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Prevalence and prognostic influence of peripheral arterial disease in patients >or=40 years old admitted into hospital following an acute coronary event.
Eur J Vasc Endovasc Surg. 2008 Aug; 36(2):189-96.EJ

Abstract

OBJECTIVE

A significant proportion of patients with ischemic heart disease have associated peripheral arterial disease (PAD), but many are asymptomatic and this condition remains underdiagnosed. We aimed to study the prevalence of PAD in patients with an acute coronary syndrome (ACS) and to evaluate its influence in hospital clinical outcomes.

METHODS

The PAMISCA register is a prospective, multicenter study involving patients >or=40 years old with ACS admitted to selected Spanish hospitals. All patients had their ankle-brachial index (ABI) measured between days 3 and 7 after the ischemic event.

RESULTS

1410 ACS patients (71.4% male) were included. PAD determined by ABI was documented in 561 patients (39.8%). Factors independently related to PAD were age (OR: 1.04; 95% CI: 1.03-1.06; p<0.001), smoking (OR: 1.88; 95% CI: 1.41-2.49; p<0.0001), diabetes (OR: 1.30; 95% CI: 1.02-1.65; p<0.05), previous cardiac disease (OR: 1.54; 95% CI: 1.22-1.95; p<0.001) and previous cerebrovascular disease (OR: 1.90; 95% CI: 1.28-2.80; p<0.001). Following the ACS, an ABI<or=0.90 was associated with increased cardiovascular mortality (OR: 5.45; 95% CI: 1.16-25.59; p<0.05) and a higher risk of cardiovascular complications.

CONCLUSION

The prevalence of PAD in patients >or=40 years presenting with ACS is high and it is associated with increased cardiovascular risk.

Authors+Show Affiliations

Hospital Universitario de San Juan, Alicante, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18375154

Citation

Bertomeu, V, et al. "Prevalence and Prognostic Influence of Peripheral Arterial Disease in Patients >or=40 Years Old Admitted Into Hospital Following an Acute Coronary Event." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 36, no. 2, 2008, pp. 189-96.
Bertomeu V, Morillas P, Gonzalez-Juanatey JR, et al. Prevalence and prognostic influence of peripheral arterial disease in patients >or=40 years old admitted into hospital following an acute coronary event. Eur J Vasc Endovasc Surg. 2008;36(2):189-96.
Bertomeu, V., Morillas, P., Gonzalez-Juanatey, J. R., Quiles, J., Guindo, J., Soria, F., Llacer, A., Lekuona, I., Mazón, P., Martín-Luengo, C., & Rodriguez-Padial, L. (2008). Prevalence and prognostic influence of peripheral arterial disease in patients >or=40 years old admitted into hospital following an acute coronary event. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 36(2), 189-96. https://doi.org/10.1016/j.ejvs.2008.02.004
Bertomeu V, et al. Prevalence and Prognostic Influence of Peripheral Arterial Disease in Patients >or=40 Years Old Admitted Into Hospital Following an Acute Coronary Event. Eur J Vasc Endovasc Surg. 2008;36(2):189-96. PubMed PMID: 18375154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and prognostic influence of peripheral arterial disease in patients >or=40 years old admitted into hospital following an acute coronary event. AU - Bertomeu,V, AU - Morillas,P, AU - Gonzalez-Juanatey,J R, AU - Quiles,J, AU - Guindo,J, AU - Soria,F, AU - Llacer,A, AU - Lekuona,I, AU - Mazón,P, AU - Martín-Luengo,C, AU - Rodriguez-Padial,L, AU - ,, Y1 - 2008/03/28/ PY - 2007/11/24/received PY - 2008/02/12/accepted PY - 2008/4/1/pubmed PY - 2008/8/15/medline PY - 2008/4/1/entrez SP - 189 EP - 96 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 36 IS - 2 N2 - OBJECTIVE: A significant proportion of patients with ischemic heart disease have associated peripheral arterial disease (PAD), but many are asymptomatic and this condition remains underdiagnosed. We aimed to study the prevalence of PAD in patients with an acute coronary syndrome (ACS) and to evaluate its influence in hospital clinical outcomes. METHODS: The PAMISCA register is a prospective, multicenter study involving patients >or=40 years old with ACS admitted to selected Spanish hospitals. All patients had their ankle-brachial index (ABI) measured between days 3 and 7 after the ischemic event. RESULTS: 1410 ACS patients (71.4% male) were included. PAD determined by ABI was documented in 561 patients (39.8%). Factors independently related to PAD were age (OR: 1.04; 95% CI: 1.03-1.06; p<0.001), smoking (OR: 1.88; 95% CI: 1.41-2.49; p<0.0001), diabetes (OR: 1.30; 95% CI: 1.02-1.65; p<0.05), previous cardiac disease (OR: 1.54; 95% CI: 1.22-1.95; p<0.001) and previous cerebrovascular disease (OR: 1.90; 95% CI: 1.28-2.80; p<0.001). Following the ACS, an ABI<or=0.90 was associated with increased cardiovascular mortality (OR: 5.45; 95% CI: 1.16-25.59; p<0.05) and a higher risk of cardiovascular complications. CONCLUSION: The prevalence of PAD in patients >or=40 years presenting with ACS is high and it is associated with increased cardiovascular risk. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/18375154/Prevalence_and_prognostic_influence_of_peripheral_arterial_disease_in_patients_>or=40_years_old_admitted_into_hospital_following_an_acute_coronary_event_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(08)00116-0 DB - PRIME DP - Unbound Medicine ER -