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Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age.
Br J Nutr 2008; 100(5):1104-8BJ

Abstract

The objective was to study the evaluation of serum transferrin receptor (sTfR) for Fe deficiency in women of child-bearing age. Primary screening was performed in 942 women ranging in child-bearing age. Serum ferritin (SF), Zn protoporphyrin (ZPP) and Hb were determined. Then the subjects were divided into four groups: normal, Fe store depletion (IDs), Fe-deficiency erythropoiesis and Fe-deficiency anaemia. sTfR was determined and sTfR/SF (sTfR/logSF and log(sTfR/SF)) was calculated. Changes of sTfR in women of different Fe status were observed. A receiver-operating characteristic (ROC) curve was used to evaluate whether sTfR had proper diagnostic efficacy for functional Fe deficiency. The levels of sTfR increased significantly along with the aggravation of Fe deficiency. Increase of STfR/SF along with the aggravation of Fe deficiency was more significant than that of sTfR. STfR had a significant negative correlation with SF and Hb, while it had a significant positive correlation with ZPP. The ROC curve showed that the diagnostic effective rate of sTfR for Fe deficiency could reach 83 %. At this point, the sensitivity was 79 % and the specificity was 63 %. Log(sTfR/SF) could be considered to have the highest effective ratio in detecting IDs, since it reached 99 %. STfR and sTfR/SF could both reflect body Fe-deficiency status specifically. They could be used as reliable indicators for evaluating Fe status and diagnosing Fe deficiency in women of child-bearing age.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100083 China. xmlin1978@bjmu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18377683

Citation

Lin, Xiao-Ming, et al. "Evaluation of Serum Transferrin Receptor for Iron Deficiency in Women of Child-bearing Age." The British Journal of Nutrition, vol. 100, no. 5, 2008, pp. 1104-8.
Lin XM, Zhang J, Zou ZY, et al. Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age. Br J Nutr. 2008;100(5):1104-8.
Lin, X. M., Zhang, J., Zou, Z. Y., Long, Z., & Tian, W. (2008). Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age. The British Journal of Nutrition, 100(5), pp. 1104-8. doi:10.1017/S0007114508966101.
Lin XM, et al. Evaluation of Serum Transferrin Receptor for Iron Deficiency in Women of Child-bearing Age. Br J Nutr. 2008;100(5):1104-8. PubMed PMID: 18377683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age. AU - Lin,Xiao-Ming, AU - Zhang,Juan, AU - Zou,Zhi-Yong, AU - Long,Zhu, AU - Tian,Wei, Y1 - 2008/04/01/ PY - 2008/4/2/pubmed PY - 2008/11/19/medline PY - 2008/4/2/entrez SP - 1104 EP - 8 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 100 IS - 5 N2 - The objective was to study the evaluation of serum transferrin receptor (sTfR) for Fe deficiency in women of child-bearing age. Primary screening was performed in 942 women ranging in child-bearing age. Serum ferritin (SF), Zn protoporphyrin (ZPP) and Hb were determined. Then the subjects were divided into four groups: normal, Fe store depletion (IDs), Fe-deficiency erythropoiesis and Fe-deficiency anaemia. sTfR was determined and sTfR/SF (sTfR/logSF and log(sTfR/SF)) was calculated. Changes of sTfR in women of different Fe status were observed. A receiver-operating characteristic (ROC) curve was used to evaluate whether sTfR had proper diagnostic efficacy for functional Fe deficiency. The levels of sTfR increased significantly along with the aggravation of Fe deficiency. Increase of STfR/SF along with the aggravation of Fe deficiency was more significant than that of sTfR. STfR had a significant negative correlation with SF and Hb, while it had a significant positive correlation with ZPP. The ROC curve showed that the diagnostic effective rate of sTfR for Fe deficiency could reach 83 %. At this point, the sensitivity was 79 % and the specificity was 63 %. Log(sTfR/SF) could be considered to have the highest effective ratio in detecting IDs, since it reached 99 %. STfR and sTfR/SF could both reflect body Fe-deficiency status specifically. They could be used as reliable indicators for evaluating Fe status and diagnosing Fe deficiency in women of child-bearing age. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18377683/Evaluation_of_serum_transferrin_receptor_for_iron_deficiency_in_women_of_child_bearing_age_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508966101/type/journal_article DB - PRIME DP - Unbound Medicine ER -