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Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression.
Br J Psychiatry. 2008 Apr; 192(4):268-74.BJ

Abstract

BACKGROUND

The role of folate, vitamin B(12) and homocysteine levels in depression is not clear.

AIMS

To investigate cross-sectional and prospective associations between folate, B(12) and homocysteine levels and late-life depression.

METHOD

A total of 732 Korean people aged 65 years or over were evaluated at baseline. Of the 631 persons who were not depressed, 521 (83%) were followed over a period of 2-3 years and incident depression was ascertained with the Geriatric Mental State schedule. Serum folate, serum vitamin B(12) and plasma homocysteine levels were assayed at both baseline and follow-up.

RESULTS

Lower levels of folate and vitamin B(12) and higher homocysteine levels at baseline were associated with a higher risk of incident depression at follow-up. Incident depression was associated with a decline in vitamin B(12) and an increase in homocysteine levels over the follow-up period.

CONCLUSIONS

Lower folate, lower vitamin B(12) and raised homocysteine levels may be risk factors for late-life depression.

Authors+Show Affiliations

Department of Psychiatry and Depression Clinical Research Centre, Chonnam National University Medical School, Kwangju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18378986

Citation

Kim, Jae-Min, et al. "Predictive Value of Folate, Vitamin B12 and Homocysteine Levels in Late-life Depression." The British Journal of Psychiatry : the Journal of Mental Science, vol. 192, no. 4, 2008, pp. 268-74.
Kim JM, Stewart R, Kim SW, et al. Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Br J Psychiatry. 2008;192(4):268-74.
Kim, J. M., Stewart, R., Kim, S. W., Yang, S. J., Shin, I. S., & Yoon, J. S. (2008). Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. The British Journal of Psychiatry : the Journal of Mental Science, 192(4), 268-74. https://doi.org/10.1192/bjp.bp.107.039511
Kim JM, et al. Predictive Value of Folate, Vitamin B12 and Homocysteine Levels in Late-life Depression. Br J Psychiatry. 2008;192(4):268-74. PubMed PMID: 18378986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. AU - Kim,Jae-Min, AU - Stewart,Robert, AU - Kim,Sung-Wan, AU - Yang,Su-Jin, AU - Shin,Il-Seon, AU - Yoon,Jin-Sang, PY - 2008/4/2/pubmed PY - 2008/8/8/medline PY - 2008/4/2/entrez SP - 268 EP - 74 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 192 IS - 4 N2 - BACKGROUND: The role of folate, vitamin B(12) and homocysteine levels in depression is not clear. AIMS: To investigate cross-sectional and prospective associations between folate, B(12) and homocysteine levels and late-life depression. METHOD: A total of 732 Korean people aged 65 years or over were evaluated at baseline. Of the 631 persons who were not depressed, 521 (83%) were followed over a period of 2-3 years and incident depression was ascertained with the Geriatric Mental State schedule. Serum folate, serum vitamin B(12) and plasma homocysteine levels were assayed at both baseline and follow-up. RESULTS: Lower levels of folate and vitamin B(12) and higher homocysteine levels at baseline were associated with a higher risk of incident depression at follow-up. Incident depression was associated with a decline in vitamin B(12) and an increase in homocysteine levels over the follow-up period. CONCLUSIONS: Lower folate, lower vitamin B(12) and raised homocysteine levels may be risk factors for late-life depression. SN - 0007-1250 UR - https://www.unboundmedicine.com/medline/citation/18378986/Predictive_value_of_folate_vitamin_B12_and_homocysteine_levels_in_late_life_depression_ L2 - https://www.cambridge.org/core/product/identifier/S0007125000234545/type/journal_article DB - PRIME DP - Unbound Medicine ER -