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Mucosal melanoma of the head and neck.
Am J Clin Oncol. 2008 Feb; 31(1):43-8.AJ

Abstract

OBJECTIVE

Outcomes after radiotherapy for head and neck mucosal melanoma (MMHN).

METHODS

From 1974 to 2005, 17 patients with primary MMHN were treated with radiotherapy. Primary sites included nasal cavity, paranasal sinuses, and oral cavity or oropharynx. Thirteen patients received surgery and postoperative radiotherapy; 4 received definitive radiotherapy.

RESULTS

Local control was 79% at 1 and 5 years for 13 of 13 patients treated with surgery and postoperative radiotherapy compared with 1 of 4 patients treated with definitive radiotherapy. Three patients recurred in the neck; 13 patients developed distant metastases. Disease-free survival was 23% at 1 year and 18% at 5 years. Absolute and cause-specific survivals were identical (53% and 28% at 1 and 5 years).

CONCLUSION

Locoregional control is relatively high after surgery and adjuvant radiotherapy, but most patients recur in distant sites; approximately one fourth of patients are cured at 5 years. Patients with unresectable tumor may be controlled with definitive radiotherapy.

Authors+Show Affiliations

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610-0385, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18376227

Citation

Wagner, Marcus, et al. "Mucosal Melanoma of the Head and Neck." American Journal of Clinical Oncology, vol. 31, no. 1, 2008, pp. 43-8.
Wagner M, Morris CG, Werning JW, et al. Mucosal melanoma of the head and neck. Am J Clin Oncol. 2008;31(1):43-8.
Wagner, M., Morris, C. G., Werning, J. W., & Mendenhall, W. M. (2008). Mucosal melanoma of the head and neck. American Journal of Clinical Oncology, 31(1), 43-8. https://doi.org/10.1097/COC.0b013e318134ee88
Wagner M, et al. Mucosal Melanoma of the Head and Neck. Am J Clin Oncol. 2008;31(1):43-8. PubMed PMID: 18376227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucosal melanoma of the head and neck. AU - Wagner,Marcus, AU - Morris,Christopher G, AU - Werning,John W, AU - Mendenhall,William M, PY - 2008/4/1/pubmed PY - 2008/4/23/medline PY - 2008/4/1/entrez SP - 43 EP - 8 JF - American journal of clinical oncology JO - Am J Clin Oncol VL - 31 IS - 1 N2 - OBJECTIVE: Outcomes after radiotherapy for head and neck mucosal melanoma (MMHN). METHODS: From 1974 to 2005, 17 patients with primary MMHN were treated with radiotherapy. Primary sites included nasal cavity, paranasal sinuses, and oral cavity or oropharynx. Thirteen patients received surgery and postoperative radiotherapy; 4 received definitive radiotherapy. RESULTS: Local control was 79% at 1 and 5 years for 13 of 13 patients treated with surgery and postoperative radiotherapy compared with 1 of 4 patients treated with definitive radiotherapy. Three patients recurred in the neck; 13 patients developed distant metastases. Disease-free survival was 23% at 1 year and 18% at 5 years. Absolute and cause-specific survivals were identical (53% and 28% at 1 and 5 years). CONCLUSION: Locoregional control is relatively high after surgery and adjuvant radiotherapy, but most patients recur in distant sites; approximately one fourth of patients are cured at 5 years. Patients with unresectable tumor may be controlled with definitive radiotherapy. SN - 1537-453X UR - https://www.unboundmedicine.com/medline/citation/18376227/Mucosal_melanoma_of_the_head_and_neck_ L2 - https://doi.org/10.1097/COC.0b013e318134ee88 DB - PRIME DP - Unbound Medicine ER -