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Advances in celiac disease and gluten-free diet.
J Am Diet Assoc 2008; 108(4):661-72JA

Abstract

Celiac disease is becoming an increasingly recognized autoimmune enteropathy caused by a permanent intolerance to gluten. Once thought to be a rare disease of childhood characterized by diarrhea, celiac disease is actually a multisystemic disorder that occurs as a result of an immune response to ingested gluten in genetically predisposed individuals. Screening studies have revealed that celiac disease is most common in asymptomatic adults in the United States. Although considerable scientific progress has been made in understanding celiac disease and in preventing or curing its manifestations, a strict gluten-free diet is the only treatment for celiac disease to date. Early diagnosis and treatment, together with regular follow-up visits with a dietitian, are necessary to ensure nutritional adequacy and to prevent malnutrition while adhering to the gluten-free diet for life. The purpose of this review is to provide clinicians with current updated information about celiac disease, its diverse clinical presentation and increased prevalence, the complex pathophysiology and strong genetic predisposition to celiac disease, and its diagnosis. This review focuses in detail on the gluten-free diet and the importance of intense expert dietary counseling for all patients with celiac disease. Recent advances in the gluten-free diet include food allergen labeling as well as the US Food and Drug Administration's proposed definition of the food-labeling term gluten-free. The gluten-free diet is complex and patients need comprehensive nutrition education from a skilled dietitian.

Authors+Show Affiliations

Department of Pediatrics/Genetics, University of Illinois at Chicago Medical Center, Chicago, IL, USA. mniewins@uic.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18375224

Citation

Niewinski, Mary M.. "Advances in Celiac Disease and Gluten-free Diet." Journal of the American Dietetic Association, vol. 108, no. 4, 2008, pp. 661-72.
Niewinski MM. Advances in celiac disease and gluten-free diet. J Am Diet Assoc. 2008;108(4):661-72.
Niewinski, M. M. (2008). Advances in celiac disease and gluten-free diet. Journal of the American Dietetic Association, 108(4), pp. 661-72. doi:10.1016/j.jada.2008.01.011.
Niewinski MM. Advances in Celiac Disease and Gluten-free Diet. J Am Diet Assoc. 2008;108(4):661-72. PubMed PMID: 18375224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in celiac disease and gluten-free diet. A1 - Niewinski,Mary M, PY - 2007/03/02/received PY - 2007/10/15/accepted PY - 2008/4/1/pubmed PY - 2008/5/21/medline PY - 2008/4/1/entrez SP - 661 EP - 72 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 108 IS - 4 N2 - Celiac disease is becoming an increasingly recognized autoimmune enteropathy caused by a permanent intolerance to gluten. Once thought to be a rare disease of childhood characterized by diarrhea, celiac disease is actually a multisystemic disorder that occurs as a result of an immune response to ingested gluten in genetically predisposed individuals. Screening studies have revealed that celiac disease is most common in asymptomatic adults in the United States. Although considerable scientific progress has been made in understanding celiac disease and in preventing or curing its manifestations, a strict gluten-free diet is the only treatment for celiac disease to date. Early diagnosis and treatment, together with regular follow-up visits with a dietitian, are necessary to ensure nutritional adequacy and to prevent malnutrition while adhering to the gluten-free diet for life. The purpose of this review is to provide clinicians with current updated information about celiac disease, its diverse clinical presentation and increased prevalence, the complex pathophysiology and strong genetic predisposition to celiac disease, and its diagnosis. This review focuses in detail on the gluten-free diet and the importance of intense expert dietary counseling for all patients with celiac disease. Recent advances in the gluten-free diet include food allergen labeling as well as the US Food and Drug Administration's proposed definition of the food-labeling term gluten-free. The gluten-free diet is complex and patients need comprehensive nutrition education from a skilled dietitian. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/18375224/Advances_in_celiac_disease_and_gluten_free_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(08)00012-6 DB - PRIME DP - Unbound Medicine ER -