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Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model.
Exp Eye Res. 2008 May; 86(5):770-82.EE

Abstract

Monkey eyes are useful for ophthalmologic research into eye diseases because their histological and functional properties are very similar to those of humans. The monkey laser-induced high intraocular pressure (IOP) model is a common model for ophthalmologic research, especially into glaucoma. Although several studies using this model have focused on changes in visual field, retinal ganglion cells (RGC), and lateral geniculate nucleus (LGN), clear relationships among these changes in one and the same monkey have not been established. We therefore examined visual field changes, RGC and LGN numbers, and glial fibrous acidic protein (GFAP) immunohistochemistry in the LGN in each of two monkeys. Visual field sensitivity, RGC number, and neuronal density of LGN were all decreased by high IOP. The relationship between loss of RGC and decrease in visual field sensitivity depended on the eccentricity from the fovea. Moreover, LGN immunohistochemistry revealed greater increases in GFAP expression in the layers receiving a neuronal input from the high IOP eye than in those receiving a neuronal input from the contralateral untreated eye. From these results, we suggest that glaucoma may lead to changes in glial function not only in the retina, but also in the visual pathway, and that such central nervous system changes may be a hallmark of neuropathy in glaucoma, as in other neurodegenerative diseases.

Authors+Show Affiliations

Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, 41-2 Kanrin, Inuyama, Aichi 484-8506, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18378230

Citation

Sasaoka, Masaaki, et al. "Changes in Visual Fields and Lateral Geniculate Nucleus in Monkey Laser-induced High Intraocular Pressure Model." Experimental Eye Research, vol. 86, no. 5, 2008, pp. 770-82.
Sasaoka M, Nakamura K, Shimazawa M, et al. Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. Exp Eye Res. 2008;86(5):770-82.
Sasaoka, M., Nakamura, K., Shimazawa, M., Ito, Y., Araie, M., & Hara, H. (2008). Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. Experimental Eye Research, 86(5), 770-82. https://doi.org/10.1016/j.exer.2008.02.004
Sasaoka M, et al. Changes in Visual Fields and Lateral Geniculate Nucleus in Monkey Laser-induced High Intraocular Pressure Model. Exp Eye Res. 2008;86(5):770-82. PubMed PMID: 18378230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. AU - Sasaoka,Masaaki, AU - Nakamura,Katsuki, AU - Shimazawa,Masamitsu, AU - Ito,Yasushi, AU - Araie,Makoto, AU - Hara,Hideaki, Y1 - 2008/02/26/ PY - 2007/11/26/received PY - 2008/02/06/revised PY - 2008/02/15/accepted PY - 2008/4/2/pubmed PY - 2008/9/16/medline PY - 2008/4/2/entrez SP - 770 EP - 82 JF - Experimental eye research JO - Exp Eye Res VL - 86 IS - 5 N2 - Monkey eyes are useful for ophthalmologic research into eye diseases because their histological and functional properties are very similar to those of humans. The monkey laser-induced high intraocular pressure (IOP) model is a common model for ophthalmologic research, especially into glaucoma. Although several studies using this model have focused on changes in visual field, retinal ganglion cells (RGC), and lateral geniculate nucleus (LGN), clear relationships among these changes in one and the same monkey have not been established. We therefore examined visual field changes, RGC and LGN numbers, and glial fibrous acidic protein (GFAP) immunohistochemistry in the LGN in each of two monkeys. Visual field sensitivity, RGC number, and neuronal density of LGN were all decreased by high IOP. The relationship between loss of RGC and decrease in visual field sensitivity depended on the eccentricity from the fovea. Moreover, LGN immunohistochemistry revealed greater increases in GFAP expression in the layers receiving a neuronal input from the high IOP eye than in those receiving a neuronal input from the contralateral untreated eye. From these results, we suggest that glaucoma may lead to changes in glial function not only in the retina, but also in the visual pathway, and that such central nervous system changes may be a hallmark of neuropathy in glaucoma, as in other neurodegenerative diseases. SN - 0014-4835 UR - https://www.unboundmedicine.com/medline/citation/18378230/Changes_in_visual_fields_and_lateral_geniculate_nucleus_in_monkey_laser_induced_high_intraocular_pressure_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4835(08)00063-8 DB - PRIME DP - Unbound Medicine ER -