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A test of alcohol dose effects on multiple behavioral measures of impulsivity.
Drug Alcohol Depend. 2008 Jul 01; 96(1-2):111-20.DA

Abstract

BACKGROUND

Acute alcohol administration affects impulsive behavior, although these effects vary as a function of alcohol dose, assessment instrument, and time of measurement following administration.

METHODS

We concurrently examined the dose-dependent effects of alcohol on three distinct types of impulsivity tasks (continuous performance [IMT], stop-signal [GoStop], and delay-discounting [SKIP] tasks). Ninety healthy alcohol drinkers were assigned to one of the three task groups (n=30 each), each group experienced placebo, 0.2, 0.4, 0.6, and 0.8 g/kg alcohol doses across 5 experimental days, and task performance was assessed at 0.5h before and 0.25, 1.0, and 2.0 h after alcohol administration. We hypothesized that impulsive responding on all tasks would be increased by acute alcohol administration both across time and during the peak BrAC, but the magnitude would depend on the task being tested. Analyses included the time course and the peak BrAC effects. Task comparisons of peak behavioral changes following each dose are illustrated using standardized scores.

RESULTS

While alcohol consumption increased impulsive responding during all three tasks to some extent, our hypothesis was only partially supported. During the IMT, the 0.6 and 0.8 g/kg doses produced increased impulsive responding across time and at the peak BrAC. However, during the GoStop and SKIP, impulsivity increased across time regardless of the alcohol dose size, with no differences in impulsive responding among dose conditions at peak BrAC.

CONCLUSIONS

This study demonstrated alcohol-induced changes in impulsivity are not uniformly affected by alcohol. These data, in conjunction with previous studies, further support that impulsivity is not a unitary construct.

Authors+Show Affiliations

Neurobehavioral Research Laboratory and Clinic, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. doughertyd@uthscsa.edu <doughertyd@uthscsa.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18378098

Citation

Dougherty, Donald M., et al. "A Test of Alcohol Dose Effects On Multiple Behavioral Measures of Impulsivity." Drug and Alcohol Dependence, vol. 96, no. 1-2, 2008, pp. 111-20.
Dougherty DM, Marsh-Richard DM, Hatzis ES, et al. A test of alcohol dose effects on multiple behavioral measures of impulsivity. Drug Alcohol Depend. 2008;96(1-2):111-20.
Dougherty, D. M., Marsh-Richard, D. M., Hatzis, E. S., Nouvion, S. O., & Mathias, C. W. (2008). A test of alcohol dose effects on multiple behavioral measures of impulsivity. Drug and Alcohol Dependence, 96(1-2), 111-20. https://doi.org/10.1016/j.drugalcdep.2008.02.002
Dougherty DM, et al. A Test of Alcohol Dose Effects On Multiple Behavioral Measures of Impulsivity. Drug Alcohol Depend. 2008 Jul 1;96(1-2):111-20. PubMed PMID: 18378098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A test of alcohol dose effects on multiple behavioral measures of impulsivity. AU - Dougherty,Donald M, AU - Marsh-Richard,Dawn M, AU - Hatzis,Erin S, AU - Nouvion,Sylvain O, AU - Mathias,Charles W, Y1 - 2008/04/02/ PY - 2007/04/27/received PY - 2008/02/12/revised PY - 2008/02/13/accepted PY - 2008/4/2/pubmed PY - 2008/9/13/medline PY - 2008/4/2/entrez SP - 111 EP - 20 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 96 IS - 1-2 N2 - BACKGROUND: Acute alcohol administration affects impulsive behavior, although these effects vary as a function of alcohol dose, assessment instrument, and time of measurement following administration. METHODS: We concurrently examined the dose-dependent effects of alcohol on three distinct types of impulsivity tasks (continuous performance [IMT], stop-signal [GoStop], and delay-discounting [SKIP] tasks). Ninety healthy alcohol drinkers were assigned to one of the three task groups (n=30 each), each group experienced placebo, 0.2, 0.4, 0.6, and 0.8 g/kg alcohol doses across 5 experimental days, and task performance was assessed at 0.5h before and 0.25, 1.0, and 2.0 h after alcohol administration. We hypothesized that impulsive responding on all tasks would be increased by acute alcohol administration both across time and during the peak BrAC, but the magnitude would depend on the task being tested. Analyses included the time course and the peak BrAC effects. Task comparisons of peak behavioral changes following each dose are illustrated using standardized scores. RESULTS: While alcohol consumption increased impulsive responding during all three tasks to some extent, our hypothesis was only partially supported. During the IMT, the 0.6 and 0.8 g/kg doses produced increased impulsive responding across time and at the peak BrAC. However, during the GoStop and SKIP, impulsivity increased across time regardless of the alcohol dose size, with no differences in impulsive responding among dose conditions at peak BrAC. CONCLUSIONS: This study demonstrated alcohol-induced changes in impulsivity are not uniformly affected by alcohol. These data, in conjunction with previous studies, further support that impulsivity is not a unitary construct. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/18378098/A_test_of_alcohol_dose_effects_on_multiple_behavioral_measures_of_impulsivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(08)00070-7 DB - PRIME DP - Unbound Medicine ER -