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Continuous, but not occasional, oral ethanol intake reduces the success of intraportal transplanted islets of Langerhans: an experimental study.
Transplant Proc. 2008 Mar; 40(2):441-3.TP

Abstract

BACKGROUND

Islet transplantation is gradually gaining acceptance for the treatment of type 1 diabetes mellitus. One of the unknown questions is alcohol intake; we have prohibited alcohol intake after islet transplantation although there is no solid evidence to support this.

MATERIALS AND METHODS

In this study, we employed a mouse model to determine the effect of oral ethanol intake on transplanted islets. Either 500 or 150 islets were infused selectively into the right liver lobe of chemically induced diabetic mice. After transplantation, mice were orally administered either water (as a control) or various concentrations of ethanol for 14 consecutive days occasionally (once per day) or continuously (all intake was alcohol). Blood glucose levels were monitored and oral glucose tolerance tests (OGTT) performed.

RESULTS

After 500 islets had been transplanted, all mice were cured from diabetes, but the continuous alcohol intake group showed significantly prolonged time to diabetes reversal and significantly lower glucose clearance rates by OGTT compared with the control group. After 150 islet transplantations, the diabetes cure rate in the continuous alcohol intake group was significantly lower than the control group (continuous alcohol vs control: 3/8 vs 11/12, P < .05). However, the occasional alcohol intake group showed no difference from the control group, even with as few as 150 islets transplanted per mouse.

CONCLUSION

The present results demonstrated that continuous but not occasional alcohol intake reduced the success of intraportal islet transplantation.

Authors+Show Affiliations

Department of General Surgery, First Clinical College of Harbin Medical University, Harbin, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18374095

Citation

Liu, X, et al. "Continuous, but Not Occasional, Oral Ethanol Intake Reduces the Success of Intraportal Transplanted Islets of Langerhans: an Experimental Study." Transplantation Proceedings, vol. 40, no. 2, 2008, pp. 441-3.
Liu X, Matsumoto S, Noguchi H, et al. Continuous, but not occasional, oral ethanol intake reduces the success of intraportal transplanted islets of Langerhans: an experimental study. Transplant Proc. 2008;40(2):441-3.
Liu, X., Matsumoto, S., Noguchi, H., Yonekawa, Y., Iwanaga, Y., Okitsu, T., Nagata, H., Miyakawa, S., Song, C., Jackson, A., Naziruddin, B., & Levy, M. F. (2008). Continuous, but not occasional, oral ethanol intake reduces the success of intraportal transplanted islets of Langerhans: an experimental study. Transplantation Proceedings, 40(2), 441-3. https://doi.org/10.1016/j.transproceed.2007.12.021
Liu X, et al. Continuous, but Not Occasional, Oral Ethanol Intake Reduces the Success of Intraportal Transplanted Islets of Langerhans: an Experimental Study. Transplant Proc. 2008;40(2):441-3. PubMed PMID: 18374095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous, but not occasional, oral ethanol intake reduces the success of intraportal transplanted islets of Langerhans: an experimental study. AU - Liu,X, AU - Matsumoto,S, AU - Noguchi,H, AU - Yonekawa,Y, AU - Iwanaga,Y, AU - Okitsu,T, AU - Nagata,H, AU - Miyakawa,S, AU - Song,C, AU - Jackson,A, AU - Naziruddin,B, AU - Levy,M F, PY - 2008/4/1/pubmed PY - 2008/6/25/medline PY - 2008/4/1/entrez SP - 441 EP - 3 JF - Transplantation proceedings JO - Transplant Proc VL - 40 IS - 2 N2 - BACKGROUND: Islet transplantation is gradually gaining acceptance for the treatment of type 1 diabetes mellitus. One of the unknown questions is alcohol intake; we have prohibited alcohol intake after islet transplantation although there is no solid evidence to support this. MATERIALS AND METHODS: In this study, we employed a mouse model to determine the effect of oral ethanol intake on transplanted islets. Either 500 or 150 islets were infused selectively into the right liver lobe of chemically induced diabetic mice. After transplantation, mice were orally administered either water (as a control) or various concentrations of ethanol for 14 consecutive days occasionally (once per day) or continuously (all intake was alcohol). Blood glucose levels were monitored and oral glucose tolerance tests (OGTT) performed. RESULTS: After 500 islets had been transplanted, all mice were cured from diabetes, but the continuous alcohol intake group showed significantly prolonged time to diabetes reversal and significantly lower glucose clearance rates by OGTT compared with the control group. After 150 islet transplantations, the diabetes cure rate in the continuous alcohol intake group was significantly lower than the control group (continuous alcohol vs control: 3/8 vs 11/12, P < .05). However, the occasional alcohol intake group showed no difference from the control group, even with as few as 150 islets transplanted per mouse. CONCLUSION: The present results demonstrated that continuous but not occasional alcohol intake reduced the success of intraportal islet transplantation. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/18374095/Continuous_but_not_occasional_oral_ethanol_intake_reduces_the_success_of_intraportal_transplanted_islets_of_Langerhans:_an_experimental_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(07)01504-7 DB - PRIME DP - Unbound Medicine ER -