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[Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia].

Abstract

The purpose of the study was to describe hypothalamopituitary functional status of females with infertility in combination with hyperprolactinemia. To this end, changes in prolactin, LH, FSH and TSH in response to the administration of releasing hormones (Gn--RH and TRH) and the dopamine antagonist metoclopramide were assessed in 28 patients with hyperprolactinemic amenorrhea and 5 normal cycling women. Lactotrophs were found to be resistant to functional tests, the resistance increasing as the prolactin level went up. Gonadotrophic and thyrotrophic response to functional tests, on the contrary, increased with the progress of hyperprolactinemia. A conclusion is drawn that stable hyperprolactinemia is a result of disturbance in lactotrophic receptor apparatus, for which reason lactotrophs are no longer sensitive to dophamine inhibiting effect on prolactin secretion.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

1837659

Citation

Stepanskaia, N V., et al. "[Disorders of the Hypothalamo-hypophyseal System as a Cause of Infertility in Hyperprolactinemia]." Acta Universitatis Palackianae Olomucensis Facultatis Medicae, vol. 129, 1991, pp. 163-73.
Stepanskaia NV, Ovsiannikova TV, Pshenichnikova TIa. [Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia]. Acta Univ Palacki Olomuc Fac Med. 1991;129:163-73.
Stepanskaia, N. V., Ovsiannikova, T. V., & Pshenichnikova, T. I. a. (1991). [Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia]. Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 129, 163-73.
Stepanskaia NV, Ovsiannikova TV, Pshenichnikova TIa. [Disorders of the Hypothalamo-hypophyseal System as a Cause of Infertility in Hyperprolactinemia]. Acta Univ Palacki Olomuc Fac Med. 1991;129:163-73. PubMed PMID: 1837659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia]. AU - Stepanskaia,N V, AU - Ovsiannikova,T V, AU - Pshenichnikova,T Ia, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 163 EP - 73 JF - Acta Universitatis Palackianae Olomucensis Facultatis Medicae JO - Acta Univ Palacki Olomuc Fac Med VL - 129 N2 - The purpose of the study was to describe hypothalamopituitary functional status of females with infertility in combination with hyperprolactinemia. To this end, changes in prolactin, LH, FSH and TSH in response to the administration of releasing hormones (Gn--RH and TRH) and the dopamine antagonist metoclopramide were assessed in 28 patients with hyperprolactinemic amenorrhea and 5 normal cycling women. Lactotrophs were found to be resistant to functional tests, the resistance increasing as the prolactin level went up. Gonadotrophic and thyrotrophic response to functional tests, on the contrary, increased with the progress of hyperprolactinemia. A conclusion is drawn that stable hyperprolactinemia is a result of disturbance in lactotrophic receptor apparatus, for which reason lactotrophs are no longer sensitive to dophamine inhibiting effect on prolactin secretion. SN - 0301-2514 UR - https://www.unboundmedicine.com/medline/citation/1837659/[Disorders_of_the_hypothalamo_hypophyseal_system_as_a_cause_of_infertility_in_hyperprolactinemia]_ L2 - http://www.diseaseinfosearch.org/result/2971 DB - PRIME DP - Unbound Medicine ER -