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Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease.
Neurosci Lett 2008; 436(2):153-7NL

Abstract

Cerebrospinal fluid (CSF) may be of valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects. In this report, we applied proteomics approaches to analyze 60 CSF samples derived from patients with neurodegenerative diseases such as MCI and AD. We classified patients by three groups: normal controls without cognitive dysfunction, MCI and AD. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia. We demonstrated a gradual decrease or absent of plasma retinol-binding protein (RBP) and haptoglobin precursor allele 1 in CSF from patients with MCI and AD compared to the age-matched normal subjects. Moreover, expression levels of both RBP and haptoglobin precursor allele 1 were observed to be very high in age-matched normal subjects. In contrast, the RBP and haptoglobin precursor allele 1 were much decreased in the MCI group; those expressions were more weak or absent in AD group, and correlated with disease severity and progression. These findings suggest that the CSF levels of both RBP and haptoglobin precursor allele 1 may be candidate biomarkers for the progression of normal to MCI to AD.

Authors+Show Affiliations

Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul 137-040, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18378077

Citation

Jung, Sang Min, et al. "Both Plasma Retinol-binding Protein and Haptoglobin Precursor Allele 1 in CSF: Candidate Biomarkers for the Progression of Normal to Mild Cognitive Impairment to Alzheimer's Disease." Neuroscience Letters, vol. 436, no. 2, 2008, pp. 153-7.
Jung SM, Lee K, Lee JW, et al. Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease. Neurosci Lett. 2008;436(2):153-7.
Jung, S. M., Lee, K., Lee, J. W., Namkoong, H., Kim, H. K., Kim, S., ... Kim, J. W. (2008). Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease. Neuroscience Letters, 436(2), pp. 153-7. doi:10.1016/j.neulet.2008.03.010.
Jung SM, et al. Both Plasma Retinol-binding Protein and Haptoglobin Precursor Allele 1 in CSF: Candidate Biomarkers for the Progression of Normal to Mild Cognitive Impairment to Alzheimer's Disease. Neurosci Lett. 2008 May 9;436(2):153-7. PubMed PMID: 18378077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease. AU - Jung,Sang Min, AU - Lee,Kibeom, AU - Lee,Joung Wook, AU - Namkoong,Hong, AU - Kim,Hyun Kee, AU - Kim,Sanghee, AU - Na,Hae Ri, AU - Ha,Seon-Ah, AU - Kim,Jae-Ryong, AU - Ko,Jesang, AU - Kim,Jin Woo, Y1 - 2008/03/18/ PY - 2007/11/27/received PY - 2008/03/04/revised PY - 2008/03/05/accepted PY - 2008/4/2/pubmed PY - 2008/8/14/medline PY - 2008/4/2/entrez SP - 153 EP - 7 JF - Neuroscience letters JO - Neurosci. Lett. VL - 436 IS - 2 N2 - Cerebrospinal fluid (CSF) may be of valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects. In this report, we applied proteomics approaches to analyze 60 CSF samples derived from patients with neurodegenerative diseases such as MCI and AD. We classified patients by three groups: normal controls without cognitive dysfunction, MCI and AD. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia. We demonstrated a gradual decrease or absent of plasma retinol-binding protein (RBP) and haptoglobin precursor allele 1 in CSF from patients with MCI and AD compared to the age-matched normal subjects. Moreover, expression levels of both RBP and haptoglobin precursor allele 1 were observed to be very high in age-matched normal subjects. In contrast, the RBP and haptoglobin precursor allele 1 were much decreased in the MCI group; those expressions were more weak or absent in AD group, and correlated with disease severity and progression. These findings suggest that the CSF levels of both RBP and haptoglobin precursor allele 1 may be candidate biomarkers for the progression of normal to MCI to AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/18378077/Both_plasma_retinol_binding_protein_and_haptoglobin_precursor_allele_1_in_CSF:_candidate_biomarkers_for_the_progression_of_normal_to_mild_cognitive_impairment_to_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)00307-8 DB - PRIME DP - Unbound Medicine ER -