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Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders?
J Pediatr Gastroenterol Nutr. 2008 Mar; 46(3):272-8.JP

Abstract

BACKGROUND

Abdominal pain related to irritable bowel syndrome (IBS) and functional abdominal pain (FAP) is frequent in children and can be of variable severity. Both IBS and FAP are associated with rectal hypersensitivity. We hypothesized that in children with IBS and FAP, the rectal sensory threshold for pain (RSTP) is associated with symptom severity.

PATIENTS AND METHODS

A total of 47 patients (34 girls; median age, 14.2 years) with IBS (n = 29) and FAP (n = 18), according to the Rome II criteria, underwent a rectal barostat examination to determine their RSTP. Gastrointestinal symptom severity was assessed by validated questionnaires. During the rectal barostat exam, symptoms were documented using a visual analog scale and by measuring the area coloured on a human body diagram corresponding to painful sensations.

RESULTS

The median RSTP was 16 mmHg and was similar in IBS and FAP patients. Eighty-three percent of the patients had rectal hypersensitivity (RSTP < or = 30.8 mmHg, the 5th percentile of control children studied in our laboratory). Fifty-one percent and 36%, respectively, reported missing school and social activities at least once per week. Increased frequency of pain, missed days of school, missed social activities, and pain during the barostat examination were not associated with lower RSTP values in either the whole group or in the subset of children with rectal hypersensitivity.

CONCLUSIONS

Rectal hypersensitivity is not proportional to the severity of symptoms in children with IBS and FAP, indicating that symptom severity is influenced by other factors in addition to visceral hypersensitivity.

Authors+Show Affiliations

Department of Pediatrics, Division of Pediatric Gastroenterology, Hôpital Sainte-Justine, Université de Montréal, Montréal, Quebec, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18376243

Citation

Castilloux, Julie, et al. "Is Visceral Hypersensitivity Correlated With Symptom Severity in Children With Functional Gastrointestinal Disorders?" Journal of Pediatric Gastroenterology and Nutrition, vol. 46, no. 3, 2008, pp. 272-8.
Castilloux J, Noble A, Faure C. Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders? J Pediatr Gastroenterol Nutr. 2008;46(3):272-8.
Castilloux, J., Noble, A., & Faure, C. (2008). Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders? Journal of Pediatric Gastroenterology and Nutrition, 46(3), 272-8. https://doi.org/10.1097/MPG.0b013e31814b91e7
Castilloux J, Noble A, Faure C. Is Visceral Hypersensitivity Correlated With Symptom Severity in Children With Functional Gastrointestinal Disorders. J Pediatr Gastroenterol Nutr. 2008;46(3):272-8. PubMed PMID: 18376243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders? AU - Castilloux,Julie, AU - Noble,Angela, AU - Faure,Christophe, PY - 2008/4/1/pubmed PY - 2008/5/10/medline PY - 2008/4/1/entrez SP - 272 EP - 8 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 46 IS - 3 N2 - BACKGROUND: Abdominal pain related to irritable bowel syndrome (IBS) and functional abdominal pain (FAP) is frequent in children and can be of variable severity. Both IBS and FAP are associated with rectal hypersensitivity. We hypothesized that in children with IBS and FAP, the rectal sensory threshold for pain (RSTP) is associated with symptom severity. PATIENTS AND METHODS: A total of 47 patients (34 girls; median age, 14.2 years) with IBS (n = 29) and FAP (n = 18), according to the Rome II criteria, underwent a rectal barostat examination to determine their RSTP. Gastrointestinal symptom severity was assessed by validated questionnaires. During the rectal barostat exam, symptoms were documented using a visual analog scale and by measuring the area coloured on a human body diagram corresponding to painful sensations. RESULTS: The median RSTP was 16 mmHg and was similar in IBS and FAP patients. Eighty-three percent of the patients had rectal hypersensitivity (RSTP < or = 30.8 mmHg, the 5th percentile of control children studied in our laboratory). Fifty-one percent and 36%, respectively, reported missing school and social activities at least once per week. Increased frequency of pain, missed days of school, missed social activities, and pain during the barostat examination were not associated with lower RSTP values in either the whole group or in the subset of children with rectal hypersensitivity. CONCLUSIONS: Rectal hypersensitivity is not proportional to the severity of symptoms in children with IBS and FAP, indicating that symptom severity is influenced by other factors in addition to visceral hypersensitivity. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/18376243/Is_visceral_hypersensitivity_correlated_with_symptom_severity_in_children_with_functional_gastrointestinal_disorders L2 - https://doi.org/10.1097/MPG.0b013e31814b91e7 DB - PRIME DP - Unbound Medicine ER -