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Triptans vs other drugs for acute migraine. Are there differences in efficacy? A comment.
Headache. 2008 Apr; 48(4):601-5.H

Abstract

The introduction of triptans in migraine treatment was apparently a revolution. Comparative randomized clinical trials (RCTs) with triptan and other drugs do not give a clear-cut picture. Oral triptans are superior to oral ergotamine most likely because the bioavailability oral of ergotamine is extremely low (<1%). Compared with NSAIDs, in most cases aspirin, triptans were not superior and in several RCTs triptans caused more adverse events than aspirin plus metoclopramide. Guidelines for treatment of migraine should be evidence-based. It is suggested that based on current evidence, effervescent aspirin should be the first-line drug for the treatment of migraine. Aspirin is also much cheaper than the triptans.

Authors+Show Affiliations

Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18377382

Citation

Tfelt-Hansen, Peer. "Triptans Vs Other Drugs for Acute Migraine. Are There Differences in Efficacy? a Comment." Headache, vol. 48, no. 4, 2008, pp. 601-5.
Tfelt-Hansen P. Triptans vs other drugs for acute migraine. Are there differences in efficacy? A comment. Headache. 2008;48(4):601-5.
Tfelt-Hansen, P. (2008). Triptans vs other drugs for acute migraine. Are there differences in efficacy? A comment. Headache, 48(4), 601-5. https://doi.org/10.1111/j.1526-4610.2008.01064.x
Tfelt-Hansen P. Triptans Vs Other Drugs for Acute Migraine. Are There Differences in Efficacy? a Comment. Headache. 2008;48(4):601-5. PubMed PMID: 18377382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triptans vs other drugs for acute migraine. Are there differences in efficacy? A comment. A1 - Tfelt-Hansen,Peer, PY - 2008/4/2/pubmed PY - 2008/6/18/medline PY - 2008/4/2/entrez SP - 601 EP - 5 JF - Headache JO - Headache VL - 48 IS - 4 N2 - The introduction of triptans in migraine treatment was apparently a revolution. Comparative randomized clinical trials (RCTs) with triptan and other drugs do not give a clear-cut picture. Oral triptans are superior to oral ergotamine most likely because the bioavailability oral of ergotamine is extremely low (<1%). Compared with NSAIDs, in most cases aspirin, triptans were not superior and in several RCTs triptans caused more adverse events than aspirin plus metoclopramide. Guidelines for treatment of migraine should be evidence-based. It is suggested that based on current evidence, effervescent aspirin should be the first-line drug for the treatment of migraine. Aspirin is also much cheaper than the triptans. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/18377382/Triptans_vs_other_drugs_for_acute_migraine__Are_there_differences_in_efficacy_A_comment_ DB - PRIME DP - Unbound Medicine ER -