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Traffic-related air pollution and childhood respiratory symptoms, function and allergies.
Epidemiology. 2008 May; 19(3):401-8.E

Abstract

BACKGROUND

Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization.

METHODS

The spatial distribution of nitrogen oxides from traffic (traffic-NOx) and inhalable particulate matter from traffic (traffic-PM10) in the study area was assessed with emission databases and dispersion modeling. Estimated levels were used to assign first-year exposure levels for children in a prospective birth cohort (n = 4089), by linking to geocoded home addresses. Parents in 4 Swedish municipalities provided questionnaire data on symptoms and exposures when the children were 2 months and 1, 2, and 4-year-old. At 4 years, 73% of the children underwent clinical examination including peak expiratory flow and specific IgE measurements.

RESULTS

Exposure to air pollution from traffic during the first year of life was associated with an excess risk of persistent wheezing (odds ratio [OR] for 44 microg/m3 [5th-95th percentile] difference in traffic-NOx = 1.60; 95% confidence interval [CI] = 1.09-2.36). Similar results were found for sensitization (measured as specific IgE) to inhalant allergens, especially pollen (OR for traffic-NOx = 1.67; 95% CI = 1.10-2.53), at the age of 4 years. Traffic-related air pollution exposure during the first year of life was also associated with lower lung function at 4 years of age. Results were similar using traffic-NOx and traffic-PM10 as indicators.

CONCLUSIONS

Exposure to moderate levels of locally emitted air pollution from traffic early in life appears to influence the development of airway disease and sensitization in preschool children.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Nordling E
Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden.
Berglind N
No affiliation info available
Melén E
No affiliation info available
Emenius G
No affiliation info available
Hallberg J
No affiliation info available
Nyberg F
No affiliation info available
Pershagen G
No affiliation info available
Svartengren M
No affiliation info available
Wickman M
No affiliation info available
Bellander T
No affiliation info available

MeSH

Child, PreschoolEnvironmental ExposureFemaleHumansHypersensitivityImmunoglobulin EInfantMaleNitrogen OxidesParticulate MatterProspective StudiesRegression AnalysisRespiratory Function TestsRespiratory Tract DiseasesRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesSwedenVehicle Emissions

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18379426

Citation

Nordling, Emma, et al. "Traffic-related Air Pollution and Childhood Respiratory Symptoms, Function and Allergies." Epidemiology (Cambridge, Mass.), vol. 19, no. 3, 2008, pp. 401-8.
Nordling E, Berglind N, Melén E, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology. 2008;19(3):401-8.
Nordling, E., Berglind, N., Melén, E., Emenius, G., Hallberg, J., Nyberg, F., Pershagen, G., Svartengren, M., Wickman, M., & Bellander, T. (2008). Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology (Cambridge, Mass.), 19(3), 401-8. https://doi.org/10.1097/EDE.0b013e31816a1ce3
Nordling E, et al. Traffic-related Air Pollution and Childhood Respiratory Symptoms, Function and Allergies. Epidemiology. 2008;19(3):401-8. PubMed PMID: 18379426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traffic-related air pollution and childhood respiratory symptoms, function and allergies. AU - Nordling,Emma, AU - Berglind,Niklas, AU - Melén,Erik, AU - Emenius,Gunnel, AU - Hallberg,Jenny, AU - Nyberg,Fredrik, AU - Pershagen,Göran, AU - Svartengren,Magnus, AU - Wickman,Magnus, AU - Bellander,Tom, PY - 2008/4/2/pubmed PY - 2008/8/1/medline PY - 2008/4/2/entrez SP - 401 EP - 8 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 19 IS - 3 N2 - BACKGROUND: Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization. METHODS: The spatial distribution of nitrogen oxides from traffic (traffic-NOx) and inhalable particulate matter from traffic (traffic-PM10) in the study area was assessed with emission databases and dispersion modeling. Estimated levels were used to assign first-year exposure levels for children in a prospective birth cohort (n = 4089), by linking to geocoded home addresses. Parents in 4 Swedish municipalities provided questionnaire data on symptoms and exposures when the children were 2 months and 1, 2, and 4-year-old. At 4 years, 73% of the children underwent clinical examination including peak expiratory flow and specific IgE measurements. RESULTS: Exposure to air pollution from traffic during the first year of life was associated with an excess risk of persistent wheezing (odds ratio [OR] for 44 microg/m3 [5th-95th percentile] difference in traffic-NOx = 1.60; 95% confidence interval [CI] = 1.09-2.36). Similar results were found for sensitization (measured as specific IgE) to inhalant allergens, especially pollen (OR for traffic-NOx = 1.67; 95% CI = 1.10-2.53), at the age of 4 years. Traffic-related air pollution exposure during the first year of life was also associated with lower lung function at 4 years of age. Results were similar using traffic-NOx and traffic-PM10 as indicators. CONCLUSIONS: Exposure to moderate levels of locally emitted air pollution from traffic early in life appears to influence the development of airway disease and sensitization in preschool children. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/18379426/Traffic_related_air_pollution_and_childhood_respiratory_symptoms_function_and_allergies_ DB - PRIME DP - Unbound Medicine ER -