - 1516-4446 UR - https://www.unboundmedicine.com/medline/citation/18373021/[Review:_executive_functioning_and_cannabis_use]_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462008000100013&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -