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Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man.
Neurol Sci. 2008 Feb; 29(1):45-6.NS

Abstract

We present the case of a non-alcoholic man, who, following severe malnutrition, presented with dysphagia that necessitated gastrostomy tube placement. The patient subsequently developed encephalopathy, at which point thiamine deficiency was suspected and thiamine supplementation initiated. The encephalopathy and the dysphagia resolved, but the patient was left with a dense amnestic deficit consistent with Korsakoff syndrome. MRI at the time of the encephalopathy revealed lesions consistent with Wernicke-Korsakoff syndrome. This case represents a remarkable example of Wernicke-Korsakoff syndrome that for a prolonged time period had as its sole manifestation severe dysphagia. To our knowledge, there is only one similar case reported in the literature. This case serves to alert neurologists that isolated dysphagia may be the presenting symptom of this classic neurological syndrome even in the absence of alcoholism.

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Authors+Show Affiliations

Karaiskos I
Fourth Department of Internal Medicine, University of Athens Medical School Hospital Attikon, Attiki, Greece.
Katsarolis I
No affiliation info available
Stefanis L
No affiliation info available

MeSH

AdultBrainDeglutition DisordersDiagnosis, DifferentialHumansInfectionsKorsakoff SyndromeMagnetic Resonance ImagingMalePericardial EffusionPleural EffusionThiamine Deficiency

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18379741

Citation

Karaiskos, Ilias, et al. "Severe Dysphagia as the Presenting Symptom of Wernicke-Korsakoff Syndrome in a Non-alcoholic Man." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 29, no. 1, 2008, pp. 45-6.
Karaiskos I, Katsarolis I, Stefanis L. Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. Neurol Sci. 2008;29(1):45-6.
Karaiskos, I., Katsarolis, I., & Stefanis, L. (2008). Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 29(1), 45-6. https://doi.org/10.1007/s10072-008-0859-8
Karaiskos I, Katsarolis I, Stefanis L. Severe Dysphagia as the Presenting Symptom of Wernicke-Korsakoff Syndrome in a Non-alcoholic Man. Neurol Sci. 2008;29(1):45-6. PubMed PMID: 18379741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man. AU - Karaiskos,Ilias, AU - Katsarolis,Ioannis, AU - Stefanis,Leonidas, Y1 - 2008/04/01/ PY - 2007/10/20/received PY - 2008/01/18/accepted PY - 2008/4/2/pubmed PY - 2008/6/5/medline PY - 2008/4/2/entrez SP - 45 EP - 6 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 29 IS - 1 N2 - We present the case of a non-alcoholic man, who, following severe malnutrition, presented with dysphagia that necessitated gastrostomy tube placement. The patient subsequently developed encephalopathy, at which point thiamine deficiency was suspected and thiamine supplementation initiated. The encephalopathy and the dysphagia resolved, but the patient was left with a dense amnestic deficit consistent with Korsakoff syndrome. MRI at the time of the encephalopathy revealed lesions consistent with Wernicke-Korsakoff syndrome. This case represents a remarkable example of Wernicke-Korsakoff syndrome that for a prolonged time period had as its sole manifestation severe dysphagia. To our knowledge, there is only one similar case reported in the literature. This case serves to alert neurologists that isolated dysphagia may be the presenting symptom of this classic neurological syndrome even in the absence of alcoholism. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/18379741/Severe_dysphagia_as_the_presenting_symptom_of_Wernicke_Korsakoff_syndrome_in_a_non_alcoholic_man_ L2 - https://dx.doi.org/10.1007/s10072-008-0859-8 DB - PRIME DP - Unbound Medicine ER -