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Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome.
Hum Reprod 2008; 23(7):1602-6HR

Abstract

BACKGROUND

Carnitine plays essential roles in energy production, oxidative stress and glucose metabolism. This study was planned to determine serum total L-carnitine levels in non-obese women with polycystic ovary syndrome (PCOS).

METHODS

There were 27 non-obese women with PCOS and 30 healthy, age- and body mass index (BMI) matched controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin and other hormones (gonadotrophins, androgens) and total L-carnitine levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance.

RESULTS

The women with PCOS had significantly higher serum dehydroepiandrosterone sulfate, total testosterone, free androgen index (FAI), luteinizing hormone (LH), low-density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, fasting insulin levels and HOMA-IR measurement and LH/FSH ratios than healthy women. However, total L-carnitine and sex hormone-binding globulin (SHBG) levels were significantly lower in women with PCOS. L-Carnitine level was negatively correlated with FAI, but positively correlated with SHBG. Multiple regression analysis revealed that SHBG was a strong predictor of serum total L-carnitine level.

CONCLUSIONS

Decreased total L-carnitine levels may be associated with hyperandrogenism and/or insulin resistance in non-obese women with PCOS. Long-term studies are needed to evaluate carnitine metabolism in PCOS, especially with regard to the molecular basis.

Authors+Show Affiliations

Department of Internal Medicine, Division of Endocrinology and Metabolism, Pamukkale University, School of Medicine, 20100 Denizli, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18378560

Citation

Fenkci, Semin Melahat, et al. "Serum Total L-carnitine Levels in Non-obese Women With Polycystic Ovary Syndrome." Human Reproduction (Oxford, England), vol. 23, no. 7, 2008, pp. 1602-6.
Fenkci SM, Fenkci V, Oztekin O, et al. Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. Hum Reprod. 2008;23(7):1602-6.
Fenkci, S. M., Fenkci, V., Oztekin, O., Rota, S., & Karagenc, N. (2008). Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. Human Reproduction (Oxford, England), 23(7), pp. 1602-6. doi:10.1093/humrep/den109.
Fenkci SM, et al. Serum Total L-carnitine Levels in Non-obese Women With Polycystic Ovary Syndrome. Hum Reprod. 2008;23(7):1602-6. PubMed PMID: 18378560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. AU - Fenkci,Semin Melahat, AU - Fenkci,Veysel, AU - Oztekin,Ozer, AU - Rota,Simin, AU - Karagenc,Nedim, Y1 - 2008/03/31/ PY - 2008/4/2/pubmed PY - 2008/7/23/medline PY - 2008/4/2/entrez SP - 1602 EP - 6 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 23 IS - 7 N2 - BACKGROUND: Carnitine plays essential roles in energy production, oxidative stress and glucose metabolism. This study was planned to determine serum total L-carnitine levels in non-obese women with polycystic ovary syndrome (PCOS). METHODS: There were 27 non-obese women with PCOS and 30 healthy, age- and body mass index (BMI) matched controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin and other hormones (gonadotrophins, androgens) and total L-carnitine levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. RESULTS: The women with PCOS had significantly higher serum dehydroepiandrosterone sulfate, total testosterone, free androgen index (FAI), luteinizing hormone (LH), low-density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, fasting insulin levels and HOMA-IR measurement and LH/FSH ratios than healthy women. However, total L-carnitine and sex hormone-binding globulin (SHBG) levels were significantly lower in women with PCOS. L-Carnitine level was negatively correlated with FAI, but positively correlated with SHBG. Multiple regression analysis revealed that SHBG was a strong predictor of serum total L-carnitine level. CONCLUSIONS: Decreased total L-carnitine levels may be associated with hyperandrogenism and/or insulin resistance in non-obese women with PCOS. Long-term studies are needed to evaluate carnitine metabolism in PCOS, especially with regard to the molecular basis. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/18378560/Serum_total_L_carnitine_levels_in_non_obese_women_with_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/den109 DB - PRIME DP - Unbound Medicine ER -