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Oral controlled release formulations of rifampicin. Part II: Effect of formulation variables and process parameters on in vitro release.
Drug Deliv. 2008 Mar-Apr; 15(3):159-68.DD

Abstract

Hydrophilic controlled release matrix tablets of rifampicin, a poorly soluble drug, have been formulated using hydroxypropyl methylcellulose (HPMC) polymer (low, medium, and high viscosity) by direct compression method. Influence of formulation variables and process parameters such as drug:HPMC ratio, viscosity grade of HPMC, drug particle size, and compression force on the formulation characters and drug release has been studied. Our results indicated that the release rate of the drug and the mechanism of release from the HPMC matrices are mainly controlled by the drug:HPMC ratio and viscosity grade of the HPMC. In general, decrease in the drug particle size decreased the drug release. Lower viscosity HPMC polymer was found to be more sensitive to the effect of compression force than the higher viscosity. The formulations were found to be stable and reproducible.

Authors+Show Affiliations

College of Pharmacy, Western University of Health Sciences, Pomona, California 91766, USA. phiremath@westernu.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18379928

Citation

Hiremath, P S., and R N. Saha. "Oral Controlled Release Formulations of Rifampicin. Part II: Effect of Formulation Variables and Process Parameters On in Vitro Release." Drug Delivery, vol. 15, no. 3, 2008, pp. 159-68.
Hiremath PS, Saha RN. Oral controlled release formulations of rifampicin. Part II: Effect of formulation variables and process parameters on in vitro release. Drug Deliv. 2008;15(3):159-68.
Hiremath, P. S., & Saha, R. N. (2008). Oral controlled release formulations of rifampicin. Part II: Effect of formulation variables and process parameters on in vitro release. Drug Delivery, 15(3), 159-68. https://doi.org/10.1080/10717540801952498
Hiremath PS, Saha RN. Oral Controlled Release Formulations of Rifampicin. Part II: Effect of Formulation Variables and Process Parameters On in Vitro Release. Drug Deliv. 2008 Mar-Apr;15(3):159-68. PubMed PMID: 18379928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral controlled release formulations of rifampicin. Part II: Effect of formulation variables and process parameters on in vitro release. AU - Hiremath,P S, AU - Saha,R N, PY - 2008/4/2/pubmed PY - 2008/6/7/medline PY - 2008/4/2/entrez SP - 159 EP - 68 JF - Drug delivery JO - Drug Deliv VL - 15 IS - 3 N2 - Hydrophilic controlled release matrix tablets of rifampicin, a poorly soluble drug, have been formulated using hydroxypropyl methylcellulose (HPMC) polymer (low, medium, and high viscosity) by direct compression method. Influence of formulation variables and process parameters such as drug:HPMC ratio, viscosity grade of HPMC, drug particle size, and compression force on the formulation characters and drug release has been studied. Our results indicated that the release rate of the drug and the mechanism of release from the HPMC matrices are mainly controlled by the drug:HPMC ratio and viscosity grade of the HPMC. In general, decrease in the drug particle size decreased the drug release. Lower viscosity HPMC polymer was found to be more sensitive to the effect of compression force than the higher viscosity. The formulations were found to be stable and reproducible. SN - 1071-7544 UR - https://www.unboundmedicine.com/medline/citation/18379928/Oral_controlled_release_formulations_of_rifampicin__Part_II:_Effect_of_formulation_variables_and_process_parameters_on_in_vitro_release_ L2 - https://www.tandfonline.com/doi/full/10.1080/10717540801952498 DB - PRIME DP - Unbound Medicine ER -