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Prevention of disuse muscular weakness by restriction of blood flow.
Med Sci Sports Exerc. 2008 Mar; 40(3):529-34.MS

Abstract

PURPOSE

The aim of the present study was to compare the effects of periodic restriction of blood flow to lower extremities with those of isometric exercise on disuse muscular atrophy and weakness induced by immobilization and unloading.

METHODS

The left ankle of each of 15 healthy males was immobilized for 2 wk using cast, and subjects were instructed to walk using crutches with non-weight bearing during this period. Subjects were divided into three groups: a restriction of blood flow (RBF) group (application of external compressive force of 200 mm Hg for 5 min followed by 3 min of rest, repeated five times in a single session, two sessions per day for 14 d); an isometric training (IMT) group (20 "exercises" of 5-s isometric contraction of the knee extensor, flexor, and ankle plantar flexor muscles followed by rest, twice a day, daily for 2 wk); and a control (CON) group (no intervention). We measured changes in muscle strength, thigh/leg circumferences, and serum growth hormone levels.

RESULTS

Immobilization/unloading resulted in significant decreases in muscle strength of knee extensor and flexor muscles (P < 0.01 and < 0.05, respectively) and thigh and leg circumferences (P < 0.05, each) in the CON group, and significant decreases in muscle strength of the knee flexor muscles, ankle plantar flexor muscles, and leg circumference (P < 0.05) in the IMT group. RBF protected against these changes in muscle strength and thigh/leg circumference (P < 0.01 and < 0.05, respectively). No changes in serum growth hormone levels were noted.

CONCLUSION

Our results indicate that repetitive restriction of blood flow to the lower extremity prevents disuse muscular weakness.

Authors+Show Affiliations

Department of Sports Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan. akubota@med.juntendo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18379217

Citation

Kubota, Atsushi, et al. "Prevention of Disuse Muscular Weakness By Restriction of Blood Flow." Medicine and Science in Sports and Exercise, vol. 40, no. 3, 2008, pp. 529-34.
Kubota A, Sakuraba K, Sawaki K, et al. Prevention of disuse muscular weakness by restriction of blood flow. Med Sci Sports Exerc. 2008;40(3):529-34.
Kubota, A., Sakuraba, K., Sawaki, K., Sumide, T., & Tamura, Y. (2008). Prevention of disuse muscular weakness by restriction of blood flow. Medicine and Science in Sports and Exercise, 40(3), 529-34. https://doi.org/10.1249/MSS.0b013e31815ddac6
Kubota A, et al. Prevention of Disuse Muscular Weakness By Restriction of Blood Flow. Med Sci Sports Exerc. 2008;40(3):529-34. PubMed PMID: 18379217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of disuse muscular weakness by restriction of blood flow. AU - Kubota,Atsushi, AU - Sakuraba,Keishoku, AU - Sawaki,Keisuke, AU - Sumide,Takahiro, AU - Tamura,Yoshifumi, PY - 2008/4/2/pubmed PY - 2008/5/23/medline PY - 2008/4/2/entrez SP - 529 EP - 34 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 40 IS - 3 N2 - PURPOSE: The aim of the present study was to compare the effects of periodic restriction of blood flow to lower extremities with those of isometric exercise on disuse muscular atrophy and weakness induced by immobilization and unloading. METHODS: The left ankle of each of 15 healthy males was immobilized for 2 wk using cast, and subjects were instructed to walk using crutches with non-weight bearing during this period. Subjects were divided into three groups: a restriction of blood flow (RBF) group (application of external compressive force of 200 mm Hg for 5 min followed by 3 min of rest, repeated five times in a single session, two sessions per day for 14 d); an isometric training (IMT) group (20 "exercises" of 5-s isometric contraction of the knee extensor, flexor, and ankle plantar flexor muscles followed by rest, twice a day, daily for 2 wk); and a control (CON) group (no intervention). We measured changes in muscle strength, thigh/leg circumferences, and serum growth hormone levels. RESULTS: Immobilization/unloading resulted in significant decreases in muscle strength of knee extensor and flexor muscles (P < 0.01 and < 0.05, respectively) and thigh and leg circumferences (P < 0.05, each) in the CON group, and significant decreases in muscle strength of the knee flexor muscles, ankle plantar flexor muscles, and leg circumference (P < 0.05) in the IMT group. RBF protected against these changes in muscle strength and thigh/leg circumference (P < 0.01 and < 0.05, respectively). No changes in serum growth hormone levels were noted. CONCLUSION: Our results indicate that repetitive restriction of blood flow to the lower extremity prevents disuse muscular weakness. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/18379217/Prevention_of_disuse_muscular_weakness_by_restriction_of_blood_flow_ L2 - https://doi.org/10.1249/MSS.0b013e31815ddac6 DB - PRIME DP - Unbound Medicine ER -