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Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems.
Chem Pharm Bull (Tokyo). 2008 Apr; 56(4):569-74.CP

Abstract

To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Kyungsan, Kyungbuk, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18379109

Citation

Newa, Madhuri, et al. "Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems." Chemical & Pharmaceutical Bulletin, vol. 56, no. 4, 2008, pp. 569-74.
Newa M, Bhandari KH, Kim JO, et al. Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems. Chem Pharm Bull (Tokyo). 2008;56(4):569-74.
Newa, M., Bhandari, K. H., Kim, J. O., Im, J. S., Kim, J. A., Yoo, B. K., Woo, J. S., Choi, H. G., & Yong, C. S. (2008). Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems. Chemical & Pharmaceutical Bulletin, 56(4), 569-74.
Newa M, et al. Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems. Chem Pharm Bull (Tokyo). 2008;56(4):569-74. PubMed PMID: 18379109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems. AU - Newa,Madhuri, AU - Bhandari,Krishna Hari, AU - Kim,Jong Oh, AU - Im,Jong Seob, AU - Kim,Jung Ae, AU - Yoo,Bong Kyu, AU - Woo,Jong Soo, AU - Choi,Han Gon, AU - Yong,Chul Soon, PY - 2008/4/2/pubmed PY - 2008/6/10/medline PY - 2008/4/2/entrez SP - 569 EP - 74 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 56 IS - 4 N2 - To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen. SN - 0009-2363 UR - https://www.unboundmedicine.com/medline/citation/18379109/Enhancement_of_solubility_dissolution_and_bioavailability_of_ibuprofen_in_solid_dispersion_systems_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/cpb/56.569?from=PubMed DB - PRIME DP - Unbound Medicine ER -