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Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.
Br J Nutr. 2008 Dec; 100(6):1179-82.BJ

Abstract

In the present study, eighty-four breast cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d. A significant increase in poly(ADP-ribose) polymerase levels and disappearance of RASSF1A DNA methylation patterns were found in patients treated with supplement therapy along with tamoxifen compared to untreated breast cancer patients and tamoxifen alone-treated patients. An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment.

Authors+Show Affiliations

Department of Medical Biochemistry, DR. A.L.M. Post-Graduate, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18377693

Citation

Premkumar, Vummidi Giridhar, et al. "Co-enzyme Q10, Riboflavin and Niacin Supplementation On Alteration of DNA Repair Enzyme and DNA Methylation in Breast Cancer Patients Undergoing Tamoxifen Therapy." The British Journal of Nutrition, vol. 100, no. 6, 2008, pp. 1179-82.
Premkumar VG, Yuvaraj S, Shanthi P, et al. Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. Br J Nutr. 2008;100(6):1179-82.
Premkumar, V. G., Yuvaraj, S., Shanthi, P., & Sachdanandam, P. (2008). Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. The British Journal of Nutrition, 100(6), 1179-82. https://doi.org/10.1017/S0007114508968276
Premkumar VG, et al. Co-enzyme Q10, Riboflavin and Niacin Supplementation On Alteration of DNA Repair Enzyme and DNA Methylation in Breast Cancer Patients Undergoing Tamoxifen Therapy. Br J Nutr. 2008;100(6):1179-82. PubMed PMID: 18377693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. AU - Premkumar,Vummidi Giridhar, AU - Yuvaraj,Srinivasan, AU - Shanthi,Palanivel, AU - Sachdanandam,Panchanatham, PY - 2008/4/2/pubmed PY - 2008/12/31/medline PY - 2008/4/2/entrez SP - 1179 EP - 82 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 100 IS - 6 N2 - In the present study, eighty-four breast cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d. A significant increase in poly(ADP-ribose) polymerase levels and disappearance of RASSF1A DNA methylation patterns were found in patients treated with supplement therapy along with tamoxifen compared to untreated breast cancer patients and tamoxifen alone-treated patients. An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18377693/Co_enzyme_Q10_riboflavin_and_niacin_supplementation_on_alteration_of_DNA_repair_enzyme_and_DNA_methylation_in_breast_cancer_patients_undergoing_tamoxifen_therapy_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508968276/type/journal_article DB - PRIME DP - Unbound Medicine ER -