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Fatty acids, lipid metabolism and Alzheimer pathology.
Eur J Pharmacol 2008; 585(1):176-96EJ

Abstract

Alzheimer's disease is the most common form of dementia in the elderly. The cause of Alzheimer's disease is still unknown and there is no cure for the disease yet despite 100 years of extensive research. Cardiovascular risk factors such as high serum cholesterol, presence of the Apolipoprotein epsilon4 (APOE epsilon4) allele and hypertension, play important roles in the development of Alzheimer's disease. We postulate that a combination of diet, lifestyle, vascular, genetic, and amyloid related factors, which enhance each other's contribution in the onset and course of Alzheimer's disease, will be more likely the cause of the disease instead of one sole mechanism. The possibility that the risk for Alzheimer's disease can be reduced by diet or lifestyle is of great importance and suggests a preventative treatment in Alzheimer's disease. Because of the great importance of lipid diets and metabolism in preventative treatment against both Alzheimer's disease and cardiovascular disease, long-chain polyunsaturated fatty acids from fish oil, ApoE genotype and cholesterol metabolism in correlation with Alzheimer's disease will be reviewed.

Authors+Show Affiliations

Department of Anatomy and Department of Cognitive Neuroscience, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Room M245/0.24 PO Box 9101, 6500 HB Nijmegen, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18378224

Citation

Hooijmans, Carlijn R., and Amanda J. Kiliaan. "Fatty Acids, Lipid Metabolism and Alzheimer Pathology." European Journal of Pharmacology, vol. 585, no. 1, 2008, pp. 176-96.
Hooijmans CR, Kiliaan AJ. Fatty acids, lipid metabolism and Alzheimer pathology. Eur J Pharmacol. 2008;585(1):176-96.
Hooijmans, C. R., & Kiliaan, A. J. (2008). Fatty acids, lipid metabolism and Alzheimer pathology. European Journal of Pharmacology, 585(1), pp. 176-96. doi:10.1016/j.ejphar.2007.11.081.
Hooijmans CR, Kiliaan AJ. Fatty Acids, Lipid Metabolism and Alzheimer Pathology. Eur J Pharmacol. 2008 May 6;585(1):176-96. PubMed PMID: 18378224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acids, lipid metabolism and Alzheimer pathology. AU - Hooijmans,Carlijn R, AU - Kiliaan,Amanda J, Y1 - 2008/02/29/ PY - 2007/08/15/received PY - 2007/09/11/revised PY - 2007/11/15/accepted PY - 2008/4/2/pubmed PY - 2008/11/1/medline PY - 2008/4/2/entrez SP - 176 EP - 96 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 585 IS - 1 N2 - Alzheimer's disease is the most common form of dementia in the elderly. The cause of Alzheimer's disease is still unknown and there is no cure for the disease yet despite 100 years of extensive research. Cardiovascular risk factors such as high serum cholesterol, presence of the Apolipoprotein epsilon4 (APOE epsilon4) allele and hypertension, play important roles in the development of Alzheimer's disease. We postulate that a combination of diet, lifestyle, vascular, genetic, and amyloid related factors, which enhance each other's contribution in the onset and course of Alzheimer's disease, will be more likely the cause of the disease instead of one sole mechanism. The possibility that the risk for Alzheimer's disease can be reduced by diet or lifestyle is of great importance and suggests a preventative treatment in Alzheimer's disease. Because of the great importance of lipid diets and metabolism in preventative treatment against both Alzheimer's disease and cardiovascular disease, long-chain polyunsaturated fatty acids from fish oil, ApoE genotype and cholesterol metabolism in correlation with Alzheimer's disease will be reviewed. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18378224/Fatty_acids_lipid_metabolism_and_Alzheimer_pathology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00229-X DB - PRIME DP - Unbound Medicine ER -