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Effects of exercise training and montelukast in children with mild asthma.
Med Sci Sports Exerc. 2008 Mar; 40(3):405-12.MS

Abstract

PURPOSE

Data from the general population suggest that habitual exercise decreases bronchial responsiveness, but the possible role of exercise in asthmatics is undefined. The leukotriene receptor antagonist montelukast decreases bronchial responsiveness and exercise-induced symptoms in asthmatic children. This randomized study in children with mild asthma evaluated the combined effects of aerobic training for 12 wk and montelukast or placebo on bronchial responsiveness (BHR) to methacholine, exercise-induced bronchoconstriction (EIB), inflammatory markers in exhaled breath condensate (EBC), and asthma exacerbations.

METHODS

Fifty children (mean age +/- SD: 10.2 +/- 2.4 yr) with mild stable asthma were randomly assigned to placebo (N = 25) or montelukast (N = 25). Before and after training, we assessed BHR and EIB and markers of airway inflammation-that is, exhaled nitric oxide (eNO), pH, and cysteinyl-leukotriene concentration-in EBC.

RESULTS

Training increased maximal workload and peak minute ventilation. After training, the methacholine dose causing a 20% fall in FEV1 (PD20) increased in both groups. A decreased slope of FEV1 decline at increasing methacholine dose was found only in montelukast-treated children. EIB prevalence halved after training in both groups (EIB + children, placebo group: 10 pretraining, 4 posttraining; EIB + children, montelukast group: 8 pretraining, 5 posttraining; P < 0.05 by chi on all children). Resting eNO was unaffected, whereas the pH of EBC decreased after training in both groups. Cysteinyl-leukotriene concentrations were low in most children at both times. During training, montelukast-treated children showed fewer asthma exacerbations compared with the same period of the previous year.

CONCLUSIONS

In children with mild stable asthma, exercise training decreased bronchial responsiveness to methacholine. Montelukast also decreased bronchial reactivity (FEV1 slope) and protected against exacerbations, suggesting a beneficial synergistic action of these two interventions in mild asthma.

Authors+Show Affiliations

Department of Medicine, Pneumology, Physiology and Nutrition, University of Palermo, Italy. marisa@ibim.cnr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18379200

Citation

Bonsignore, Maria R., et al. "Effects of Exercise Training and Montelukast in Children With Mild Asthma." Medicine and Science in Sports and Exercise, vol. 40, no. 3, 2008, pp. 405-12.
Bonsignore MR, La Grutta S, Cibella F, et al. Effects of exercise training and montelukast in children with mild asthma. Med Sci Sports Exerc. 2008;40(3):405-12.
Bonsignore, M. R., La Grutta, S., Cibella, F., Scichilone, N., Cuttitta, G., Interrante, A., Marchese, M., Veca, M., Virzi', M., Bonanno, A., Profita, M., & Morici, G. (2008). Effects of exercise training and montelukast in children with mild asthma. Medicine and Science in Sports and Exercise, 40(3), 405-12. https://doi.org/10.1249/MSS.0b013e31815d9670
Bonsignore MR, et al. Effects of Exercise Training and Montelukast in Children With Mild Asthma. Med Sci Sports Exerc. 2008;40(3):405-12. PubMed PMID: 18379200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of exercise training and montelukast in children with mild asthma. AU - Bonsignore,Maria R, AU - La Grutta,Stefania, AU - Cibella,Fabio, AU - Scichilone,Nicola, AU - Cuttitta,Giuseppina, AU - Interrante,Amelia, AU - Marchese,Margherita, AU - Veca,Mario, AU - Virzi',Marco, AU - Bonanno,Anna, AU - Profita,Mirella, AU - Morici,Giuseppe, PY - 2008/4/2/pubmed PY - 2008/5/23/medline PY - 2008/4/2/entrez SP - 405 EP - 12 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 40 IS - 3 N2 - PURPOSE: Data from the general population suggest that habitual exercise decreases bronchial responsiveness, but the possible role of exercise in asthmatics is undefined. The leukotriene receptor antagonist montelukast decreases bronchial responsiveness and exercise-induced symptoms in asthmatic children. This randomized study in children with mild asthma evaluated the combined effects of aerobic training for 12 wk and montelukast or placebo on bronchial responsiveness (BHR) to methacholine, exercise-induced bronchoconstriction (EIB), inflammatory markers in exhaled breath condensate (EBC), and asthma exacerbations. METHODS: Fifty children (mean age +/- SD: 10.2 +/- 2.4 yr) with mild stable asthma were randomly assigned to placebo (N = 25) or montelukast (N = 25). Before and after training, we assessed BHR and EIB and markers of airway inflammation-that is, exhaled nitric oxide (eNO), pH, and cysteinyl-leukotriene concentration-in EBC. RESULTS: Training increased maximal workload and peak minute ventilation. After training, the methacholine dose causing a 20% fall in FEV1 (PD20) increased in both groups. A decreased slope of FEV1 decline at increasing methacholine dose was found only in montelukast-treated children. EIB prevalence halved after training in both groups (EIB + children, placebo group: 10 pretraining, 4 posttraining; EIB + children, montelukast group: 8 pretraining, 5 posttraining; P < 0.05 by chi on all children). Resting eNO was unaffected, whereas the pH of EBC decreased after training in both groups. Cysteinyl-leukotriene concentrations were low in most children at both times. During training, montelukast-treated children showed fewer asthma exacerbations compared with the same period of the previous year. CONCLUSIONS: In children with mild stable asthma, exercise training decreased bronchial responsiveness to methacholine. Montelukast also decreased bronchial reactivity (FEV1 slope) and protected against exacerbations, suggesting a beneficial synergistic action of these two interventions in mild asthma. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/18379200/Effects_of_exercise_training_and_montelukast_in_children_with_mild_asthma_ L2 - https://doi.org/10.1249/MSS.0b013e31815d9670 DB - PRIME DP - Unbound Medicine ER -